Effects of Phytosterols supplementation on blood glucose, glycosylated hemoglobin (HbA1c) and insulin levels in humans: a systematic review and meta-analysis of randomized controlled trials

Salehi‐Sahlabadi, Ammar; Varkaneh, Hamed Kord; Shahdadian, Farnaz; Ghaedi, Ehsan; Nouri, Mehran; Singh, Ambrish; Farhadnejad, Hossein; Găman, Mihnea‐Alexandru; Hekmatdoost, Azita; Mirmiran, Parvin

doi:10.1007/s40200-020-00526-z

Cited by 26 publications

(19 citation statements)

References 48 publications

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“…Plant stanols, the saturated forms of plant sterols, are also found in some foods, but less abundantly when compared with plant sterols. Beneficial effects of phytosterols on many chronic diseases, such as cardiovascular diseases (Bacchetti et al, 2011; Calpe‐Berdiel et al, 2009; Dash et al, 2021; Hannan et al, 2020; Ros, 2010) and diabetes (Hannan et al, 2020; Salehi‐Sahlabadi et al, 2020), have been reported in several studies. Also, diets rich in phytosterols have been suggested to reduce the risk of cancer (Ramprasath & Awad, 2015; Suttiarporn et al, 2015).…”

Section: Introductionmentioning

confidence: 98%

Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review

Nattagh‐Eshtivani

Barghchi

Pahlavani

et al. 2021

Phytotherapy Research

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Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological properties, including the potential to reduce total and low‐density lipoprotein (LDL) cholesterol levels and thereby decreasing the risk of cardiovascular diseases. Other health‐promoting effects of PSs include anti‐obesity, anti‐diabetic, anti‐microbial, anti‐inflammatory, and immunomodulatory effects. Also, anticancer effects have been strongly suggested, as phytosterol‐rich diets may reduce the risk of cancer by 20%. The aim of this review is to provide a general overview of the available evidence regarding the beneficial physiological and pharmacological activities of PSs, with special emphasis on their therapeutic potential for human health and safety. Also, we will explore the factors that influence the physiologic response to PSs.

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Section: Introductionmentioning

confidence: 98%

Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review

Nattagh‐Eshtivani

Barghchi

Pahlavani

et al. 2021

Phytotherapy Research

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“…Thirteen of these studies were excluded because they included an abstract ( N = 5) or a protocol ( N = 1) only, were not published in English ( N = 1), had inappropriate exposures ( N = 2) or outcomes ( N = 1), or did not provide updated data ( N = 2). As a result, 50 systematic reviews and meta‐analyses were included in the final analysis (Figure 1; Amir Shaghaghi et al, 2013; Askari et al, 2019; Azhdari et al, 2019; Chen et al, 2020; Fatahi et al, 2019; Ghaedi et al, 2019; Ghaedi et al, 2020; Glisic et al, 2018; Gui et al, 2016; Hadi et al, 2018, 2020; Hadi, Pourmasoumi, Mohammadi, et al, 2019; Hadi, Pourmasoumi, Najafgholizadeh, et al, 2019; Hallajzadeh et al, 2020; Hamedifard et al, 2019; Han et al, 2019; Hasani et al, 2019; Hemati et al, 2020; Hernández‐García et al, 2019; Heshmat‐Ghahdarijani et al, 2020; Karimian et al, 2019; Khorshidi et al, 2020; Li et al, 2014, 2015, 2020; Maierean et al, 2017; Mansour‐Ghanaei et al, 2018; Mohammadi, Hadi, et al, 2019; Mohammadi, Ramezani‐Jolfaie, et al, 2019; Ostadmohammadi et al, 2019; Pourmasoumi et al, 2018, 2020; Rahmani et al, 2019; Rahmani et al, 2020; Ricci et al, 2010; Ried, 2016; Rocha et al, 2019; Sahebkar, 2014; Sahebkar, Simental‐Mendía, et al, 2016; Sahebkar, Soranna, et al, 2016; Salehi‐Sahlabadi et al, 2020; Serban et al, 2015; Shekarchizadeh‐Esfahani et al, 2020; Taku et al, 2010; Ursoniu et al, 2018; Zhang et al, 2020; Zhang, Yuan, et al, 2016; Zhang, Liu, et al, 2016; Zhu et al, 2017; Ziaei et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

Hoang

Kim

2021

Phytotherapy Research

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Phytonutrients exert several pharmacological effects on humans. In this study, we performed an umbrella review of the association of phytonutrient supplements (PNSs) with biomarkers of cardiovascular disease. Relevant published systematic reviews and meta‐analyses of clinical trials were identified by searching PubMed, Embase, and Cochrane Library until July 4, 2020. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) for summarized effects and I2 statistics of heterogeneity were extracted from individual studies or reanalyzed using a random‐effects model. Of the 50 included studies, pooled effects of PNSs on blood pressure, lipid profiles, and glycemic control were reported in 16, 25, and 14 articles, respectively. The findings appeared to be highly heterogeneous among individual trials of included systematic reviews and meta‐analyses. Ginger (WMD = −6.36 mmHg, 95% CI = −11.27, −1.46) and Hibiscus sabdariffa (WMD = −7.58 mmHg, 95% CI = −9.69, −5.46) were associated with lowered systolic blood pressure, whereas Aloe vera, Nigella sativa, and spirulina were associated with beneficial effects on both lipid profiles and glycemic control. In summary, this umbrella review has provided up‐to‐date evidence for the effect of PNSs on biomarkers related to hypertension, dyslipidemia, and diabetes. The results must be interpreted with caution due to potential heterogeneity.

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“… 36 Another systematic review and meta-analysis of randomized controlled trials found that phytosterols supplementation at 1–2 g/day could effectively lower fasting blood sugar and glycosylated hemoglobin. 37 Additionally, green tea supplementation associated with a balanced and healthy diet and regular physical exercise has been suggested to improve anthropometric indices in obese subjects. 38 Lastly, a systematic review and meta-analysis of randomized controlled trials found that probiotic/symbiotic supplementation can significantly increase serum TAC, glutathione and NO, as well as reduce MDA levels in adults.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mamede¹,

Lima²,

Silva³

et al. 2021

DMSO

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Aim The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D. Methods Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention. Results Anthropometric variables (waist circumference, waist–hip ratio, waist–height ratio and body mass index) were similar between groups ( p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde ( p =0.021) and C-reactive protein ( p =0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p =0.035), alanine aminotransferase (ALT, p <0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups. Conclusion In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.

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Effects of Phytosterols supplementation on blood glucose, glycosylated hemoglobin (HbA1c) and insulin levels in humans: a systematic review and meta-analysis of randomized controlled trials

Cited by 26 publications

References 48 publications

Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review

Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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