The effects of rapid eye movement sleep deprivation and recovery on spatial reference memory of young rats

Li, Shenghui; Tian, Ying; Ding, Yu; Jin, Xinming; Yan, Chen‐Hua; Shen, Xiaoming

doi:10.3758/lb.37.3.246

Cited by 32 publications

(22 citation statements)

References 40 publications

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“…While other studies of short and long bouts of REM sleep deprivation described associated deficits in Morris water maze spatial learning Rose 1996, 1997;Youngblood et al 1997;Yang et al 2008;Li et al 2009;Wang et al 2009), they differed on variables reported, and the findings sometimes conflicted. These inconsistencies across studies may be a result of variances within the protocols used, such as the period of REM sleep deprivation or the exact training procedure in the Morris water maze.…”

Section: Factors Contributing To Lack Of Concurrent Rem Sleep Deprivamentioning

confidence: 92%

“…However, previous research on adrenalectomized rats who cannot mount the stress response still showed sleep deprivation-associated performance deficits, indicating that such deficits are likely not a result of the stress related to the deprivation technique itself (Ruskin et al 2006). Further, both Li et al (2009) andWang et al (2009) found REM sleep deprivation-associated deficits in spatial learning even with multiple platforms within the deprivation chambers. Therefore, the difference between our findings and those previously reported were likely not the result of variances in the deprivation chambers.…”

Section: Factors Contributing To Lack Of Concurrent Rem Sleep Deprivamentioning

confidence: 94%

“…Though the deprivation chamber we used was similar to that used in experiments which showed REM sleep deprivation-associated spatial learning impairments in other tasks (Bjorness et al 2005;Ravassard et al 2009), we used a lower water level within our deprivation chamber than that used in previous Morris water maze/REM sleep deprivation studies (Table 1; Rose 1996, 1997;Youngblood et al 1997;Yang et al 2008;Li et al 2009;Wang et al 2009). Therefore, we retested the effects of REM sleep deprivation on 12 trials/day concurrent with spatial learning and subsequent reversal learning using a high level of water within the deprivation chamber.…”

Section: Experiments 1-rem Sleep Deprivation Effects On Concurrent Revmentioning

confidence: 99%

“…To date, there has been much controversy on whether learning is facilitated by REM sleep (Fishbein 1971;Pearlman 1973;Leconte et al 1974;Fishbein and Gutwein 1977;Gutwein and Fishbein 1980a,b;Smith and Butler 1982;Hars et al 1985;Smith 1985Smith , 1995Smith and Lapp 1991;Smith and Wong 1991;Hennevin et al 1995;Rose 1996, 1997;Youngblood et al 1997;Smith et al 1998;Poe et al 2000;Le Marec et al 2001;Bjorness et al 2005;Silvestri 2005;Fu et al 2007;Yang et al 2008;Li et al 2009;Wang et al 2009) or is independent of REM sleep (Albert et al 1970;Miller et al 1971;Sloan 1972;McGrath and Cohen 1978;Shiromani et al 1979;Van Hulzen and Coenen 1979;Horne and McGrath 1984;Smith 1985;Horne 1988;Yang et al 2008). Only a few studies have focused on the effect of REM sleep deprivation on the consolidation of spatial learning Rose 1996, 1997;Youngblood et al 1997;Bjorness et al 2005;Yang et al 2008;Li et al 2009;Wang et al 2009).…”

Section: Is Rem Sleep Essential For Learning?mentioning

confidence: 99%

“…Increases in REM sleep have been described following learning (e.g., Lucero 1970;Hennevin et al 1971;Leconte and Hennevin 1971;Fishbein et al 1974;Smith et al 1980;Smith and Butler 1982;Smith and Lapp 1986;Portell-Cortes et al 1989;Smith and Wong 1991;Bramham et al 1994;Smith and Rose 1997;Mavanji and Datta 2003) that imply a functional relationship. Some studies suggest that REM sleep is tightly linked with specific types of learning such as spatial learning (e.g., Rose 1996, 1997;Youngblood et al 1997;Smith et al 1998;Beaulieu and Godbout 2000;Le Marec et al 2001;Bjorness et al 2005;Ruskin et al 2006;Yang et al 2008;Li et al 2009;Wang et al 2009), which is hippocampus-dependent.…”

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confidence: 99%

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Spatial and reversal learning in the Morris water maze are largely resistant to six hours of REM sleep deprivation following training

Walsh

Booth²,

Poe³

2011

Learn. Mem.

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This first test of the role of REM (rapid eye movement) sleep in reversal spatial learning is also the first attempt to replicate a much cited pair of papers reporting that REM sleep deprivation impairs the consolidation of initial spatial learning in the Morris water maze. We hypothesized that REM sleep deprivation following training would impair both hippocampusdependent spatial learning and learning a new target location within a familiar environment: reversal learning. A 6-d protocol was divided into the initial spatial learning phase (3.5 d) immediately followed by the reversal phase (2.5 d). During the 6 h following four or 12 training trials/day of initial or reversal learning phases, REM sleep was eliminated and non-REM sleep left intact using the multiple inverted flowerpot method. Contrary to our hypotheses, REM sleep deprivation during four or 12 trials/day of initial spatial or reversal learning did not affect training performance. However, some probe trial measures indicated REM sleep-deprivation-associated impairment in initial spatial learning with four trials/ day and enhancement of subsequent reversal learning. In naive animals, REM sleep deprivation during normal initial spatial learning was followed by a lack of preference for the subsequent reversal platform location during the probe. Our findings contradict reports that REM sleep is essential for spatial learning in the Morris water maze and newly reveal that short periods of REM sleep deprivation do not impair concurrent reversal learning. Effects on subsequent reversal learning are consistent with the idea that REM sleep serves the consolidation of incompletely learned items.While it has been widely shown that both total sleep deprivation and sleep fragmentation impair learning, there remains much debate over the role of REM sleep deprivation for learning (for reviews, see Smith 1995;Hobson and Pace-Schott 2002;Vertes 2004;Rauchs et al. 2005;Stickgold and Walker 2005;Vertes and Siegel 2005). Increases in REM sleep have been described following learning (e.g., Lucero 1970;Hennevin et al. 1971;Leconte and Hennevin 1971;Fishbein et al. 1974;Smith et al. 1980;Smith and Butler 1982;Smith and Lapp 1986;Portell-Cortes et al. 1989;Smith and Wong 1991;Bramham et al. 1994;Smith and Rose 1997;Mavanji and Datta 2003) that imply a functional relationship. Some studies suggest that REM sleep is tightly linked with specific types of learning such as spatial learning (e

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Section: Factors Contributing To Lack Of Concurrent Rem Sleep Deprivamentioning

confidence: 92%

Section: Factors Contributing To Lack Of Concurrent Rem Sleep Deprivamentioning

confidence: 94%

Section: Experiments 1-rem Sleep Deprivation Effects On Concurrent Revmentioning

confidence: 99%

Section: Is Rem Sleep Essential For Learning?mentioning

confidence: 99%

mentioning

confidence: 99%

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Spatial and reversal learning in the Morris water maze are largely resistant to six hours of REM sleep deprivation following training

Walsh

Booth²,

Poe³

2011

Learn. Mem.

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Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise

Zielinski

Gerashchenko

2015

Diet and Exercise in Cognitive Function and Neurological Diseases

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Animal Studies on the Role of Sleep in Memory: From Behavioral Performance to Molecular Mechanisms

Havekes

Meerlo

Abel

2015

Current Topics in Behavioral Neurosciences

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Although the exact functions of sleep remain a topic of debate, several hypotheses propose that sleep benefits neuronal plasticity, which ultimately supports brain function and cognition . For over a century, researchers have applied a wide variety of behavioral, electrophysiological, biochemical, and molecular approaches to study how memory processes are promoted by sleep and perturbed by sleep loss. Interestingly, experimental studies indicate that cognitive impairments as a consequence of sleep deprivation appear to be most severe with learning and memory processes that require the hippocampus , which suggests that this brain region is particularly sensitive to the consequences of sleep loss. Moreover, recent studies in laboratory rodents indicate that sleep deprivation impairs hippocampal neuronal plasticity and memory processes by attenuating intracellular cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling. Attenuated cAMP-PKA signaling can lead to a reduced activity of the transcription factor cAMP response element binding protein (CREB) and ultimately affect the expression of genes and proteins involved in neuronal plasticity and memory formation. Pharmacogenetic experiments in mice show that memory deficits following sleep deprivation can be prevented by specifically boosting cAMP signaling in excitatory neurons of the hippocampus. Given the high incidence of sleep disturbance and sleep restriction in our 24/7 society, understanding the consequences of sleep loss and unraveling the underlying molecular mechanisms is of great importance.

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The effects of rapid eye movement sleep deprivation and recovery on spatial reference memory of young rats

Cited by 32 publications

References 40 publications

Spatial and reversal learning in the Morris water maze are largely resistant to six hours of REM sleep deprivation following training

Spatial and reversal learning in the Morris water maze are largely resistant to six hours of REM sleep deprivation following training

Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise

Animal Studies on the Role of Sleep in Memory: From Behavioral Performance to Molecular Mechanisms

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