Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action

Sh, Musa; Basri, Mahiran; HR, Fard Masoumi; Shamsudin, Norashikin; Salim, Norazlinaliza

doi:10.2147/ijn.s125302

Cited by 61 publications

(25 citation statements)

References 42 publications

(47 reference statements)

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“…It meant that there was only a 0.01 % chance that a "model F-value" this large could occur due to noise. A value of "probability > F" being less than 0.05 implied that the model terms were significant [18]. F-value and p-value played a role in determining the significance of each coefficient.…”

Section: Resultsmentioning

confidence: 99%

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Kong¹,

Salim²,

Masoumi³

et al. 2018

Asian J. Chem.

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Optimization of hydrocortisone-loaded nanoemulsion formulation was achieved by low energy emulsification method. D-optimal mixture design was used with the variables parameters of Tween-20, lipoid S75, palm kernel oil ester (PKOE) and deionized water towards a response (viscosity). Hydrocortisone, ethanol and phenonip were kept constant (1.0, 24 and 0.5 wt. %). The mixing rate and time were kept constant at 400 rpm and 4 h, respectively. The optimum formulation conditions were successfully predicted. From the results obtained, it shows that the higher the concentration of palm kernel oil ester, the less the viscosity of the nanoemulsion. The optimized formulation showed good stability with the viscosity of 2.85 Pa.s. The particle size, polydispersity index and zeta potential of the optimized nanoemulsion gave a result of 172.56 nm, 0.184 and-50.03 mV, respectively. The results are in agreement with the TEM micrograph. The viscosity of the optimized nanoemulsion decreased with increased shear rate, showing a shear thinning behaviour (pseudoplastic) suitable for pharmaceutical application.

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Section: Resultsmentioning

confidence: 99%

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Kong¹,

Salim²,

Masoumi³

et al. 2018

Asian J. Chem.

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“…Thus, this would provide a thicker structure and viscosity to the nanoemulsion. 20 The more the xanthan gum concentration along with higher amount of deionized water, the more viscous the aqueous phase. Despite that, a low amount of deionized water with a higher concentration of xanthan gum would give rise to a…”

Section: D-optimal Analysismentioning

confidence: 99%

“…Thus, the increase in droplet size over time was not created by coalescence. 20 Ostwald ripening occurs when particles of the discontinuous phase diffuse from small to larger droplet sizes through the continuous phase (water) of the nanoemulsion system. 33 The stability of the nanoemulsion can be investigated by plotting r 3 vs storage time for determining the rate of Ostwald ripening.…”

Section: Physicochemical Characterization Of Optimized Kmo Nanoemulsionmentioning

confidence: 99%

Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment

Azhar

Ashari

Salim

2018

IJN

Self Cite

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IntroductionKojic monooleate (KMO) is an ester derived from a fungal metabolite of kojic acid with monounsaturated fatty acid, oleic acid, which contains tyrosinase inhibitor to treat skin disorders such as hyperpigmentation. In this study, KMO was formulated in an oil-in-water nanoemulsion as a carrier for better penetration into the skin.MethodsThe nanoemulsion was prepared by using high and low energy emulsification technique. D-optimal mixture experimental design was generated as a tool for optimizing the composition of nanoemulsions suitable for topical delivery systems. Effects of formulation variables including KMO (2.0%–10.0% w/w), mixture of castor oil (CO):lemon essential oil (LO; 9:1) (1.0%–5.0% w/w), Tween 80 (1.0%–4.0% w/w), xanthan gum (0.5%–1.5% w/w), and deionized water (78.8%–94.8% w/w), on droplet size as a response were determined.ResultsAnalysis of variance showed that the fitness of the quadratic polynomial fits the experimental data with F-value (2,479.87), a low P-value (P<0.0001), and a nonsignificant lack of fit. The optimized formulation of KMO-enriched nanoemulsion with desirable criteria was KMO (10.0% w/w), Tween 80 (3.19% w/w), CO:LO (3.74% w/w), xanthan gum (0.70% w/w), and deionized water (81.68% w/w). This optimum formulation showed good agreement between the actual droplet size (110.01 nm) and the predicted droplet size (111.73 nm) with a residual standard error <2.0%. The optimized formulation with pH values (6.28) showed high conductivity (1,492.00 µScm−1) and remained stable under accelerated stability study during storage at 4°C, 25°C, and 45°C for 90 days, centrifugal force as well as freeze–thaw cycles. Rheology measurement justified that the optimized formulation was more elastic (shear thinning and pseudo-plastic properties) rather than demonstrating viscous characteristics. In vitro cytotoxicity of the optimized KMO formulation and KMO oil showed that IC50 (50% inhibition of cell viability) value was >100 µg/mL.ConclusionThe survival rate of 3T3 cell on KMO formulation (54.76%) was found to be higher compared to KMO oil (53.37%) without any toxicity sign. This proved that the KMO formulation was less toxic and can be applied for cosmeceutical applications.

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“…1 Several attempts with modified approaches are under way for developing Cyclosporine loaded emulsified droplets for delivery to target organs. [2][3][4][5] Cyclosporine delivery using nanosized droplets have been found to be a better option as compared to microemulsions. Microemulsions are less thermodynamically stable, having higher tendency of particle coalescence.…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine A Loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil

Bhargava¹,

Madhav²

2020

IJPER

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Title: Cyclosporine A loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil. Aim: Nanoemulsions formulation development is an upcoming approach to deliver peptides. The approach reduces challenges during peptide delivery by many folds. Nanoemulsions contains drugs encapsulated or solubilized in an oily phase, with water as continuous phase. In our research, nanoemulsion have been developed for Cyclosporine a using fractions of Sesame oil as encapsulating agent. Methods: The comparison between oil fractions (SOC; SOAM) and Sesame oil have been well proved through Spectral studies like FT-IR, GC-MS and rheology studies. Nanoemulsions have been developed using a modified solvent-evaporation method. FT-IR of oil fraction also shows absence of peaks showing peptide fragments, indicating its encapsulation inside oil fraction. Conclusion: The zeta potential of our selected formulation FSC2 among FSC1-FSC12 has been found to be -15 mV, while its polydispersity is 0.325. The in vitro studies clearly reveals first order release mechanism as best fit model for selected formulation. The r 2 for selected formulation has been identified to be 0.99. The t80 of FSC2 has been found to be 6.5 Hrs. The TEM Studies of formulation reveal spherical appearance of particles with average particle size between 50-220 nm.

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Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action

Cited by 61 publications

References 42 publications

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment

Cyclosporine A Loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil

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