Effects of combined training on metabolic profile, lung function, stress and quality of life in sedentary adults: A study protocol for a randomized controlled trial

Abstract

Background Both physical inactivity and sedentary behavior are considered modifiable risk factors for chronic diseases and all-cause mortality. Adult office-workers spend most of their working day in sedentary behaviors, so they are particularly at high risk of developed chronic diseases (e.g., cardiovascular diseases, metabolic disorders like diabetes mellitus, …). It seems important to promote behavioral changes that could prevent or delay metabolic disease development. Evidence supports the use of exercise programs, however, to date there are several knowledge gaps and inconsistencies in the literature regarding the effects of Combined Training (i.e., aerobic plus resistance training) in sedentary healthy adults. This paper outlines an RCT designed to evaluate the effects of a 16-week combined training program on biochemical and immune markers of metabolic disease, lung function, salivary stress hormones and subjective quality of life (primary outcomes), as well as on body composition and physical fitness (secondary outcomes) in sedentary middle-aged office-workers. Furthermore, we aimed to assess the associations between the changes promoted by the exercise program and the different variables studied. Methods and design This is a single-blinded two-arm RCT with parallel groups. A minimum of healthy 40 office-workers aged 40–64 years will be recruited to engage in a 16-week intervention study. After baseline assessments, participants will be randomized to one of the two groups: (1) combined training group or (2) control group. Baseline assessments will be repeated after 8 weeks of intervention (mid-testing) and upon completion of the intervention (post-testing). Discussion This RCT involves a multi-disciplinary approach and seems to be a relevant contribution to understanding the potential role of combined training in improving the metabolic profile, lung function, stress, and quality of life in adults. The results can provide important insights for clinical recommendations and for the optimization of strategies to prevent metabolic disorders in adults with sedentary jobs. Trial registration This trial is registered with ClinicalTrials.gov (registration number: NCT04868240; date of registration April 30, 2021).

Efeito do treinamento concorrente na composição corporal e perfil metabólico de pessoas obesas: Uma revisão sistemática

“…Os artigos eleitos estão descritos de forma resumida e esquemática no Quadro 3, abaixo, quanto a fonte e data, estudo, desenho experimental, intervenção e resultados. Houve predomínio de obeso do sexo masculino na grande maioria dos estudos sendo um realizou intervenções com mulheres e grande parte dos estudos tinham jovens sedentários também obesos, como amostra total (100% No tocante à porcentagem entre o grupo experimentais que participaram de intervenções de sequência com 12 semanas (Navarro-Lomas et al, 2022;Silva et al, 2022;Ezzati et al, 2021;Mombeyni et al, 2021;Amaro Gahete et al, 2021) 16 semanas (Ferreira et al, 2022), houve diferença, indicando que o TC se faz mais vantajoso para controle dessas variáveis metabólicas, tendo registrado ainda diminuição também em biomarcadores pró-inflamatórios e de estresse oxidativo também em mulheres. Sendo em Moghadam, et al (2022) um diferencial ao usar o açafrão como suplementação associada ao TC, onde está associação se mostrou bastante eficiente em potencializar a resposta anti-inflamatórios decorrentes deste tipo de exercício, podendo este tipo de intervenção com alimentos funcionais ser mais bem estudada, para a obtenção de resultados mais consistentes (Ferreira et al, 2022).…”

“…Os resultados da análise do subgrupo percentual de gordura corporal mostraram que pessoas sem aptidão previa ou treinamento pregresso, homens idosos, foram mais propensos a obter a vantagem durante períodos programados de TC (Bouamra et al, 2022;Ferreira et al, 2022;Moghadam et al, 2022;Navarro-Lomas et al, 2022) e esta vantagem foi relatada logo nas primeiras semanas sendo a 12 semana de intervenção, nitidamente significativa após a 12ª semana (Singh et al, 2022;Silva et al, 2022;Ezzati et al, 2021;Mombeyni et al, 2021). Não houve diferença correlacionadas na porcentagem de cortisol nos períodos estudados, os hormônios séricos entre presentes em (Singh et al, 2022;Silva et al, 2022;Ezzati et al, 2021) Deste modo, com os dados apresentados aqui é possível elucidar muitas dúvidas sobre as respostas fisiológicas provenientes de programas variados de TC para homens obesos sedentários jovens e/ou os de meia idade e ainda os idosos.…”

The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis

“…Sedentary behavior and physical inactivity are now recognized as important causal factors in the development of insulin resistance (IR) and type 2 diabetes (T2DM) 1 , 4 – 6 . Evidence showed that even a short-term (14 days) reduction in physical activity with increased sedentary behavior leads to a reduction in multi-organ insulin sensitivity and muscle insulin sensitivity index, and concomitant increases in central and liver fat and LDL-cholesterol 5 .…”