Effects of phototherapy on Cytokines′ levels and white blood cells in term neonate with hyperbilirubinemia

Jahanshahifard, Sedigheh; Ahmadpour-Kacho, Mousa; Pasha, Yadollah Zahed

doi:10.4103/2249-4847.101696

Cited by 11 publications

(9 citation statements)

References 13 publications

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“…Serum TNF-α level significantly increased after 72 hours of exposure to phototherapy and this change was statistically significant (P<0.001), indicating the strong effect of phototherapy on TNF-α serum level. These results are in agreement with that of Jahan et al [13] who stated that exposure to phototherapy in the treatment of neonates with hyperbilirubinemia can affect the synthesis and release of cytokines from the peripheral immune system, as it increases serum TNF-α. In addition, these results are also in agreement with that of Maisels and McDonagh [14] who stated that an imbalance in the production of different cytokines induces immune system failure.…”

Section: Discussionsupporting

confidence: 93%

The effect of phototherapy on serum level of tumor necrosis factor alpha in neonates in Damietta governorate

Neam

Zannoun

2019

International Journal of Medical Arts

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Background: Jaundice is one of the most common conditions confronting neonatologists daily. Phototherapy is generally regarded as a safe method for treating hyperbilirubinemia, but it may also lead to undesired effects, one of these effects that it can affect the function of the immune system of the newborn. Aim of the work: The aim of the work was to study the effect of phototherapy on the serum level of tumor necrosis factor-alpha [TNF-α] in neonates. Patients and methods: A total of 35 cases of term neonates with Neonatal Jaundice and indirect hyperbilirubinemia high to the level that need phototherapy for 72hrs or more according to the guidelines of the American Academy of Pediatrics were included in this study, and 15 healthy matched newborns were selected as controls. TNF-α was measured before exposure and after 72 hours phototherapy and from control group at the time of examination. Serum levels of TNF alpha were measured using enzyme linked immunosorbent assay kits. Results: The results showed that there was no statistically significant in patient group before phototherapy in comparison to control group as regards TNF-α, patient demographics or laboratory data. On the other side, serum TNF-α levels significantly increased after exposure to phototherapy for 72 hours when compared to values before phototherapy (151.49±61.97 vs 61.36±31.96 respectively), indicating the influence of phototherapy on serum level of TNF-α. Conclusion: The results demonstrated increased serum TNF-α level after 72 hours may affect the immune system in neonates.

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Section: Discussionsupporting

confidence: 93%

The effect of phototherapy on serum level of tumor necrosis factor alpha in neonates in Damietta governorate

Neam

Zannoun

2019

International Journal of Medical Arts

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“…Regarding leukocyte counts, Zarkesh et al 20 and Jahanshahifard et al 39 showed an increase in circulating leukocytes after phototherapy in icteric neonates, and Mrkaić et al 40 showed an increase in the total number of polymorphonuclear leukocytes, lymphocytes, and monocytes; however, these findings were temporary. The study by Mrkaić et al evaluated the effects of phototherapy on the immune system of newborn without signs of asphyxia or infection, which may explain this only temporary response, not being possible establish the consequences of phototherapy in the presence of baseline disease.…”

Section: Hematologic Alterationsmentioning

confidence: 99%

Side Effects of Phototherapy on Neonates

2018

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Phototherapy in neonates for treatment of pathological jaundice is an effective therapeutic tool that is widely used in neonatal units. Over the past years, a greater concern has emerged about the effects on the immune and inflammatory system and its potential genotoxic and side effects, especially the late ones, possibly associated with childhood diseases, showing that this treatment is not as harmless as previously believed. Numerous studies assessing these possible adverse effects of phototherapy on neonates have been published over the past years. Through this review, we seek to analyze what we know about the side effects of phototherapy in the neonatal period. The main causes of jaundice, phototherapy techniques, acute and late side effects, and effects on the immune and inflammatory system were reviewed. It was concluded that phototherapy is not a treatment free of side effects and further studies need to be conducted to elucidate its harmful effects on neonates.

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“…Saber et al found a increase in TNF‐alfa levels, whereas leukocyte counts did not differ. Jahanshahifard et al did not find differences in the levels of TNF‐alfa, IL‐1, or IL‐6 after phototherapy and found an increase in leukocyte count. Kurt et al observed a increase in IL‐8, IL‐1beta, and TNF‐alfa levels and a decrease in the percentage of T‐cell lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Phototherapy side effects may occur in short or long term, a greater concern has emerged in recent years about the effects on the immune and inflammatory system and its potential genotoxicity and other side effects . Over the last decades, several studies have emerged evaluating the influence of phototherapy on the allergic, immune and inflammatory responses and showing evidence that phototherapy can directly affect the expression and function of cell surface receptors, including adhesion molecules, cytokines, and growth factor receptors . Studies also demonstrate increased DNA damage in leukocytes of hyperbilirubinemic neonates who were submitted to phototherapy .…”

Section: Introductionmentioning

confidence: 99%

Expression of neutrophil surface markers in icteric neonates before and after phototherapy

Faulhaber

Marcondes³

et al. 2018

Cytometry Part B Clinical

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Background Jaundice due to indirect hyperbilirubinemia affects more than 60% of neonates and phototherapy is the treatment for severe types. There are no previous studies evaluating the effect of phototherapy on the function of neonates neutrophils. The aim of this study was to assess and compare the function of neutrophils by measuring the expression of neutrophils main surface markers in icteric neonates before and after phototherapy. Methods Neonates at a gestational age ≥35 weeks and birth weight ≥2,000 g who met the American Academy of Pediatrics criteria for phototherapy were included. Flow cytometry evaluation of the mean fluorescence intensities of CD10, CD11b, CD11c, CD15, CD16, CD18, CD62L, CD64, and CD66acde was performed before and 24 h after the initiation of phototherapy. Results Twenty‐five neonates at a mean age of 53 h of life were included in the study with a mean bilirubin level of 13.60 ± 2.85 mg/dL. There was no statistical difference in the expression of CD11b, CD15, CD18, CD62L, and CD64 or in the percentage of neutrophils before and after 24 h of phototherapy. There was an increase in the expression of CD10 and CD16 and a decrease in the expression of CD11c and CD66acde after 24 h of phototherapy. Conclusions Newborns submitted to phototherapy had an increase in the expression of CD10 and CD16 and a decreased in the expression of CD11c and CD66acde after 24 h of treatment, which may be related to an anti‐inflammatory effect of phototherapy. © 2018 International Clinical Cytometry Society

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Effects of phototherapy on Cytokines′ levels and white blood cells in term neonate with hyperbilirubinemia

Cited by 11 publications

References 13 publications

The effect of phototherapy on serum level of tumor necrosis factor alpha in neonates in Damietta governorate

The effect of phototherapy on serum level of tumor necrosis factor alpha in neonates in Damietta governorate

Side Effects of Phototherapy on Neonates

Expression of neutrophil surface markers in icteric neonates before and after phototherapy

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