Effects of replacing sitting time with physical activity on lung function: An analysis of the Canadian Longitudinal Study on Aging

Dogra, Shilpa; Good, Joshua; Gardiner, Paul A.; Copeland, Jennifer L.; Stickland, Michael K.; Rudoler, David; Buman, Matthew P.

doi:10.25318/82-003-x201900300002-eng

Cited by 15 publications

(13 citation statements)

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“… 22 The previous study showed that replacing sedentary time with other physical activity leads to significant improvements in lung function in COPD patients, suggesting that physicians should pay more attention to the physical activity levels of patients with mild COPD. 37 The time spent watching television is also reportedly longer in patients with COPD as compared to healthy older subjects. 38 Our results suggest that patients might benefit from even low-intensity exercise, such as standing up during television commercials.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Reduction of Sedentary Time Following Tiotropium/Olodaterol Therapy in Treatment-Naïve Chronic Obstructive Pulmonary Disease

Takahashi¹,

Tashiro²,

Tajiri³

et al. 2021

COPD

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Background: Prolonged sedentary behavior is associated with worse prognosis in patients with chronic obstructive pulmonary disease (COPD). Our previous study found that first-line dual therapy with tiotropium/olodaterol significantly reduces sedentary time compared to tiotropium monotherapy in Japanese patients with treatment-naïve COPD, although the characteristics of responders to dual-therapy versus monotherapy for COPD are still unclear. Methods: Patients with treatment-naïve COPD were randomized to receive either tiotropium or tiotropium/olodaterol treatment for 12 weeks. Physical activity was assessed using a triaxle accelerometer for 2 weeks before and after treatment. This analysis focused on the change in sedentary time, indicated by physical activity of 1.0-1.5 metabolic equivalents (METs), with stratification for the following factors: age, body mass index (BMI), pulmonary function, COPD assessment test (CAT), the 6-minute walk distance (6MWD), and physical activity level at study entry. Results: Thirty-five patients received tiotropium/olodaterol and 34 patients received tiotropium. In patients with lower inspiratory capacity at study entry, a significant reduction in sedentary time was observed in the tiotropium/olodaterol group compared with the tiotropium group (Tio: −12.8 ± 13.5 min, Tio/Olo: −65.1 ± 21.0 min, mean difference, −52.2 min, 95% CI −103.6 to 0.88, p = 0.046). In patients with a shorter duration of physical activity of ≥2 METs at study entry, a significant reduction of sedentary time was observed in the tiotropium/olodaterol group compared with the tiotropium group (Tio: −3.3 ± 17.5 min, Tio/Olo: −72.9 ± 23.1 min, mean difference, −69.7 min, 95% CI −128.7 to −10.6, p = 0.02). There were no differences in terms of age, BMI, CAT score, 6MWD, FEV1, FVC, VC, and physical activity of 1.0-1.5 METs and ≥3.0 METs. Conclusion:This study showed that COPD patients with lower inspiratory capacity or shorter active time of ≥2.0 METs at study entry are likely to exhibit significantly greater reduction in sedentary time with tiotropium/olodaterol treatment.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Reduction of Sedentary Time Following Tiotropium/Olodaterol Therapy in Treatment-Naïve Chronic Obstructive Pulmonary Disease

Takahashi¹,

Tashiro²,

Tajiri³

et al. 2021

COPD

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“…Thus, based on results of other studies with a vast breadth of populations or co-morbidities included [ 32 , 39 – 41 ], we will check the hypothetical premise that 16-weeks of CT program, carried out in a moderate to vigorous intensity, can improve the inflammatory status, insulin resistance and other metabolic risk factors in sedentary office workers. We also look at the hypothetical premise that the CT program will improve lung function [ 20 , 21 , 44 ], stress levels and subjective quality of life [ 24 ]. Moreover, we will check the premise that some changes promoted by the exercise intervention are associated with different variables studied, for example, evidence suggests that most of the benefits of exercise on the inflammatory cytokines seem to be mediated by body composition changes [ 11 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this sense, the participants will have to complete at least three acceptable FVC maneuvers to be included in the analysis (i.e., the difference between the best two FEV 1 and FVC values must be within 150 mL) [ 71 , 72 ]. The best FEV 1 and best FVC measures of the participants will be recorded and used for data analysis, according to procedures adopted in other studies [ 20 , 21 ]. Predicted FEV 1 (FEV 1 % pred), predicted FVC (FVC% pred), and predicted PFE (PFE% pred) will be calculated based on age, stature, ethnicity, and sex using the formulas developed by the Global Lung Function Initiative [ 73 ].…”

Section: Methodsmentioning

confidence: 99%

“…Thus, it seems important to identify those at risk for IR and other risk factors (e.g., abdominal obesity, chronic systemic inflammation) at an early stage [ 18 ]. In addition to the negative impact on metabolic health, an inactive lifestyle also accelerates the age-associated decline in lung function [ 19 – 21 ]. In turn, reduced lung function has been associated with an increase of chronic non-communicable diseases (NCDs) and death [ 19 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thereby, and according to a recent meta-analysis [ 31 ], more studies with CT are required to improve the quality of evidence on this topic. Regarding lung function, cross-sectional studies have shown a positive association between PA levels and lung function among middle-aged adults without a respiratory disease [ 20 , 21 ], however, causal inferences cannot be made. To our knowledge, the effects of a long-term CT exercise program on the lung function of healthy adults have not been examined, with the published studies focusing on adults with obstructive lung diseases [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of combined training on metabolic profile, lung function, stress and quality of life in sedentary adults: A study protocol for a randomized controlled trial

et al. 2022

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Background Both physical inactivity and sedentary behavior are considered modifiable risk factors for chronic diseases and all-cause mortality. Adult office-workers spend most of their working day in sedentary behaviors, so they are particularly at high risk of developed chronic diseases (e.g., cardiovascular diseases, metabolic disorders like diabetes mellitus, …). It seems important to promote behavioral changes that could prevent or delay metabolic disease development. Evidence supports the use of exercise programs, however, to date there are several knowledge gaps and inconsistencies in the literature regarding the effects of Combined Training (i.e., aerobic plus resistance training) in sedentary healthy adults. This paper outlines an RCT designed to evaluate the effects of a 16-week combined training program on biochemical and immune markers of metabolic disease, lung function, salivary stress hormones and subjective quality of life (primary outcomes), as well as on body composition and physical fitness (secondary outcomes) in sedentary middle-aged office-workers. Furthermore, we aimed to assess the associations between the changes promoted by the exercise program and the different variables studied. Methods and design This is a single-blinded two-arm RCT with parallel groups. A minimum of healthy 40 office-workers aged 40–64 years will be recruited to engage in a 16-week intervention study. After baseline assessments, participants will be randomized to one of the two groups: (1) combined training group or (2) control group. Baseline assessments will be repeated after 8 weeks of intervention (mid-testing) and upon completion of the intervention (post-testing). Discussion This RCT involves a multi-disciplinary approach and seems to be a relevant contribution to understanding the potential role of combined training in improving the metabolic profile, lung function, stress, and quality of life in adults. The results can provide important insights for clinical recommendations and for the optimization of strategies to prevent metabolic disorders in adults with sedentary jobs. Trial registration This trial is registered with ClinicalTrials.gov (registration number: NCT04868240; date of registration April 30, 2021).

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Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study

Bahls

Leitzmann

Karch³

et al. 2021

Clin Res Cardiol

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Aims Observational evidence suggests that physical activity (PA) is inversely and sedentarism positively related with cardiovascular disease risk. We performed a two-sample Mendelian randomization (MR) analysis to examine whether genetically predicted PA and sedentary behavior are related to coronary artery disease, myocardial infarction, and ischemic stroke. Methods and results We used single nucleotide polymorphisms (SNPs) associated with self-reported moderate to vigorous PA (n = 17), accelerometer based PA (n = 7) and accelerometer fraction of accelerations > 425 milli-gravities (n = 7) as well as sedentary behavior (n = 6) in the UK Biobank as instrumental variables in a two sample MR approach to assess whether these exposures are related to coronary artery disease and myocardial infarction in the CARDIoGRAMplusC4D genome-wide association study (GWAS) or ischemic stroke in the MEGASTROKE GWAS. The study population included 42,096 cases of coronary artery disease (99,121 controls), 27,509 cases of myocardial infarction (99,121 controls), and 34,217 cases of ischemic stroke (404,630 controls). We found no associations between genetically predicted self-reported moderate to vigorous PA, accelerometer-based PA or accelerometer fraction of accelerations > 425 milli-gravities as well as sedentary behavior with coronary artery disease, myocardial infarction, and ischemic stroke. Conclusions These results do not support a causal relationship between PA and sedentary behavior with risk of coronary artery disease, myocardial infarction, and ischemic stroke. Hence, previous observational studies may have been biased. Graphic abstract

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Effects of replacing sitting time with physical activity on lung function: An analysis of the Canadian Longitudinal Study on Aging

Cited by 15 publications

References 0 publications

Factors Associated with Reduction of Sedentary Time Following Tiotropium/Olodaterol Therapy in Treatment-Naïve Chronic Obstructive Pulmonary Disease

Factors Associated with Reduction of Sedentary Time Following Tiotropium/Olodaterol Therapy in Treatment-Naïve Chronic Obstructive Pulmonary Disease

Effects of combined training on metabolic profile, lung function, stress and quality of life in sedentary adults: A study protocol for a randomized controlled trial

Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study

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