Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils

Synthesis, Nematicidal and Antimicrobial Activity of 3-(5-3-Methyl-5-[(3-methyl-7-5-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-1,3,4-thiadiazol-2-ylbenzo[<i>b</i>]furan-5-yl)methyl]benzo[<i>b</i>]furan-7-yl-1,3,4-thiadiazol-2-yl)-2-(aryl)-1,3-thiazolan-4-one

“…Thiazolidine-4-one derivatives are known to exhibit diverse bioactivities such as anti-convulsant, 17) antidiarrheal, 18) antiplatelet activating factor, [19][20][21] anti-histaminic, 22,23) antimicrobial, 24,25) anti-diabetic, 26) cyclooxygenase (COX) inhibitory, 27) Ca 2ϩ -channel blocker, 28) platelet activating factor (PAF) antagonist, 29) cardioprotective, 30) anti-ischemic, 31) anticancer, 32) tumour necrosis factor-a antagonist 33) and nematicidal activities. 34) Nematodes are tiny worms, some of them are plant parasites and can play an important role in the predisposition of the host plant to the invasion by secondary pathogens.…”

Synthesis and antimicrobial activity of novel 2‐(aryl)‐3‐[5‐(2‐oxo‐2H‐3‐chromenyl)‐1,3‐oxazol‐2‐yl]‐1,3‐thiazolan‐4‐ones

“…Coumarins are a class of compounds with biological activity, such as analgesics [1, 2], anticoagulant [3], specific inhibitors of α‐chymotripsin [4], human leukocyte elastase [5], diuretics [6], platelet aggregation [7], anticancer [8], inhibitor of HIV‐1 protease [9], and antibacterial [10, 11]. Further, there is a considerable interest in the chemistry of thiazolidine‐4‐one ring system, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities [12–14], such as anticonvulsant [15], antidiarrheal [16], antiplatelet activating factor [17–19], antihistaminic [20, 21], antimicrobial [22, 23], antidiabetic, [24] cyclooxygenase (COX) inhibitory [25], Ca 2+ ‐channel blocker [26], platelet activating factor (PAF) antagonist [27], cardioprotective [28], anti‐ischemic [29], anticancer [30], tumor necrosis factor‐α antagonist [31], and nematicidal [32]. Therefore, the simple and efficient method for rapid synthesis of thiazolidine‐4‐ones would be greatly advantageous and warrants for further investigation in drug discovery.…”

Synthesis, Nematicidal and Antimicrobial Properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2<i>H</i>-pyrazolo[3,4-<i>d</i>]thiazol-5-yl]phenyl]methanes

“…[6][7][8] Thiazolidin-4-one ring also occurs in nature; thus actithiazic acid [(Ϫ)2-(5-carboxypentyl)thiazolidin-4-one] isolated from Streptomyces strains exhibits highly specific in vitro activity against Mycobacterium tuberculosis. 9,10) Thiazolidin-4-one derivatives are known to exhibit diverse bioactivities such as anticonvulsant, 11) antidiarrheal, 12) anti-platelet activating factor, [13][14][15] antihistaminic, 16,17) antimicrobial, 18,19) antidiabetic, 20) cyclooxygenase (COX) inhibitory, 21) Ca 2ϩ channel blocker, 22) platelet activating factor (PAF) antagonist, 23) cardioprotective, 24) anti-ischemic, 25) anticancer, 26) tumor necrosis factor-a antagonist 27) and nematicidal activities. 28) Pyrazole and their derivatives could be considered as possible antimicrobial agents.…”