Effects of reserpine on expression of the LDL receptor in liver and on plasma and tissue lipids, low density lipoprotein and fibrinogen in rabbits in vivo

Shafi, Shahida; Stepanova, I. P.; Fitzsimmons, Colin M.; Bowyer, David E.; Welzel, D; Born, G. V. R.

doi:10.1016/s0021-9150(99)00327-5

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…This was contrary to the observations published earlier by Loest [8]. Reserpine is known to increase high affinity LDL receptors in liver [10] thus increasing liver cholesterol.…”

Section: Resultscontrasting

confidence: 99%

CoQ₉ potentiates green tea antioxidant activities in Wistar rats

Afzal¹,

Safer²,

Al-Bloushi³

2005

BioFactors

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Green tea (Camellia sinensis), and CoQ(9 )when given to Wistar rats produced a partial reversal on reserpine induced oxidative stress and liver damage. Green tea, with its abundant polyphenol (-)Epigallocatechin 3-gallate (ECGC) and other catechins, is known for its antioxidative characteristics influencing lipid metabolism. Ubiquinone, abundant in heart muscle, is also a potent antioxidant with known effects in numerous pathologies. However the combined effect of ECGC and ubiquninone has not been reported. In the present study we found that green tea extract, when given in combination with CoQ(9) to Wistar rats subjected to oxidative stress, showed a statistically significant antioxidative effect. Liver cholesterol level in rats receiving combination treatment was also significantly lower than control or rats receiving green tea extract alone. Reserpine induced liver damage in Wistar rats was also partially reversed by a treatment of green tea extract when combined with CoQ(9). These results may have important clinical implications and may be extrapolated for the treatment of patients suffering from liver damage due to hepatitis B/C or liver cirrhosis.

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“…This was contrary to the observations published earlier by Loest [8]. Reserpine is known to increase high affinity LDL receptors in liver [10] thus increasing liver cholesterol.…”

Section: Resultscontrasting

confidence: 99%

CoQ₉ potentiates green tea antioxidant activities in Wistar rats

Afzal¹,

Safer²,

Al-Bloushi³

2005

BioFactors

View full text Add to dashboard Cite

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Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers

Yaghmur,

Østergaard,

2023

Advanced Drug Delivery Reviews

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Effect of Reserpine Treatment on Low-Density Lipoproteins in Arterial Wall and Internal Organs of Rats

Shafi

Welzel²,

Weidinger³

et al. 2000

Journal of Cardiovascular Pharmacology

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The effects were determined in rats of single injections of reserpine at increasing doses (0.5, 1.58, and 5.0 mg/kg) on low-density lipoprotein (LDL) and cholesterol in aortic wall, heart, liver, kidney, and adrenal gland. Catecholamine levels in plasma, heart, and liver, arterial blood pressure, and heart rate were also monitored. Reserpine was injected intraperitoneally, followed immediately by the administration of [3H]cholesterol by gavage. Twelve hours later, homologous 125I-tyramine cellobiose-labeled LDL (125I-TC-LDL) was injected intravenously. Twenty-four hours later, the rats were killed, and the radioactivities of aortic walls, heart, liver, kidney, and adrenal glands were determined. The results showed that after reserpine treatment the accumulation of both the 125I-TC label derived from LDL and total [3H]cholesterol was significantly reduced in aortic wall and heart, increased in liver, and unchanged in the kidney and adrenal gland. At higher doses (1.58 and 5.0 mg/kg), reserpine significantly accelerated the plasma clearance of radiolabelled LDL. Plasma noradrenaline in reserpine-treated animals decreased maximally (86%) by 12 h and by 61-71% at 36 h compared with the control. Plasma adrenaline increased transiently after injection of reserpine and then returned to the basal levels. Reserpine greatly decreased noradrenaline and adrenaline levels in heart and liver. Arterial blood pressure was decreased significantly (0.001 < p < 0.05) at 12 h by the two lower doses of reserpine and then returned to normal values over the next 24 h. The results indicate that reserpine decreases LDL cholesterol in artery wall and heart and increases it in liver. These findings suggest that reserpine could find a new use as a cholesterol-lowering drug for the prevention of atherosclerosis.

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Effects of reserpine on expression of the LDL receptor in liver and on plasma and tissue lipids, low density lipoprotein and fibrinogen in rabbits in vivo

Cited by 5 publications

References 37 publications

CoQ₉ potentiates green tea antioxidant activities in Wistar rats

CoQ₉ potentiates green tea antioxidant activities in Wistar rats

Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers

Effect of Reserpine Treatment on Low-Density Lipoproteins in Arterial Wall and Internal Organs of Rats

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Effects of reserpine on expression of the LDL receptor in liver and on plasma and tissue lipids, low density lipoprotein and fibrinogen in rabbits in vivo

Cited by 5 publications

References 37 publications

CoQ9 potentiates green tea antioxidant activities in Wistar rats

CoQ9 potentiates green tea antioxidant activities in Wistar rats

Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers

Effect of Reserpine Treatment on Low-Density Lipoproteins in Arterial Wall and Internal Organs of Rats

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CoQ₉ potentiates green tea antioxidant activities in Wistar rats

CoQ₉ potentiates green tea antioxidant activities in Wistar rats