Effects of repeated administration of deer antler extract on biochemical changes related to aging in senescence-accelerated mice.

Wang, Ben-Xiang; Zhao, Xuehui; Qi, Shang-Bin; Kakeko, Shuji; Hattori, Masao; Namba, T.; Nomura, Yasuyuki

doi:10.1248/cpb.36.2587

Cited by 46 publications

(19 citation statements)

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“…Infrared spectra were recorded on a Bio-Rad FTS 165 spectrometer. NMR spectra were obtained on a Bruker DPX 250 FT NMR spectrometer, determined in CDCl 3 C correlation experiments. The following abbreviations are used: s, singlet; d, doublet; t, triplet; m, multiplet; br, broad; and dd, doublet of doublets.…”

Section: Methodsmentioning

confidence: 99%

Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from Cervus nippon (Deer Antler)

Yang

Kim

Cho

et al. 2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Methodsmentioning

confidence: 99%

Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from Cervus nippon (Deer Antler)

Yang

Kim

Cho

et al. 2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Numerous studies have been performed on the pharmacological effects of deer bone and antler, [11][12][13][14] but most studies were executed using water extraction of deer bone, which produces a large amount of oil remnants that are not well studied. Here, we examined the biological effects of oil fractions from deer bone extraction and performed compositional analysis of the lipids.…”

Section: Discussionmentioning

confidence: 99%

“…11) Water extracts of deer bone or antler have various biological effects, including anti-aging, anti-inflammatory, anti-oxidant, and anti-amnesic activities. [11][12][13][14] However, studies on the biological effects of these deer bone-derived lipids have not yet been investigated. Components of deer bone water extracts include uronic acids and sialic acid as well as components related to protection of cartilage, such as glucosamine, calcium, chondroitin sulfate, and collagen hydrolysate.…”

mentioning

confidence: 99%

Deer Bone Oil Extract Suppresses Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Cells

Hyun-Min

Park

et al. 2016

Biological & Pharmaceutical Bulletin

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The aim of this study was to investigate the effect of deer bone oil extract (DBOE) on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 cells. DBOE was fractionated by liquid-liquid extraction to obtain two fractions: methanol fraction (DBO-M) and hexane fraction (DBO-H). TLC showed that DBO-M had relatively more hydrophilic lipid complexes, including unsaturated fatty acids, than DBOE and DBO-H. The relative compositions of tetradecenoyl carnitine, α-linoleic acid, and palmitoleic acid increased in the DBO-M fraction by 61, 38, and 32%, respectively, compared with DBOE. The concentration of sugar moieties was 3-fold higher in the DBO-M fraction than DBOE and DBO-H. DBO-M significantly decreased LPS-induced nitric oxide (NO) production in RAW264.7 cells in a dose-dependent manner. This DBO-M-mediated decrease in NO production was due to downregulation of mRNA and protein levels of inducible nitric oxide synthase (iNOS). In addition, mRNA expression of pro-inflammatory mediators, such as cyclooxygenase (COX-2), interleukin (IL)-1β, and IL-12β, was suppressed by DBO-M. Our data showed that DBO-M, which has relatively higher sugar content than DBOE and DBO-H, could play an important role in suppressing inflammatory responses by controlling pro-inflammatory cytokines and mediators.

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“…Wang et al (12) suggested that the contents of peroxidized lipid in the liver was higher in SAM-P/8 than in SAM-R/1, although those in brain were similar between them. Furthermore, they demonstrated that deer antler extract, the Japanese name is "Rokujo" , decreased peroxidized lipid con tents in the brain and liver of SAM-P/8 and R/1.…”

Section: Discussionmentioning

confidence: 99%

Effects of Kamikihi-To, a Traditional Chinese Medicine, on Passive and Conditioned Avoidance Performance Impairment in Senescence Accelerated Mouse (SAM)

Nishizawa

Saito

Nishiyama

1990

Japanese Journal of Pharmacology

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Abstract-Effectsof Kamikihi-To (KMK), a traditional Chinese medicine (Chinese name: Jia-Wei-Gui-Pi-Tang), on learning performance impairment caused by aging were evaluated in senescence accelerated mice (SAM). Normal diet con taining 8% KMK extract was given to SAM-P/8, a senile-prone strain, and to SAM R/1, a resistant strain, from 2 months old. Effects of KMK on learning performance were evaluated in 5 and 10 month old SAM using step through and step down type passive avoidance tests and shuttle box and lever press type conditioned avoidance tests.At 5 months old, KMK increased the retention rate in the step through test and decreased the number of errors in the step down test in SAM P/8, though KMK had no effects in conditioned avoidance tests. KMK had no effects in any tests in SAM-R/1.At 10 months old, the decrease of the number of errors in the step down test and increase of the rate of the conditioned avoidance response in the shuttle box test were observed in SAM-P/8 treated with KMK. These results suggest that chronic administration of KMK can improve learning performance in the senescence model.

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Effects of repeated administration of deer antler extract on biochemical changes related to aging in senescence-accelerated mice.

Cited by 46 publications

References 1 publication

Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from Cervus nippon (Deer Antler)

Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from Cervus nippon (Deer Antler)

Deer Bone Oil Extract Suppresses Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Cells

Effects of Kamikihi-To, a Traditional Chinese Medicine, on Passive and Conditioned Avoidance Performance Impairment in Senescence Accelerated Mouse (SAM)

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