2020
DOI: 10.1590/0102-672020190001e1498
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Abstract: Background: Chronic wounds in patients with Diabetes Mellitus often become incurable due to prolonged and excessive production of inflammatory cytokines. The use of probiotics modifies the intestinal microbiota and modulates inflammatory reactions. Aim: To evaluate the influence of perioperative supplementation with probiotics in the cutaneous healing process in diabetic rats. Methods: Forty-six rats were divided into four groups (C3, P3, C10, P10) according to the treatment (P=probiotic or C=control, b… Show more

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Cited by 11 publications
(48 citation statements)
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References 27 publications
(48 reference statements)
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“…In the study by Campos et al 22 , a correlation was observed between higher blood glucose values and lower weight in diabetic animals, indicating that the body's inability to use glucose due to insulin resistance leads to a catabolic condition.…”
Section: Discussionmentioning
confidence: 93%
“…In the study by Campos et al 22 , a correlation was observed between higher blood glucose values and lower weight in diabetic animals, indicating that the body's inability to use glucose due to insulin resistance leads to a catabolic condition.…”
Section: Discussionmentioning
confidence: 93%
“…Many animal-model studies that focused on DM have clearly demonstrated the beneficial effects of probiotic strains [ 62 ]. Patients with DM usually have impairment in healing due to an imbalance of the wound-healing process [ 63 ]. The wound-healing process includes haemostasis, inflammation, and proliferative and remodelling procedures [ 64 ].…”
Section: Resultsmentioning
confidence: 99%
“…Campos et al investigated the effects of probiotic supplements on skin wounds in diabetic rats [ 63 ]. The DM rats ( n = 46) started the preoperative probiotic or placebo supplementation eight days before surgery.…”
Section: Resultsmentioning
confidence: 99%
“…Antibiotic prophylaxis does not replace any of the other preventive care of SSI and should not be seen in isolation in preventing it, but rather as part of a set of factors based on both the patient and the surgical procedures. Examples of the former may be extremes of age, immunosuppression, diabetes mellitus 12 , perioperative glycemic control, chronic disease 14 , smoking, prolonged hospitalization, MRSA (methicillin-resistant Staphylococcus aureus ) colonization, coexisting infections in other locations, poor nutritional status or obesity. Factors inherent to the procedures include skin antisepsis, correct surgical technique, adequate hemostasis, maintenance of body temperature, operating time, sterilization of surgical materials and equipment, and positive pressure ventilation in the operating room 13 , 17 , 26 .…”
Section: Resultsmentioning
confidence: 99%