Application of the Zung self‐rating depression scale to patients before and after introduction to haemodialysis

Matsui, Hideki; Kitagami, Tomitsune; Ohta, Tetsuo

doi:10.1046/j.1440-1819.1999.00561.x

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…A cut-off of equal to and higher than 60/100 was considered as indicative for diagnosable depression [18] . Cognitive-depressive and vegetative-depressive symptom dimensions were constructed as described earlier [19] . The vegetative-depressive symptoms (Diurnal variation, lack of sleep, loss of appetite, loss of sex drive, weight loss, constipation, fatigue) were scored from 1 to 4 (in the analysis multiplied with 5/4).…”

Section: Risk Determinationmentioning

confidence: 99%

Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

Robaeys

Bie²,

Wichers

et al. 2007

WJG

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sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION:In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. INTRODUCTIONFollowing the recent expert consensus, patients with chronic hepatitis C (CHC) should now receive interferon (IFN) and ribavirin regardless of psychiatric status, except in uncontrolled psychiatric disease [1][2][3] . As 23%-44% of patients treated with IFN develop depressive symptoms during treatment [4,5] and since, more patients are treated, interferon-induced psychiatric illness is likely to become an increasingly important clinical problem [4,[6][7][8][9][10][11][12][13][14] . IFN-induced depression appears to be a depressive disorder that is unusually responsive to antidepressant treatment. Approximately 80% of patients are responsive within 4 wk [15] . This high response rate may be related to the usually short duration of this illness when treatment is initiated, to the mild to moderate severity of illness in most cases [1] , but also to the mainly interferon-induced influences on the central nervous system [16] . Based on the results of a small scale study (n = 16), it has been hypothesised that vegetative symptoms are Abstract AIM: To study the predictive value of the vegetativedepressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS:T h e pre dic t ive value of ve ge t at ivedepressive symptoms at 4 wk of treatment for the o c c u r r e n c e o f a s u b s e q u e n t d i a g n o s i s o f m a j o r depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multicenter treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS:Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The

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Section: Risk Determinationmentioning

confidence: 99%

Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

Robaeys

Bie²,

Wichers

et al. 2007

WJG

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“…In Japan, the self‐rating depression scale of Zung et al. is reportedly used to evaluate dialysis patients (10). This scale must be verified in the future.…”

mentioning

confidence: 99%

Diagnosis and Treatment of Depression in Dialysis Patients

Kimura

Ozaki

2006

Ther Apher Dial

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A high prevalence of depressive disorder, between 33% and 50%, has been reported in dialysis patients, although it is difficult to distinguish the physical symptoms like general fatigue, insomnia, and loss of appetite which are common among dialysis patients, from the psychiatric symptoms seen in depressive patients. Furthermore, co-occurrence of depression has been shown to be one of the risk factors of poor prognosis in dialysis patients, partly because depressed patients are less likely to adhere to their medication regimen and modify their lifestyle appropriately. The efficacy of psychiatric interventions, including pharmacotherapy and psychotherapy, has been examined for dialysis patients with co-occurrence of depression. Randomized controlled trials of psychiatric interventions for depression in dialysis patients are needed to investigate the impact of such interventions on depression, quality of life, and mortality.

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“…The Zung Self-Rating Depression Scale was used to assess levels of depression. This questionnaire is very sensitive to the early signs of depression and has been previously used in hemodialysis patients (41).…”

Section: Methodsmentioning

confidence: 99%

Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients

Sakkas¹,

Karatzaferi²,

Ζιντζαράς³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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The aim of this study was to identify contributors to IR and to develop a model for predicting glucose intolerance in nondiabetic hemodialysis patients. After a 2-h, 75-g oral glucose tolerance test (OGTT), 34 hemodialysis patients were divided into groups with normal (NGT) and impaired glucose tolerance (IGT). Indices of insulin sensitivity were derived from OGTT data. Measurements included liver and muscle fat infiltration and central adiposity by computed tomography scans, body composition by dual energy X-ray absorptiometer, sleep quality by full polysomnography, and functional capacity and quality of life (QoL) by a battery of exercise tests and questionnaires. Cut-off points, as well as sensitivity and specificity calculations were based on IR (insulin sensitivity index by Matsuda) using a receiver operator characteristics (ROC) curve analysis. Fifteen patients were assigned to the IGT, and 19 subjects to the NGT group. Intrahepatic fat content and visceral adiposity were significantly higher in the IGT group. IR indices strongly correlated with sleep disturbances, visceral adiposity, functional capacity, and QoL. Visceral adiposity, O 2 desaturation during sleep, intrahepatic fat content, and QoL score fitted into the model for predicting glucose intolerance. A ROC curve analysis identified an intrahepatic fat content of Ͼ3.97% (sensitivity, 100; specificity, 35.7) as the best cutoff point for predicting IR. Visceral and intrahepatic fat content, as well as QoL and sleep seemed to be involved at some point in the development of glucose intolerance in hemodialysis patients. Means of reducing fat depots in the liver and splachnic area might prove promising in combating IR and cardiovascular risk in hemodialysis patients.insulin sensitivity index by Matsuda; homeostasis assessment model of insulin resistance; functional capacity; oral glucose insulin sensitivity; quality of life; quantitative insulin-sensitivity check index

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Application of the Zung self‐rating depression scale to patients before and after introduction to haemodialysis

Abstract: In the present study we applied

Cited by 9 publications

References 19 publications

Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

Diagnosis and Treatment of Depression in Dialysis Patients

Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients

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