Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers

Yaghmur, Anan; Østergaard, Jesper; Mu, Huiling

doi:10.1016/j.addr.2023.115136

Cited by 9 publications

(2 citation statements)

References 127 publications

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“…By modifying their surface properties [ 116 – 118 ], LNPs can be designed to target specific tissues or cell types, thereby improving therapeutic relevance and efficiency. They are mainly used as controlled- and sustained-release drug carriers [ 119 , 120 ], gene therapy [ 121 , 122 ], artificial tissue and organ construction [ 123 ], vaccine development [ 124 ], and anticancer drug delivery [ 125 ], and have the advantages of good biocompatibility and biodegradability, high encapsulation efficiency, long circulation time, nontoxicity or relatively low toxicity, and slow clearance by body immune cells [ 126 , 127 ].…”

Section: Nanoregulator Design For Dynamic Restorationmentioning

confidence: 99%

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Jiang,

Zhang,

et al. 2024

J Nanobiotechnol

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The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovarian tissue cryopreservation and transplantation (OTC-T), including the risk of tissue damage and dysfunction. Consequently, there has been a compelling exploration into the realm of nanoregulators to refine and enhance these procedures. This review embarks on a meticulous examination of the intricate anatomical structure of the ovary and its microenvironment, thereby establishing a robust groundwork for the development of nanomodulators. It systematically categorizes nanoregulators and delves deeply into their functions and mechanisms, meticulously tailored for optimizing ovarian tissue cryopreservation and transplantation. Furthermore, the review imparts valuable insights into the practical applications and obstacles encountered in clinical settings associated with OTC-T. Moreover, the review advocates for the utilization of microbially derived nanomodulators as a potent therapeutic intervention in ovarian tissue cryopreservation. The progression of these approaches holds the promise of seamlessly integrating nanoregulators into OTC-T practices, thereby heralding a new era of expansive applications and auspicious prospects in this pivotal domain. Graphical Abstract

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Section: Nanoregulator Design For Dynamic Restorationmentioning

confidence: 99%

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Jiang,

Zhang,

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“… 16 , 17 This phenomenon is usually caused by biochemical mechanisms within the tumor cells, such as drug efflux, drug catabolism, DNA repair. 18 , 19 , 20 , 21 , 22 , 23 In the field of oncology, NPs have been extensively studied as drug carriers to overcome the problem of drug resistance faced by conventional chemotherapeutic agents. 24 , 25 NPs as drug carriers have the following advantages.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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Gliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

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Dual pH and Ca²⁺‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity

Shao,

Duan,

Huang

et al. 2024

Chemistry A European J

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Chemotherapy is one of the most employed strategies in clinical treatment of cancer. However, reducing medication adverse effects and improving the biological activity remains a significant issue for chemotherapy. We developed a pH and Ca2+‐responsive pillar[5]arene‐based supramolecular nanodrug delivery system (NDDS) WP5⊃EV@DOX to address the aforementioned challenges. The formation of this NDDS began with the spontaneous formation of supramolecular nanodrug carrier WP5⊃EV in water from PEG‐modified pillar[5]arene and the bipyridilium salt derivative EV through simple host‐guest interaction. Then the antitumor drug doxorubicin DOX was efficiently loaded with a high encapsulation rate of 84.6%. Cytotoxicity results indicated that the constructed nanoplatform not only reduced DOX toxicity and side effects on normal cell (293T), but also significantly enhanced the antitumor activity on cancer cell (HepG2). Moreover, in vivo experiments showed that WP5⊃EV@DOX had a longer half‐life and higher bioavailability in the blood of mice compared to the nake drug DOX, with increases to 212% and 179%, respectively. Therefore, WP5⊃EV@DOX has great potential in tumor therapy and provides a new idea for host‐guest drug delivery system.

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Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers

Cited by 9 publications

References 127 publications

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Dual pH and Ca²⁺‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity

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Lipid nanoparticles for targeted delivery of anticancer therapeutics: Recent advances in development of siRNA and lipoprotein-mimicking nanocarriers

Cited by 9 publications

References 127 publications

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Dual pH and Ca2+‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity

Contact Info

Product

Resources

About

Dual pH and Ca²⁺‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity