Effects of polymethylmethacrylate nanoplastics on Dicentrarchus labrax

Brandts, I.; Teles, Mariana; Tvarijonaviciute, Asta; Pereira, Maria de Lourdes; Martins, Manuel A.; Tort, L.; Oliveira, Miguel

doi:10.1016/j.ygeno.2018.10.006

Cited by 142 publications

(50 citation statements)

References 37 publications

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“…Previous studies showed that nanoplastic particles are found in the aquatic environment (da Costa et al 2016;Mattsson et al 2018). As such the adverse effects of these nanoparticles on the molecular and biochemical biomarkers were observed on marine fish (Dicentrarchus labrax) (Brandts et al 2018a) and mussel (Mytilus galloprovincialis) (Brandts et al 2018b). Further studies are required to investigate the presence of nanoplastics in commercial fish meals.…”

Section: Discussionmentioning

confidence: 99%

Abundance and properties of microplastics found in commercial fish meal and cultured common carp (Cyprinus carpio)

Hanachi

Karbalaei

Walker

et al. 2019

Environ Sci Pollut Res

104

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Microplastics (MPs) are environmental contaminants that are of increasing global concern. This study investigated presence of MPs in four varieties of marine derived commercial fish meal, followed by identification of their polymer composition using Fourier-Transform Infrared (FTIR) spectroscopy. Exposure experiments were conducted on cultured common carp (Cyprinus carpio) by feeding four varieties of commercially available fish meal to determine relationships between abundance and properties of MPs found both in meal and those transferred to cultured common carp. Mean particle sizes were 452±161 μm (±SD). Fragments were the predominant shape of MP found in fish meal (67%) and C. carpio gastrointestinal tract and gills (65%), and polypropylene and polystyrene were the most present plastic polymers found in fish meal (45% and 24%, respectively) and C. carpio (37% and 33%, respectively). Positive relationships were found between MP levels in fish meal and C. carpio. This study highlights that marine derived fish meal may be a source of MPs which can be transferred to cultured fish, thus posing a concern for aquaculture.

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Section: Discussionmentioning

confidence: 99%

Abundance and properties of microplastics found in commercial fish meal and cultured common carp (Cyprinus carpio)

Hanachi

Karbalaei

Walker

et al. 2019

Environ Sci Pollut Res

104

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“…In vitro neutrophil function assays showed dose-dependent increases in myeloperoxidase activity and neutrophil extracellular trap release in fathead minnows Pimephales promelas exposed to PS nanoparticles (41 nm, 0.025 to 0.2 μg/μL) [111]. Acute exposure to PMMA nanoparticles (45 nm, 0.02 and 0.2 mg/L, for 96 h) diminished the level of oxidative stress in the plasma [112].…”

Section: In Vivo Immunotoxicity Of Nano-and Microplastics In Vertebratesmentioning

confidence: 96%

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

2020

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Background Together with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due to food processes and packaging. Objective The present review aimed at providing a comprehensive overview of current knowledge regarding the effects of nano- and microplastics on intestinal homeostasis. Methods We conducted a literature search focused on the in vivo effects of nano- and microplastics on gut epithelium and microbiota, as well as on immune response. Results Numerous animal studies have shown that exposure to nano- and microplastics leads to impairments in oxidative and inflammatory intestinal balance, and disruption of the gut’s epithelial permeability. Other notable effects of nano- and microplastic exposure include dysbiosis (changes in the gut microbiota) and immune cell toxicity. Moreover, microplastics contain additives, adsorb contaminants, and may promote the growth of bacterial pathogens on their surfaces: they are potential carriers of intestinal toxicants and pathogens that can potentially lead to further adverse effects. Conclusion Despite the scarcity of reports directly relevant to human, this review brings together a growing body of evidence showing that nano- and microplastic exposure disturbs the gut microbiota and critical intestinal functions. Such effects may promote the development of chronic immune disorders. Further investigation of this threat to human health is warranted.

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“…PS microplastics also increased the acetylcholinesterase (AChE) activity and the related neurotransmitters such as threonine, aspartate, and taurine in a mouse model [122]. In addition, microplastics and nanoplastics elicit immunological responses [115,123,124], alter gene expression [88,103,113,114,125] and induce genotoxicity [113,126]. In kidney cells, VC stimulates the expression of fibrosis-related proteins, such as CTGF, PAI-1, and collagen 1, and autophagy-related proteins, such as Beclin 1 and LC3-II [127].…”

Section: Molecular and Cellular Mechanisms Of Plastic Micromaterials Amentioning

confidence: 99%

Potent Impact of Plastic Nanomaterials and Micromaterials on the Food Chain and Human Health

Wang

Lee

Chiu

et al. 2020

IJMS

107

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Plastic products are inexpensive, convenient, and are have many applications in daily life. We overuse plastic-related products and ineffectively recycle plastic that is difficult to degrade. Plastic debris can be fragmented into smaller pieces by many physical and chemical processes. Plastic debris that is fragmented into microplastics or nanoplastics has unclear effects on organismal systems. Recently, this debris was shown to affect biota and to be gradually spreading through the food chain. In addition, studies have indicated that workers in plastic-related industries develop many kinds of cancer because of chronic exposure to high levels of airborne microplastics. Microplastics and nanoplastics are everywhere now, contaminating our water, air, and food chain. In this review, we introduce a classification of plastic polymers, define microplastics and nanoplastics, identify plastics that contaminate food, describe the damage and diseases caused by microplastics and nanoplastics, and the molecular and cellular mechanisms of this damage and disease as well as solutions for their amelioration. Thus, we expect to contribute to the understanding of the effects of microplastics and nanoplastics on cellular and molecular mechanisms and the ways that the uptake of microplastics and nanoplastics are potentially dangerous to our biota. After understanding the issues, we can focus on how to handle the problems caused by plastic overuse.

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Effects of polymethylmethacrylate nanoplastics on Dicentrarchus labrax

Cited by 142 publications

References 37 publications

Abundance and properties of microplastics found in commercial fish meal and cultured common carp (Cyprinus carpio)

Abundance and properties of microplastics found in commercial fish meal and cultured common carp (Cyprinus carpio)

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Potent Impact of Plastic Nanomaterials and Micromaterials on the Food Chain and Human Health

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