Effects of polymer addition on the rheology of o/w microemulsions

Lapasin, Romano; Grassi, Mario; Coceani, N.

doi:10.1007/s003970000151

Cited by 63 publications

(41 citation statements)

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“…Lapasin et al reported that xanthan gum that is soluble in water (aqueous phase) would form a gel network in the continuous phase. 40 This formed network keeps the water molecules from easily sliding from each other, providing a thicker feeling and viscosity to the nanoemulsion. The higher the water content, the more thickening agent was required in forming the gel network.…”

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confidence: 99%

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Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action

Sh¹,

Basri²,

HR³

et al. 2017

IJN

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confidence: 99%

“…The Corneometer is an instrument that is sensitive to water with a high dielectric constant. 40 Results from the Corneometer represent the skin's water capacitance, which reflects the skin-moisturizing property. As for psoriasis patients, having moisturized skin is one of the main strategies in dealing with itchy skin.…”

mentioning

confidence: 99%

Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action

Sh¹,

Basri²,

HR³

et al. 2017

IJN

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“…Gellan gum and xanthan gum are very soluble in water, which lead to the formation of the gel network in a continuous phase in the nanoemulsion even though the gel network increased the viscosity of nanoemulsions. 17 The polydispersity of the T802 formulation was increased from 0.093 to 0.199, 0.203, and 0.332 after the nanoemulsions were modif ied with gellan gum, carrageenan, and xanthan gum, respectively. A high polydispersity system was observed when carrageenan and xanthan gum were used.…”

Section: Resultsmentioning

confidence: 99%

Modification of palm kernel oil esters nanoemulsions with hydrocolloid gum for enhanced topical delivery of ibuprofen

Salim¹,

Basri²,

Rahman³

et al. 2012

IJN

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Introduction: During recent years, there has been growing interest in the use of nanoemulsion as a drug-carrier system for topical delivery. A nanoemulsion is a transparent mixture of oil, surfactant and water with a very low viscosity, usually the product of its high water content. The present study investigated the modification of nanoemulsions with different hydrocolloid gums, to enhanced drug delivery of ibuprofen. The in vitro characterization of the initial and modified nanoemulsions was also studied. Methods: A palm kernel oil esters nanoemulsion was modified with different hydrocolloid gums for the topical delivery of ibuprofen. Three different hydrocolloids (gellan gum, xanthan gum, and carrageenan) were selected for use. Ternary phase diagrams were constructed using palm kernel oil esters as the oil, Tween 80 as the surfactant, and water. Nanoemulsions were prepared by phase inversion composition, and were gradually mixed with the freshly prepared hydrocolloids. The initial nanoemulsion and modified nanoemulsions were characterized. The abilities of the nanoemulsions to deliver ibuprofen were assessed in vitro, using a Franz diffusion cell fitted with rat skin. Results: No significant changes were observed in droplet size (∼16-20 nm) but a significant difference in polydispersity indexes were observed before and after the modification of nanoemulsions using gellan gum, carrageenan, and xanthan gum. The zeta potentials of the initial nanoemulsions (-11.0 mV) increased to -19.6 mV, -13.9 mV, and -41.9 mV, respectively. The abilities of both the initial nanoemulsion (T802) and the modified nanoemulsion to deliver ibuprofen through the skin were evaluated in vitro, using Franz diffusion cells fitted with rat skin. The in vitro permeation data showed that the modified nanoemulsion (Kp value of 55.4 × 10 -3 cm ⋅ h -1 ) increased the permeability of ibuprofen 4.40 times over T802 (Kp value of 12.6 × 10 -3 cm ⋅ h -1 ) (P , 0.05). Conclusion:The modified nanoemulsion may be a promising vehicle to enhance the permeation of ibuprofen for topical delivery.

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“…For example, o/w and w/o microemulsions show Newtonian behavior over a wide range of shears, while the bicontinuous phase may undergo breakage upon medium shear forces, leading to thinning [3]. Although the effect of the molecular structure of emulsions has a large impact on the behavior of microemulsions [20], the characterization techniques are generally the same as their macroscopic counterparts [21,22].…”

Section: Rheologymentioning

confidence: 99%