Caffeine Intake during Pregnancy: What Are the Real Evidences?

Abstract

Abstract:Caffeine is a substance presented in foods such as coffee, tea, soft drinks, chocolates and medicines and is commonly consumed by pregnant women. Due to its ability to cross the placental membrane and accumulate in the fetus body, caffeine and its metabolites have been contraindicated or recommended in small doses during pregnancy. Studies in rodents relate caffeine intake to lower rates of fertilization, embryonic implantation, changes in placental structure, increased occurrence of low fetal and placental weights, abortion and stillbirth. However, in humans, studies involving caffeine consumption are inconclusive. Methodological complexity, difficulty for measuring caffeine intake and ethical reasons are limiting factors for a more accurate conclusion. So far, caffeine recommendation ranges from 100 to 300 mg/day. Even though researches have recommended low caffeine consumption by pregnant women in order to avoid deleterious consequences during gestation, a safe dose has not been established until now. The aim of the present review is to describe the main findings on the effects of caffeine consumption during pregnancy in both human and rodent experimental models.

Effect of Garbhini Ahara-Vihara (Diet & Lifestyle in Pregnancy) On Garbhastha Sishu (Fetus) and Offspring

“…(4) Effect of excessive coffee intake on fetus: -Caffeine is rich source of foods such as coffee, tea, soft drinks, chocolates and its excessive intake increase chance of birth defect on fetus [23] . Caffeine intake is negatively associated with low birth and placental weight, greater number of stillbirths, increased expression of apoptotic markers and altered placental and bone formation [24] .…”