CoQ₉ potentiates green tea antioxidant activities in Wistar rats

Abstract

Green tea (Camellia sinensis), and CoQ(9 )when given to Wistar rats produced a partial reversal on reserpine induced oxidative stress and liver damage. Green tea, with its abundant polyphenol (-)Epigallocatechin 3-gallate (ECGC) and other catechins, is known for its antioxidative characteristics influencing lipid metabolism. Ubiquinone, abundant in heart muscle, is also a potent antioxidant with known effects in numerous pathologies. However the combined effect of ECGC and ubiquninone has not been reported. In the present study we found that green tea extract, when given in combination with CoQ(9) to Wistar rats subjected to oxidative stress, showed a statistically significant antioxidative effect. Liver cholesterol level in rats receiving combination treatment was also significantly lower than control or rats receiving green tea extract alone. Reserpine induced liver damage in Wistar rats was also partially reversed by a treatment of green tea extract when combined with CoQ(9). These results may have important clinical implications and may be extrapolated for the treatment of patients suffering from liver damage due to hepatitis B/C or liver cirrhosis.

GPCR6A Is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea

“…Green tea ( Camellia sinensis L.) consumption is reported to have multiple health benefits, including reducing the risks for developing metabolic syndrome (MetS), type 2 diabetes (T2D), and prostate cancer (PCa), as well as many others . Gallates represent 50% of the naturally occurring polyphenolic compounds in green tea and are also present in gallnuts, wine, chocolate, fruits, and vegetables …”