Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Maragno-Correa, Jussara M. R.; Patti, Camilla L.; Zanin, Karina A.; Wuo-Silva, Raphael; Ruiz, Francieli Silva; Zager, Adriano; Sá-Nunes, Anderson; Tufik, Sérgio; Andersen, Mônica Levy; Frussa‐Filho, Roberto

doi:10.1159/000346201

Cited by 22 publications

(13 citation statements)

References 37 publications

(41 reference statements)

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“…A similar result associated with physical activity and SD was observed in mice that spontaneously formed polyps associated with the development of colorectal cancer [23]. Maragno-Correa et al [15] observed that mice inoculated with Ehrlich's tumor and deprived of sleep for 72 h using the multiple-platform method exhibited no change in tumor development, but did exhibit a reduction in survival rate.…”

Section: Discussionsupporting

confidence: 53%

“…Some experimental studies evaluated the effect of SD on tumor development. For example, Maragno-Correa et al [15] observed that mice inoculated with Ehrlich's tumor and deprived of sleep for 72 h (using the multiple-platform method) exhibited no change in tumor development, but did exhibit a reduction in survival rate. Hakim et al [16] demonstrated that sleep fragmentation, a condition observed in people who suffer from sleep apnea, enhances tumor size, and favors an increased number of tumor-associated macrophages which are known to produce suppressive factors and provide inhibitory signals to cells in the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Sleep Restriction Impairs the Antitumor Immune Response in Mice

Lorenzo

Brito

Leal

et al. 2018

Neuroimmunomodulation

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Objectives: Sleep regulates immune function reciprocally and can affect the parameters that are directly involved in the immune response. Sleep deprivation is considered to be a stress-causing factor and is associated with impaired immune activity. It causes increased glucocorticoid concentrations by activating the hypothalamic-pituitary-adrenal axis; this can lead to a series of disorders that are associated with the prolonged or increased secretion of these hormones. The aim of this study was to evaluate the effects of sleep restriction (SR) on the development of pulmonary experimental metastasis and the modulation of the tumor immune response. Methods: The SR protocol was accomplished by depriving C57BL/6 male mice of sleep for 18 h/day for 2, 7, 14, and 21 days. The modified multiple-platforms method was used for SR. Results: The results showed that cytotoxic cells (i.e., natural killer [NK] and CD8+ T cells) were reduced in number and regulatory T cells were predominant in the tumor microenvironment. Sleep-restricted mice also exhibited a reduced number of dendritic cells in their lymph nodes, which may have contributed to the ineffective activation of tumor-specific T cells. Peripheral CD4+ and CD8+ T cells were also reduced in the sleep-restricted mice, thus indicating an immunosuppressive status. Conclusions: Sleep deprivation induces failure in the activity of cells that are important to the tumor immune response, both in the tumor microenvironment and on the periphery. This leads to the early onset and increased growth rate of lung metastasis.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Chronic Sleep Restriction Impairs the Antitumor Immune Response in Mice

Lorenzo

Brito

Leal

et al. 2018

Neuroimmunomodulation

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“…Lange et al () have shown that individuals who had regular sleep after vaccination against hepatitis A had antibody titers nearly twice as high as those with sleep restriction. Additionally, an increase in mortality and reduced CD4 + , CD8 + , and CD19 + cell numbers were observed in the spleen of female mice with Ehrlich tumors and SD (Maragno‐Correa et al, ). In this study, we observed a reduction in the population of lymphoid progenitors, and even after 24 h of recovery sleep after 72 h of SD, the decrease was maintained (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in the field of sleep have shown the importance of this behavioral state for the homeostasis of the immune system. SD can result in many losses concerning the bidirectional communication of the immune system with the nervous and endocrine systems (Lange et al, , ; Motivala, ; Reis et al, ), reduction in the weight of the lymphoid organs (Zager et al, ) and disruption of the homeostasis of immune cells (Zager et al, ; Guariniello et al, ; Lungato et al, ; Maragno‐Correa et al, ). In this study, it was found that the total populations of B lymphocytes in the spleen tissue were reduced after 72 h of SD (Fig.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sleep Deprivation on Mice Bone Marrow and Spleen B Lymphopoiesis

Lungato

Nogueira‐Pedro

Dias

et al. 2015

Journal Cellular Physiology

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B lymphocytes are immune cells crucial for the maintenance and viability of the humoral response. Sleep is an essential event for the maintenance and integrity of all systems, including the immune system (IS). Thus, sleep deprivation (SD) causes problems in metabolism and homeostasis in many cell systems, including the IS. In this study, our goal was to determine changes in B lymphocytes from the bone marrow (BM) and spleen after SD. Three-month-old male Swiss mice were used. These mice were sleep deprived through the modified multiple platform method for different periods (24, 48, and 72 h), whereas another group was allowed to sleep for 24 h after 72 h of SD (rebound group) and a third group was allowed to sleep normally during the entire experiment. After this, the spleen and BM were collected, and cell analyses were performed. The numbers of B lymphocytes in the BM and spleen were reduced by SD. Additionally, reductions in the percentage of lymphocyte progenitors and their ability to form colonies were observed. Moreover, an increase in the death of B lymphocytes from the BM and spleen was associated with an increase in oxidative stress indicators, such as DCFH-DA, CAT, and mitochondrial SOD. Rebound was not able to reverse most of the alterations elicited by SD. The reduction in B lymphocytes and their progenitors by cell death, with a concomitant increase in oxidative stress, showed that SD promoted a failure in B lymphopoiesis.

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“…Patients in the ICU also spend more time in non‐rapid eye movement sleep stages N1 and N2, which are thought to be less restorative than rapid eye movement or N3 sleep . While a direct correlation between sleep deprivation and mortality in humans has not been established, a mouse model of sleep deprivation has demonstrated increased mortality . Sleep deprivation may lead to a decrease in immune and neurocognitive function, increase in the “fight‐or‐flight” response, and decreased quality of life .…”

Section: Introductionmentioning

confidence: 99%

Survey of clinical pharmacist perceptions and practices in promoting sleep in intensive care unit patients

Heavner

Nguyen

Knauert

et al. 2018

J Am Coll Clin Pharm

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Objectives Sleep deprivation is associated with significant patient morbidity in the intensive care unit (ICU) and must be addressed through a systematic, interdisciplinary approach. The objectives of this study were to describe pharmacists' perceptions and practices regarding sleep in the ICU. We also assessed the prevalence and characteristics of systematic processes to promote sleep in ICU patients. Methods We administered an international, cross‐sectional survey to 1723 pharmacists via a member distribution list through the American College of Clinical Pharmacy Critical Care Practice and Research Network. The survey included questions about pharmacists' demographics, practice sites, and individual and site‐specific perceptions of sleep promotion practices. Results Two hundred fifty‐five (15%) pharmacists initiated the survey and 195 were completed and included for analysis. Respondents most commonly had less than 5 years of experience in ICU practice, completed a Critical Care Pharmacy Residency, and worked in a Medical or Surgical ICU. All participants responded that the assessment of sleep quality is important in the ICU. Most respondents reported that they recommend both non‐pharmacological (81%) and pharmacological (93%) interventions to optimize sleep in their ICU patients. Pharmacists reported most commonly recommending to adjust non‐sleep‐related medications to avoid nighttime administration (41.4%) and initiating melatonin receptor agonists (33.7%). A low number of respondents (9%) reported the presence of a sleep protocol in their ICU. Within this subset, 59% reported that less than half of their ICU patients actually receive the protocol and 41% indicated low protocol compliance. Conclusions Critical care pharmacists value sleep, and most recommend interventions to optimize sleep in their patients. However, sleep protocols in ICUs are uncommon, and overall protocol use and compliance are perceived to be low. Pharmacists can improve protocol use and compliance and potentially impact sleep, delirium incidence, or other ICU patient outcomes. This impact should be evaluated in future studies.

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Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Cited by 22 publications

References 37 publications

Chronic Sleep Restriction Impairs the Antitumor Immune Response in Mice

Chronic Sleep Restriction Impairs the Antitumor Immune Response in Mice

Effects of Sleep Deprivation on Mice Bone Marrow and Spleen B Lymphopoiesis

Survey of clinical pharmacist perceptions and practices in promoting sleep in intensive care unit patients

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