Effects of resveratrol on growth and skeletal muscle physiology of juvenile southern flounder

Wilson, Whitney N.; Baumgarner, Bradley L.; Watanabe, Wade O.; Alam, Shah; Kinsey, Stephen T.

doi:10.1016/j.cbpa.2014.12.014

Cited by 39 publications

(17 citation statements)

References 62 publications

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“…In this study, we demonstrate a positive modulatory effect on muscle development and growth of curcumin and grape seed extracts, when added as dietary supplements in sole postlarvae. This growth-promoting effect of curcumin and grape seed is in accordance with previous studies in other fish species (Cui et al, 2013;Wilson et al, 2015;Jiang et al, 2016;Akdemir et al, 2017; Mahmoud et al, 2017;Kesbiç and Yigit, 2019). Both CC and GS diets significantly improved the DW and SL in relation to the CTRL fish.…”

Section: Discussionsupporting

confidence: 91%

Dietary Antioxidant Supplementation Promotes Growth in Senegalese Sole Postlarvae

et al. 2020

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Somatic growth is a balance between protein synthesis and degradation, and it is largely influenced by nutritional clues. Antioxidants levels play a key role in protein turnover by reducing the oxidative damage in the skeletal muscle, and hence promoting growth performance in the long-term. In the present study, Senegalese sole postlarvae (45 days after hatching, DAH) were fed with three experimental diets, a control (CTRL) and two supplemented with natural antioxidants: curcumin (CC) and grape seed (GS). Trial spanned for 25 days and growth performance, muscle cellularity and the expression of muscle growth related genes were assessed at the end of the experiment (70 DAH). The diets CC and GS significantly improved growth performance of fish compared to the CTRL diet. This enhanced growth was associated with larger muscle cross sectional area, with fish fed CC being significantly different from those fed the CTRL. Sole fed the CC diet had the highest number of muscle fibers, indicating that this diet promoted muscle hyperplastic growth. Although the mean fiber diameter did not differ significantly amongst treatments, the proportion of large-sized fibers (>25 μm) was also higher in fish fed the CC diet suggesting increased hypertrophic growth. Such differences in the phenotype were associated with a significant up-regulation of the myogenic differentiation 2 ( myod2 ) and the myomaker ( mymk ) transcripts involved in myocyte differentiation and fusion, respectively, during larval development. The inclusion of grape seed extract (GS diet) resulted in a significant increase in the expression of myostatin1 . These results demonstrate that both diets (CC and GS) can positively modulate muscle development and promote growth in sole postlarvae. This effect is more prominent in CC fed fish, where increased hyperplastic and hypertrophic growth of the muscle was associated with an upregulation of myod2 and mymk genes.

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Section: Discussionsupporting

confidence: 91%

Dietary Antioxidant Supplementation Promotes Growth in Senegalese Sole Postlarvae

et al. 2020

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“…Dietary vitamin E supplementation also showed a dose-dependent mode of action and prevented tissues from lipid oxidation when administered at doses above 100 mg/kg to red sea bream [ 77 ] and salmon [ 78 ]. In this study, RV was administered at doses of 3 g/kg, which represented the upper margin of previously applied concentrations in fish [ 79 , 80 , 81 , 82 ]. The described effects may help to understand the lack of effects on the expression of certain genes (PPARα, CPT1a and CPT1c), but increased protein abundance of ∆6-D and elevated PUFA contents.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Profile Is Modulated by Dietary Resveratrol in Rainbow Trout (Oncorhynchus mykiss)

et al. 2017

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To produce fish of a high quality that are rich in omega-3 fatty acids (n-3 FA) and simultaneously generate more sustainable aquaculture, the combined use of phytochemicals and vegetable oils in fish feed seems to be a promising approach. Resveratrol (RV) potentially induces endogenous fatty acid synthesis, resulting in elevated n-3 FA levels in fish. RV putatively influences ∆6-desaturase, the key enzyme in FA metabolism, and serves as a ligand for PPARα, a transcription factor regulating β-oxidation. Rainbow trout (36.35 ± 0.03 g) were randomly allocated into six groups and fed diets with reduced fish oil levels (F4 = 4%, F2 = 2% and F0 = 0% of dry matter) supplemented with 0.3% (w/w) RV (F4 + RV, F2 + RV and F0 + RV). RV significantly affected FA composition in liver tissue and whole fish homogenates. 20:5n-3 (EPA) and 22:6n-3 (DHA) were significantly increased whereas precursor FA were diminished in fish fed the F2 + RV and F0 + RV diets when compared to F4 + RV and F0. RV significantly elevated ∆6-desaturase protein levels in the livers of F0 + RV fed animals. Hepatic mRNA expression of ∆6-desaturase, PPARα, and its target genes were affected by the dietary fish oil level and not by dietary RV. The results of this study indicated a potential benefit of supplementing RV in fish oil deprived diets elevating n-3 FA levels in rainbow trout.

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“…Interestingly, resveratrol drastically impacted the muscle fiber characteristics and antioxidative capacity of finished pigs, suggesting that resveratrol is an effective additive to improve pork meat quality (99). Likewise, juvenile Southern flounders that were fed a diet supplemented with 600 mg resveratrol/g of food for 16 wk showed a greater length and body mass than fish fed a control diet (100). Such studies indicate that resveratrol is a new supplement to enhance growth in different agricultural and aquacultural settings.…”

Section: Resveratrol and Musclementioning

confidence: 93%

Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?

Weiskirchen

2016

Advances in Nutrition

246

168

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Resveratrol is a naturally occurring stilbene endowed with multiple health-promoting effects. It is produced by certain plants including several dietary sources such as grapes, apples, raspberries, blueberries, plums, peanuts, and products derived therefrom (e.g., wine). Resveratrol can be isolated and purified from these biological sources or synthesized in a few steps with an overall high yield. This compound and its glucoside, the trans-polydatin piceid, have received worldwide attention for their beneficial effects on cardiovascular, inflammatory, neurodegenerative, metabolic, and age-related diseases. These health-promoting effects are particularly attractive given the prevalence of resveratrol-based nutraceuticals and the paradoxical epidemiologic observation that wine consumption is inversely correlated to the incidence of coronary heart disease. However, the notion of resveratrol as a "magic bullet" was recently challenged by clinical trials showing that this polyphenol does not have a substantial influence on health status and mortality risk. In the present review, we discuss the proposed therapeutic attributes and the mode of molecular actions of resveratrol. We also cover recent pharmacologic efforts to improve the poor bioavailability of resveratrol and influence the transition between body systems in humans. We conclude with some thoughts about future research directions that might be meaningful for resolving controversies surrounding resveratrol.

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Effects of resveratrol on growth and skeletal muscle physiology of juvenile southern flounder

Cited by 39 publications

References 62 publications

Dietary Antioxidant Supplementation Promotes Growth in Senegalese Sole Postlarvae

Dietary Antioxidant Supplementation Promotes Growth in Senegalese Sole Postlarvae

Fatty Acid Profile Is Modulated by Dietary Resveratrol in Rainbow Trout (Oncorhynchus mykiss)

Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?

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