A Cross-Sectional Study of Endogenous Antioxidants and Patterns of Dental Visits of Periodontitis Patients

Lee, Chang Yu; Choy, Cheuk Sing; Lai, Yinchieh; Chang, Chao; Teng, Nai Chia; Huang, Wan Ting; Lin, Che Tong; Huang, Yung Kai

doi:10.3390/ijerph16020180

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…In the final qualification, 4 stu dies with endpoints different from the adopted ones were excluded. [19][20][21][22] Finally, 11 controlled clinical studies were classified for the overview, [23][24][25][26][27][28][29][30][31][32][33] along with 4 clinical in tervention studies. [34][35][36][37] The process of selecting works for the systematic review is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature

Toczewska¹,

Konopka²

2019

Dent. Med. Probl.

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Periodontitis is initiated by a bacterial infection and an abnormal immune response of the host resulting in the formation of dysbiotic subgingival biofilm and the progressive destruction of the attachment apparatus of the teeth. It is believed that disturbances in the local and/or general indicators of oxidative stress are one of the mechanisms in the etiopathogenesis of periodontitis. Organisms using oxygen in their metabolic processes are equipped with mechanisms that protect against the activity of oxygen-free radicals. They are commonly referred to as 'the antioxidative barrier of the system' . The main enzymatic antioxidants which have been widely studied in the gingival fluid, saliva and blood serum of patients with periodontitis are superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT).The aim of this systematic overview of the literature was to present the current research on the activity of these antioxidant enzymes in the gingival fluid, saliva and blood serum of patients with periodontitis.Findings on the activity of these enzymes in the gingival tissue, gingival fluid, saliva, and blood serum in the course of the types of periodontitis that have been classified so far (chronic or aggressive) are quite disparate. Their activity in the gingival tissue was usually elevated, whereas in the saliva it was reduced. These differences may have resulted from the different methods of biochemically assessing their activity, and may have not reflected the stage and/or the risk of progression of periodontitis.

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Section: Resultsmentioning

confidence: 99%

Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature

Toczewska¹,

Konopka²

2019

Dent. Med. Probl.

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“…On the one hand, under oxidative stress, excess ROS could overwhelm endogenous antioxidants (T-SOD, CAT, GPX1, etc. ), leading to irreversible accumulation in cells [24,25], thus…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, under oxidative stress, excess ROS could overwhelm endogenous antioxidants (T-SOD, CAT, GPX1, etc. ), leading to irreversible accumulation in cells [24,25], thus damaging the mitochondrial structure, collapsing the mitochondrial membrane potential, and initiating key apoptotic events. In this research, the generation of ROS was enhanced by UVB stimulation.…”

Section: Discussionmentioning

confidence: 99%

Heptapeptide Isolated from Isochrysis zhanjiangensis Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

Zheng

Xiao

et al. 2021

Marine Drugs

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Marine microalgae can be used as sustainable protein sources in many fields with positive effects on human and animal health. DAPTMGY is a heptapeptide isolated from Isochrysis zhanjiangensis which is a microalga. In this study, we evaluated its anti-photoaging properties and mechanism of action in human immortalized keratinocytes cells (HaCaT). The results showed that DAPTMGY scavenged reactive oxygen species (ROS) and increase the level of endogenous antioxidants. In addition, through the exploration of its mechanism, it was determined that DAPIMGY exerted anti-photoaging effects. Specifically, the heptapeptide inhibits UVB-induced apoptosis through down-regulation of p53, caspase-8, caspase-3 and Bax and up-regulation of Bcl-2. Thus, DAPTMGY, isolated from I. zhanjiangensis, exhibits protective effects against UVB-induced damage.

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“…Furthermore, alterations of cytokine network may play important roles in the link between PD and SS. Alterations of the cytokine profile in serum or saliva have been reported in patients with PD, including IL-1, IL-6, IL-10, IL-17A, IL-17F, IL-22, IL-25, IL-33, tumor necrosis factor-alpha and interferon-gamma [ 17 , 18 , 35 , 36 , 37 ]. An increased risk of systemic diseases, such as cardiovascular diseases, diabetes, rheumatoid arthritis, preeclampsia, preterm birth and ulcerative colitis, has been reported in previous studies [ 14 , 20 , 21 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Periodontal Disease and Subsequent Sjögren’s Syndrome: A Nationwide Population-Based Cohort Study

Lin

Tseng

Liu

et al. 2019

IJERPH

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Xerostomia (dry mouth) is the cardinal symptom of Sjögren’s syndrome (SS), which is an autoimmune disease involving the exocrine glands and other organs. Xerostomia may predispose patients to periodontal disease (PD) and an association between SS and PD has been reported. This association may be bidirectional; therefore, we conducted this study to investigate the risk of SS in patients with PD using data from the National Health Insurance Research Database of Taiwan. A total of 135,190 patients were enrolled in our analysis. In all, 27,041 patients with PD were matched by gender, age, insured region, urbanization and income, with cases and controls in a 1:4 ratio. Both groups were followed and the risks of SS were calculated by Cox proportional hazards regression. Finally, 3292 (2.4%) patients had newly diagnosed SS. Patients with PD had a significantly higher risk of subsequent SS (903 (3.3%) vs. 2389 (2.2%), adjusted hazard 1.47, 95% confidence interval: 1.36–1.59). In conclusion, patients with PD had an approximately 50% increased risk of subsequent SS. Physicians should be aware of the symptoms and signs of SS in patients with PD.

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A Cross-Sectional Study of Endogenous Antioxidants and Patterns of Dental Visits of Periodontitis Patients

Cited by 8 publications

References 45 publications

Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature

Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature

Heptapeptide Isolated from Isochrysis zhanjiangensis Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

Association between Periodontal Disease and Subsequent Sjögren’s Syndrome: A Nationwide Population-Based Cohort Study

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