Effects of Salivary Oxidative Markers on Edentulous Patients’ Satisfaction with Prosthetic Denture Treatments: A Pilot Study

Chang, Chia Huang; Lee, Chang-Yu; Feng, Sheng-Wei; Miao, Nae‐Fang; Lin, Pei Huan; Lin, Chin-Ta; Tsai, Shin-Han; Huang, Yung-Kai

doi:10.1371/journal.pone.0151605

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…In this study, the mean pH was similar to a study carried out in Mexico, where the elderly, fully edentulous and with dentures had an average pH of 7.7 (37). Similar values were also reported in China, where the mean pH of patients with prosthesis was 7.2 (38). The mean buffer capacity of this study was considered regular, but higher than the average buffer capacity reported by Islas-Granillo et al of 4.2.…”

Section: Discussionsupporting

confidence: 85%

Analysis of risk factors for maxillary denture-related oral mucosal lesions: A cross-sectional study

Brantes¹,

Azevedo²,

Rozza-De-Menezes³

et al. 2019

Med Oral

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Background To evaluate the frequency of maxillary dentures-related lesions and the possible associated risk factors. Material and Methods Ninety-seven participants were selected, and a complete anamnesis, physical examination and tests of occlusion vertical dimension (OVD), retention and stability of the denture, biofilm quantification, cytopathology, sialometry, pH analysis and buffer capacity of the saliva were performed. Statistical analyses were performed with the Pearson’s chi-square, Mann-Whitney tests, and Pearson’s coefficient ( p <0.05). Results In 78% of the participants at least one denture-related lesion was found. Denture-associated stomatitis (63%), inflammatory fibrous hyperplasia (19%) and traumatic ulceration (11%) were the 3 most frequent lesions. The habit of night use of the denture was considered an independent risk factor for the development of oral lesions [OR=3.0 (95% CI 1.09-8.56); p <0.05]. Furthermore, the longest period of use of the same denture and biofilm also had statistically significant relation to oral lesions. The biofilm seems to be more related to the prevalence of oral lesions according to the multiple logistic regression [OR=1.3 (95% CI: 1.01-1.83) p <0.05]. The lack of a dentures’ cleaning solution and detrition of the prothesis were independent risk factors for denture-associated stomatitis. Male gender, loss of OVD and bad buffer capacity were risk factors for angular cheilitis. Fractures of the base and repair of broken dentures were risk factors for traumatic ulcers. Conclusions These results show a high frequency of denture-related lesions. Besides, participants hygiene habits and poor quality of the dentures were the main factors for the development of these lesions. Key words: Complete denture, oral health, oral hygiene, oral lesion, saliva.

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Section: Discussionsupporting

confidence: 85%

Analysis of risk factors for maxillary denture-related oral mucosal lesions: A cross-sectional study

Brantes¹,

Azevedo²,

Rozza-De-Menezes³

et al. 2019

Med Oral

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“…Previous studies showed that the gingival index was significantly associated with salivary SOD, and salivary SOD also significantly decreased in patients after periodontal disease treatment [26]. Our previous study also showed that SOD significantly increased with an increment in the BOP [38]. Endogenous antioxidants are associated with periodontitis as shown in this study.…”

Section: Discussionsupporting

confidence: 79%

A Cross-Sectional Study of Endogenous Antioxidants and Patterns of Dental Visits of Periodontitis Patients

Lee

Choy

Lai

et al. 2019

IJERPH

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Periodontitis is an inflammatory disease, wherein endogenous antioxidants help to balance the inflammatory status. Oral health behaviors are related to the periodontal disease status. The aim of this study was to explore the associations between oral health behaviors and endogenous antioxidants in periodontitis patients. In total, 225 subjects diagnosed with periodontitis were enrolled in the study. Information obtained from the initial interview included socioeconomic and demographic characteristics, lifestyle factors, and oral health-related behaviors. The clinical periodontal parameters evaluated included bleeding on probing (BOP), the plaque index (PI), and probing depth (PD). Stimulated saliva was collected before periodontal therapy to determine five endogenous antioxidants (copper-zinc superoxide dismutase (Cu/Zn SOD), manganese SOD (MnSOD), thioredoxin 1 (Trx1), peroxiredoxin 2 (Prx2), and catalase (CAT)). When these five factors were adjusted for in patients whose last previous dental visit was >1 year, the patients’ PI, BOP, and PD showed significant decreases because of an elevation in the Cu/Zn SOD level. Associations of endogenous antioxidants with levels of clinical periodontal parameters were much higher in subjects whose last previous dental visit was >1 year, compared to subjects whose last previous dental visit was <1 year. This study provides a better understanding of dental visit patterns and the salivary endogenous antioxidants that may underlie the symptomatic development of preclinical periodontitis.

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“…Denture treatment is not only effective for aesthetic and functional recovery, such as mastication, but also affects the patient’s general condition as the use of dentures improves the nutritional intake efficiency and thereby the patient’s nutritional status [ 15 ]. Patients’ satisfaction with prosthetic denture treatment are reportedly related to antioxidants and oxidizing enzymes in saliva [ 16 ]. However, ill-fitting dentures not only result in mucosal lesions in the oral cavity, they also lead to oral discomfort symptoms, nutritional intake, and social communication problems [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Denture Treatment on Salivary Metabolites: A Pilot Study

Ichigaya,

Kawanishi,

Adachi

et al. 2023

IJMS

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Symptoms of oral discomfort such as dry mouth are common in older people wearing dentures. Such symptoms are mainly treated symptomatically. Many of these symptoms are related to saliva, and associations with salivary volume have been reported. Although denture treatment improves symptoms by increasing the amount of saliva, the effects on salivary components remain unclear. This study aimed to investigate the effects of denture treatment on salivary metabolite changes based on salivary metabolome analyses. We enrolled 21 patients requiring denture treatment. At the first visit, and after completion of denture treatment, saliva outflow was measured under resting and stimulated conditions, samples for salivary metabolite analysis were collected, and masticatory efficiency was tested. In all participants, masticatory efficiency increased after denture treatment. Moreover, the amounts of resting and stimulated saliva were increased. Using salivary metabolome analysis, 61 salivary metabolites were detected. Substantial concentration changes were observed for 4 and 21 metabolites in resting and stimulated saliva, respectively. The four metabolites common to both saliva tests had significantly lower concentrations after treatment. These results suggest that the improvement in masticatory function by dentures is related not only to salivary secretion volume, but also to salivary metabolite composition.

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Effects of Salivary Oxidative Markers on Edentulous Patients’ Satisfaction with Prosthetic Denture Treatments: A Pilot Study

Cited by 4 publications

References 44 publications

Analysis of risk factors for maxillary denture-related oral mucosal lesions: A cross-sectional study

Analysis of risk factors for maxillary denture-related oral mucosal lesions: A cross-sectional study

A Cross-Sectional Study of Endogenous Antioxidants and Patterns of Dental Visits of Periodontitis Patients

Effects of Denture Treatment on Salivary Metabolites: A Pilot Study

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