Effects of Preservative-Free Artificial Tear Solutions on Corneal Epithelial Structure and Function

Ubels, John L.; McCartney, Mitchell D.; Lantz, William K.; Beaird, Jonnell; Dayalan, Ashim; Edelhauser, Henry F.

doi:10.1001/archopht.1995.01100030127036

Cited by 67 publications

(31 citation statements)

References 18 publications

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“…7,8 In this method the corneal epithelium is damaged by a brief exposure to 0.01% benzalkonium chloride 9 which increases the permeability of the epithelium to 5, 6 carboxyfluorescein (CF). 10 The cornea is then exposed to an artificial tear for 1.5 hours during which time the epithelium may recover from damage as indicated by a decrease in uptake of CF.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous studies we were able to distinguish among artificial tear formulations of varying preservative content and electrolyte composition using this method. 7,8 We have now employed this method for evaluation of the new PEG/PG/HP-guar formulation and compared its efficacy the formulation without HP-guar and a commercial tear product.…”

Section: Introductionmentioning

confidence: 99%

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Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent

Ubels

Clousing

Haitsma

et al. 2004

Current Eye Research

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The tear product containing HP-guar, PEG 400 and propylene glycol satisfies several pre-clinical criteria for an appropriate artificial tear formulation. It gives long-term desiccation protection of the intact cornea and also epithelial cells in culture and has no apparent deleterious affects on cells. It also provides conditions in which a damaged corneal epithelium can recover normal barrier function. The combination of ingredients in the formulation appears to provide an effective mucomimetic artificial tear product. These pre-clinical data suggest that the product will be effective in providing superior relief for the dry eye sufferer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent

Ubels

Clousing

Haitsma

et al. 2004

Current Eye Research

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“…An ideal lacrimomimetic must provide an environment compatible with the maintenance of the ocular physiology and must support epithelial healing (UBELS et al, 1995). Among the available options, special attention should be given to the lubricating agents and to some of their key properties: electrolyte composition, osmolarity, and presence of preservatives (GRAHN & STOREY, 2004).…”

Section: Developmentmentioning

confidence: 99%

“…Sodium bicarbonate is frequently added to ophthalmic solutions as a buffer and provided a mildly alkaline pH (DOGRU et al, 2013). Besides its activity as a physiological buffer solution, the bicarbonate molecules also play a role in regenerating the epithelial barrier and maintaining the corneal ultra structure (UBELS et al, 1995;DOGRU et al, 2013). Other buffers include proteins, phosphate, acetate, and borate (DOGRU et al, 2013).…”

Section: Properties Of the Lacrimomimeticsmentioning

confidence: 99%

Ocular lubricants: what is the best choice?

Araújo

Galera

2016

Cienc. Rural

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“…Filamentary keratitis can be exacerbated by preservatives in artificial tears that may increase cellular exfoliation and cytotoxic changes of the corneal epithelium,which in turn can lead to the formation of new filament receptor sites [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis

Liu

et al. 2010

j ocul biol dis inform

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This study aims to investigate the efficacy of lacrimal plugs combined with deproteinized calf blood extract eye gel on the treatment of dry-eye-associated filamentary keratitis. Lacrimal plugs were inserted into both the upper and lower puncta of 15 patients (28 eyes). Deproteinized calf blood cxtract eye gel was applied in two patients who were not cured after this operation. All patients were asked to complete three questionnaires 1 day before the surgery and at 1 week and 1 month after the surgery. Ophthalmologic examinations were carried out and repeated at 1 day and at 1 week and 1 month after plug insertion, which include fluorescein staining, tear break-up time (BUT), Schirmer test I (STI), corneal confocal microscope (HRT-III), and impression cytology (IC). Symptoms were relieved in all patients 1 month after the application of lacrimal plugs. Deproteinized calf blood extract eye gel was applied to two patients whose symptoms remained after lacrimal plug implantation for 1 week. At 3 weeks later, the symptoms disappeared and cornea fluorescein stain was hardly identified. The lacrimal river in all patients became broader after the surgery, 11 of whom reached 0.3 mm. Cornea filamentary disappeared in all patients. The average of BUT and ST were increased to 7.50 ± 1.897 s (p < 0.001) and 8.12 ± 1.996 mm at 1 week after the operation and 7.94 s and 9.00 ± 1.897 mm at 1 month later, respectively. Photography from HRT-III suggested that the state of corneal epithelium was markedly improved, including the squamous metaplasia of the epithelial layer of the cornea and the bend of nerve fibers under the corneal epithelium. IC also suggested that the squamous metaplasia of epithelial layer of conjunctiva in these patients was improved. The symptoms of patients suffering from severe filamentary keratitis were remarkably relieved by using lacrimal plugs, which could increase the tear volume of the ocular surface, improve the condition of tear film, and promote the recovery of corneal diseases. For patients with more severe symptoms, additional usage of deproteinized calf blood extract eye gel could assist the treatment. Therefore, lacrimal plugs combined with deproteinized calf blood extract eye gel are suggested to be an effective method to treat severe filamentary keratitis.

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Effects of Preservative-Free Artificial Tear Solutions on Corneal Epithelial Structure and Function

Cited by 67 publications

References 18 publications

Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent

Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent

Ocular lubricants: what is the best choice?

Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis

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