Synthesis and antimicrobial activity of novel 2‐(aryl)‐3‐[5‐(2‐oxo‐2H‐3‐chromenyl)‐1,3‐oxazol‐2‐yl]‐1,3‐thiazolan‐4‐ones

Abstract

A series of novel 2-(aryl)-3-[5-(2-oxo-2H-3-chromenyl)-1,3-oxazol-2-yl]-1,3-thiazolan-4-ones 4a-j have been synthesized and assayed for their antibacterial activity against Gram-positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p), Micrococcus luteus (IFC 12708), and Gram-negative bacteria viz. Proteus vulgaris (ATCC 3851), Salmonella typhimurium (ATCC 14028), Escherichia coli (ATCC 25922), and also antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185), and Trichophyton mentagrophytes (IFO 40996). Among the screened compounds, 4d, 4e, 4f, 4g, and 4j exhibited potent inhibitory activity compared with the standard drug at the tested concentrations. The results reveal that, the presence of difluorophenyl in 4f and pipernyl ring in 4j at 2-position of thiazolidine-4-one ring show significant inhibitory activity. The other compounds also showed appreciable activity against the test bacteria and fungi and emerged as potential molecules for further development.

Substituted 3-E-Styryl-2H-chromenes and 3-E-Styryl-2H-thiochromenes: Synthesis, Photophysical Studies, Anticancer Activity, and Exploration to Tricyclic Benzopyran Skeleton

“…Substituted 2 H -chromenes (2 H -1-benzopyran derivatives), 2 H -thiochromenes and their analogues constitute a significant family of scaffolds found in a myriad of physiologically active naturally occurring and artificial molecules . Because of a rich array of functionalities these motifs are acknowledged as expedient building blocks in a wide range of bioactive heterocyclic compounds having anticancer, anti-HIV, anti-inflammatory, antioxidant, antitubercular, antiviral, antitumor, antibacterial/antimicrobial, antidiabetic, anticoagulant, antianaphylatic, diuretic, fungicidal, sex-pheromone and many other activities . Because of their intense photophysical behavior, these compounds have also been applied in diverse fields including laser dyes, organic light emitting devices (OLEDs), optical brighteners, organic scintillators, triplet sensitizer, fluorescence probes and exhibit outstanding photochromic properties .…”