Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis

Abstract

This study aims to investigate the efficacy of lacrimal plugs combined with deproteinized calf blood extract eye gel on the treatment of dry-eye-associated filamentary keratitis. Lacrimal plugs were inserted into both the upper and lower puncta of 15 patients (28 eyes). Deproteinized calf blood cxtract eye gel was applied in two patients who were not cured after this operation. All patients were asked to complete three questionnaires 1 day before the surgery and at 1 week and 1 month after the surgery. Ophthalmologic examinations were carried out and repeated at 1 day and at 1 week and 1 month after plug insertion, which include fluorescein staining, tear break-up time (BUT), Schirmer test I (STI), corneal confocal microscope (HRT-III), and impression cytology (IC). Symptoms were relieved in all patients 1 month after the application of lacrimal plugs. Deproteinized calf blood extract eye gel was applied to two patients whose symptoms remained after lacrimal plug implantation for 1 week. At 3 weeks later, the symptoms disappeared and cornea fluorescein stain was hardly identified. The lacrimal river in all patients became broader after the surgery, 11 of whom reached 0.3 mm. Cornea filamentary disappeared in all patients. The average of BUT and ST were increased to 7.50 ± 1.897 s (p < 0.001) and 8.12 ± 1.996 mm at 1 week after the operation and 7.94 s and 9.00 ± 1.897 mm at 1 month later, respectively. Photography from HRT-III suggested that the state of corneal epithelium was markedly improved, including the squamous metaplasia of the epithelial layer of the cornea and the bend of nerve fibers under the corneal epithelium. IC also suggested that the squamous metaplasia of epithelial layer of conjunctiva in these patients was improved. The symptoms of patients suffering from severe filamentary keratitis were remarkably relieved by using lacrimal plugs, which could increase the tear volume of the ocular surface, improve the condition of tear film, and promote the recovery of corneal diseases. For patients with more severe symptoms, additional usage of deproteinized calf blood extract eye gel could assist the treatment. Therefore, lacrimal plugs combined with deproteinized calf blood extract eye gel are suggested to be an effective method to treat severe filamentary keratitis.

Epithelial changes with corneal punctate epitheliopathy in type 2 diabetes mellitus and their correlation with time to healing

“…The therapy for CPE was standardized and included sodium hyaluronate eye drops and de-proteinized calf blood extract eye gel 4 times a day [ 25 ]. All patients were examined within 3-7 days of the initiation of treatment and at a similar interval thereafter untill healing was complete.…”

Clinical effect of deproteinized calfblood extract eye gel for corneal epithelial defect

“…[9] Deproteinized calfblood extract can significantly alleviate the irritating sensation caused by corneal ulcer; it remains to be unknown whether this extract has an effect on the promotion of corneal neovascularization. [10] Studies have confirmed that [11,12] the application of deproteinized calfblood extract to eyes can improve local hypoxia and ischemic conditions and promote the repair and regeneration of nerve tissues, which is beneficial to the repair of corneal epithelium injury caused by surgery and inflammation. The eye gel, formulated with carboxymethyl cellulose sodium, can pro-long the contact time of drug with the ocular surface, deploy medicinal properties of deproteinized calfblood extract to the greatest effect, simultaneously lubricate the cornea and effectively improve the comfort degree of medication.…”

Early Complications After Penetrating Keratoplasty

“…20,[22][23][24][25] Punctal occlusion, blepharoplasty, botulinum toxin for temporary tarsorrhaphy, and soft bandage contact lens may also be used depending on the cause of the FK. [26][27][28]…”