Effects of renal failure

Wills, M. R.

doi:10.1016/0009-9120(90)90453-2

Cited by 17 publications

(13 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serum levels of total bilirubin (Walter and Gerarade, 1970), total proteins (Henary, 1974) and albumin (Doumas et al, 1971) were also assayed. Serum concentrations of urea (Wills and Savory, 1981) and creatinine (Kroll et al, 1987) were determined colorimetrically as measures of kidney functions.…”

Section: Chemical Studymentioning

confidence: 99%

Anti‐Ulcerative Colitis Activity of Compounds from Euphorbia granuleta Forssk

Awaad

El‐Meligy

Al-Jaber

et al. 2013

Phytotherapy Research

View full text Add to dashboard Cite

The aim of the present study was to evaluate the anti-ulcerative colitis (UC) activity of the total alcohol extracts of Euphorbia granuleta Forssk. (Euphorpiaceae), isolate and identify the active compounds that could be responsible for the activity, in addition to determination of the possible mechanism of action. Six compounds were isolated and identified from this plant: three phenolic compounds (kampferol, kampferol-3-glucoside and kampferol-3-galactoside) in addition to three steroidal compounds (1-ethoxypentacosane, heptacosan-1-ol and β-sitosterol). Three compounds (heptacosan-1-ol, β-sitosterol and kampferol-3-galactoside) were found to be responsible for the anti-UC activity of E. granuleta extract. The anti-UC activity of these compounds may be explained by reducing the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α), in addition to reduction of colonic malondialdehyde (MDA) contents. No side effects were reported on liver and kidney functions. The active compounds reduced both serum TNF-α and mucosal MDA levels.

show abstract

Section: Chemical Studymentioning

confidence: 99%

Anti‐Ulcerative Colitis Activity of Compounds from Euphorbia granuleta Forssk

Awaad

El‐Meligy

Al-Jaber

et al. 2013

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Chronic renal failure can be manifested in a variety of symptoms such as accelerated aging, atherosclerosis, heart disease, polyneuropathy and amyloidosis [13], which are presumably related to the hyperproduction of free radicals. A free radical attack on cell membrane polyunsaturated fatty acids results in the formation of lipid peroxidation products such as conjugated dienes and malonylaldehyde, which accumulate in the erythrocytes of hemodialysis and CAPD patients and are indirect indicators of ROS exposure [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Extracellular Superoxide Dismutase in Hemodialysis Patients

Yamada

Adachi

et al. 2000

Nephron

View full text Add to dashboard Cite

Background: The superoxide anion and other oxygen radicals have been implicated in the progression of chronic renal failure, and are removed by extracellular superoxide dismutase (EC-SOD) in the extracellular space on the surface of the endothelium. A single-base substitution of the EC-SOD gene which reduces the binding capability to endothelial cells resulting in an increased serum concentration, has been identified in healthy persons and hemodialysis patients. Results: The proportion of patients with this mutation among hemodialysis patients in each 20 months’ duration after the initiation of hemodialysis was retrospectively studied. The percentage of substitution-positive patients declined 80 months after the start of hemodialysis in non-DM patients. In contrast, in DM patients, the rapid decrease was obvious as early as 40 months after the initiation of hemodialysis. By prospective study for 5 years, there were significant differences in the survival rate between patients with and without R213G in DM, but not in non-DM patients. Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G. Conclusion: These results suggest that the presence of a substitution in the EC-SOD gene at the heparin-binding domain could be a prognostic marker of dialysis patients.

show abstract

“…The biological factors associated with depression in these patients may include physiological and biochemical effects of uremia. 3,4,19–24 …”

Section: Discussionmentioning

confidence: 99%

“…The biological factors associated with depression in these patients may include physiological and biochemical effects of uremia. 3,4,[19][20][21][22][23][24] In the present study, we administered the Zung SDS to 19 renal failure patients who were treated with haemodialysis. The SDS scores of these patients significantly decreased after introduction to haemodialysis.…”

Section: Discussionmentioning

confidence: 99%