Effects of Prostaglandins E1 and F1α Upon Carbohydrate Metabolism of Ejaculated and Epididymal Ram Spermatozoa In Vitro

Prostaglandins in Semen: Their Occurrence and Possible Physiological Significance

“…However, 19-OH PGE is the predominant PG in monkey semen, and the 19-OH E to E ratio is around 1OO:l . When the effects of PGE and PGF were tested on epididymal sheep spermatozoa, the rate of glycolysis was significantly raised by both PGs (Pento et al 1970); hcwever, nc significant effects of PGs were observed on washed, ejaculated sheep spermatozoa (Pento et al 1970) 01' washed, ejaculated human spermatozoa (Eliasscn et al 1968). When an extract containing 19-OH PGEs or synthetic 19-OH PGEl (racemic and mixed 19 epimers) was tested on washed ejaculated human spermatozoa, a lowered production of labelled carbon dioxide from 14C fructose was observed (Kelly 1977) which might explain the almost complete absence of the Pasteur effect in human semen (Eliasson 1971).…”

Effects of phosphodiesterase inhibitors and cyclic nucleotides on sperm respiration and motility

“…In the presence of pyruvate or glucose, prostaglandins Ei" Ei, and Ez, at 20 Mg/ml, caused no stimulation of oxygen consumption, and sperm motility was unaffected. Pento et al (1970) had previously reported no stimulation of ram epididymal sperm respiration by prostaglandins in the presence of glucose. Prostaglandin Ei at levels of 20 or 40 /ig per ml caused no detectable change in CAMP levels of spermatozoa figure 2: The effects of diCAMP and CGMP on bovine epididymal sperm respiration.…”

The Effect of Prostaglandin E1 on Rabbit Sperm Transport in Vivo

“…Hawkins & Labrum (1961) found no correlation between the amount of prostaglandin in the semen and human sperm density or the rate of decline of sperm motility, though they did find a relationship between low prostaglandin levels and a high incidence of abnormal spermatozoa. More recently, Pento, Cenedella & Inskeep (1970) found that prostaglandins had no effect on the carbohydrate metabolism of ejaculated ram spermatozoa. The hypothesis of Goldblatt (1935) that prostaglandins contribute to vasodilatation in the male genital tract at the time of coitus lacks support.…”