Effects of Phyllanthus urinaria extract on HepG2 cell viability and oxidative phosphorylation by isolated rat liver mitochondria

Self-assembly of glycinin nanoparticles for delivery of phenolic compounds from Phyllanthus urinaria

“…This 28 demonstrates that the effect of pH (X 1 ) and glycinin concentration (X 2 ) on encapsulation 29 efficiency is significant and is in good agreement with the results in contour plots in Fig. 2 mean that the interaction between the two variables is not significant, 1 which also agrees with the results in Table 4. From Fig.…”

“…P. urinaria has been used as a traditional medicine for 2 the treatment of some diseases including diarrhea, dysentery, hepatitis, edema, infantile 3 malnutrition, acute conjunctivitis, aphthae and antibiotic resistant pyogenic infections 4 4 because it has many biological and pharmacological activities in vitro and in vivo, such as 5 antiviral 5,6 , hepatoprotective anti-inflammatory 7,8 , hypoglycemic and hypocholesterolemic 9 , 6 antioxidant 10,11 , anti-allodynic and anti-oedematogenic 12 , and antibacterial 13 properties. The 7 anticancer effect of P. urinaria has been reported in some academic literatures 2,6,14-17 , and in 8 recent years there is increasing interest to understand and develop alternative agents from P. 9 urinaria compounds for the treatment of hepatitis B virus and liver cancer 1,[18][19][20][21][22] . It is believed 10 that the phenolic compounds from P. urinaria are one of the main effective substances for the 11 treatment of hepatitis B virus and liver cancer [23][24][25][26] .…”

“…In recent years, proteins and peptides have gained great interest in delivering 29 drugs and bioactive molecules 36-40 . Soy protein is an abundant, renewable, and inexpensive 30 natural protein, which has gained considerable attention for its potential role in improving risk 1 factors for cardiovascular disease 39 . Glycinin is one of the two major globulins of soy protein, 2 and is sensitive to the pH of solution.…”

Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways

“…Phyllanthus can now be found in almost every tropical country because of its wide medicinal usage and lack of toxicity (Paranjape, 2001). P. urinaria is widely used as anti-inflammatory, antiviral, antibacterial and antihepatotoxic medicines (Thyagarajan et al, 1988;Cheng et al, 2011;Chudapongse et al, 2010;Hau et al, 2009;Lai et al, 2008). All parts of the plant may be employed therapeutically (Xu et al, 2007).…”

Phyllanthus urinariaInduces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria-Mediated Pathways

“…Our previous study demonstrated that the aqueous extract of P. urinaria could induce apoptosis in human cancer cells derived from several different origins [12]. Chudapongse et al reported that P. urinaria could inhibit Hep G2 cell proliferation by acting as an uncoupler and inhibitor of mitochondrial-oxidative phosphorylation [13]. Meanwhile, the water extract of P. urinaria exhibited an anticancer effect in an in vivo study not only through apoptosis, but also antiangiogenesis pathways in C57BL/6J mice with implanted Lewis lung carcinoma cells [14].…”