Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcome

Jahanfar, Shayesteh; Jaafar, Sharifah Halimah

doi:10.1002/14651858.cd006965.pub2

Cited by 14 publications

(8 citation statements)

References 29 publications

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“…• were narrative/systematic reviews (n = 14) • were meta-analyses on the effects of a number of exposures, including but not limited to coffee (n = 6) • were meta-analyses of a selected group of cohorts (n = 2) • was a meta-analysis of nonrandomized/ noncontrolled trial (n =1) Flowchart of studies selected for inclusion in the umbrella review of coffee, caffeine, and health outcomes. (47,88,97,130,155). A total of 59 outcomes related to coffee exposure and 14 related to caffeine were examined in observational studies, and 6 outcomes related to coffee and 9 related to caffeine were examined in RCTs (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Coffee, Caffeine, and Health Outcomes: An Umbrella Review

2017

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To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet.

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Section: Resultsmentioning

confidence: 99%

Coffee, Caffeine, and Health Outcomes: An Umbrella Review

2017

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“…The effect of caffeine intake has been evaluated for its pregnancy and fetal effects in multiple studies. [61][62][63] As it pertains to SIDS, Ford and Nelson 38 (n ¼ 393) found an increased risk of SIDS among women with high intrapartum intake of caffeine, an association disputed by Alm et al, 59 who published a series of 244 cases that showed no association. The actual mechanism that underlines any effect on the occurrence of SIDS is uncertain and is likely associated through possible links to high-risk behaviors such as heavy smoking.…”

Section: Caffeine Intakementioning

confidence: 99%

Sudden Infant Death Syndrome: Review for the Obstetric Care Provider

Nguyen

Abenhaim

2013

Amer J Perinatol

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Sudden infant death syndrome (SIDS) is the leading cause of death among infants aged 1 to 12 months. In this article, we review risk factors that may predispose infants to increased vulnerability. Maternal characteristics, including nonmodifiable and modifiable factors, antenatal medical conditions, labor and delivery events, and infant characteristics, are reviewed, with the purpose of helping obstetric care providers target risk reduction efforts. We have reviewed over 85 case-control, retrospective, and prospective cohort studies published between 1975 and 2011. Major modifiable risk factors include maternal and paternal smoking, drug use, alcohol use, and insufficient prenatal care. Infants at increased risk include males, premature infants, infants of low birth weight or growth-restricted infants, and infants in multiple gestations. By targeting modifiable and nonmodifiable risk factors, it may be possible to decrease the incidence of SIDS. Efforts should be put on decreasing high-risk behaviors and encouraging sufficient antenatal follow-up. In view of recent increases in ethnic and social disparity with SIDS, it is essential that risk reduction guidelines, which have recently been expanded by the American Association of Pediatrics, be explained in a culturally sensitive manner.

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“…However, so far, only inconclusive results were found. In its periodic meta-analyzes updates of randomized controlled trials in humans, Jahanfar and Jaafar [13,70,71] stated that there are insufficient evidences to support alterations in the maximum caffeine recommendation intake by mother on general pregnancy disorders. Greenwood and cols [48] concluded in their meta-analysis in a similar way as Jahanfar and Jaafar.…”

Section: Caffeine Intake During Pregnancy: What Are the Real Evidences?mentioning

confidence: 99%

Caffeine Intake during Pregnancy: What Are the Real Evidences?

Paula¹,

Shang²,

Chiarini‐Garcia³

et al. 2017

JPP

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Abstract:Caffeine is a substance presented in foods such as coffee, tea, soft drinks, chocolates and medicines and is commonly consumed by pregnant women. Due to its ability to cross the placental membrane and accumulate in the fetus body, caffeine and its metabolites have been contraindicated or recommended in small doses during pregnancy. Studies in rodents relate caffeine intake to lower rates of fertilization, embryonic implantation, changes in placental structure, increased occurrence of low fetal and placental weights, abortion and stillbirth. However, in humans, studies involving caffeine consumption are inconclusive. Methodological complexity, difficulty for measuring caffeine intake and ethical reasons are limiting factors for a more accurate conclusion. So far, caffeine recommendation ranges from 100 to 300 mg/day. Even though researches have recommended low caffeine consumption by pregnant women in order to avoid deleterious consequences during gestation, a safe dose has not been established until now. The aim of the present review is to describe the main findings on the effects of caffeine consumption during pregnancy in both human and rodent experimental models.

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Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcome

Abstract: There is insufficient evidence to confirm or refute the effectiveness of caffeine avoidance on birthweight or other pregnancy outcomes. There is a need to conduct high-quality, double-blinded RCTs to determine whether caffeine has any effect on pregnancy outcome.

Cited by 14 publications

References 29 publications

Coffee, Caffeine, and Health Outcomes: An Umbrella Review

Coffee, Caffeine, and Health Outcomes: An Umbrella Review

Sudden Infant Death Syndrome: Review for the Obstetric Care Provider

Caffeine Intake during Pregnancy: What Are the Real Evidences?

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