Effects of pre- or post-training paradoxical sleep deprivation on two animal models of learning and memory in mice

The effects of rapid eye movement sleep deprivation and recovery on spatial reference memory of young rats

“…For example, Ishikawa et al specifically examined the effect of RSD after LTP induction and REM rebound on LTP maintenance in DG; it was shown that a 24-to 48-h duration of RSD caused a significant decrease in population spike amplitudes and that REM rebound has no effect on RSD-induced impairment of LTP. RomcyPereira and Pavlides focused on the effects of RSD following LTP induction, reporting that a 4-h RSD immediately after a high frequent stimulus (HFS) induced LTP et al, 2006;Marshall & Born, 2007;Saxvig et al, 2008;R. H. Silva et al, 2004;Stickgold, 2005;Walker & Stickgold, 2004.…”

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

“…PM-DAT complies with ethical protocols since there is no foot shock, which is imposed by classical avoidance tests. Considering the effects of PSD in mice submitted to the PM-DAT (Silva et al 2004b), pre-training PSD-induced anxiogenic and hypolocomotor effects were observed in the training session, but they did not modify the acquisition of the task.…”

“…If sleep is essential for health and life, then sleep deprivation is a biological stressor. Indeed, some signs of sleep deprivation are weight loss, reduced thymus weight (Coenen and Van Luijtelaar 1985), increased adrenal weight Van Luijtelaar 1985, Suchecki and, augmented corticosterone (Suchecki and Tufik 2000, Andersen et al 2003c, 2004b, d, 2005a, Hipólide et al 2006, and ACTH levels (Andersen et al 2005a). Sleep deprivation produces a marked negative energy balance, indicating that hypercatabolism is a central effect of sleep deprivation in rats (Everson 1997) in addition to termorregulation alteration (Seabra andTufik 1993, Hoshino 1996).…”

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

“…Sleep deprivation was carried out for 72 h using the modified multiple platform method [19,20,21,22,23,24,25,26,27], which consists of placing 5 mice in a ventilated cage (38 × 31 × 17 cm; Tecniplast, Buguggiate, Italy) containing 14 circular platforms (3.5 cm in diameter) with water 1 cm below the upper surface. At the onset of each paradoxical sleep episode, the animal experiences a loss of muscle tonus and falls into the water, thus awakening.…”