Effects of PCPA and selective REM sleep deprivation on rotorod performance and open-field behavior in the rat

Abstract

The effects of P-chlorophenylalinine (PCPA) administration or of selective REM sleep deprivation (REMD) on open-field behavior and rotorod performance in rats were examined. Baseline performance and behavior were obtained over 10 days, then treatments were administered for 12 days, and recovery was measured over 5 days. Both PCPA and REMD produced shorter emergence latencies in the open field and increased locomotor activity and rearing. The effects of PCP A occurred during the first 6 days after injection, whereas the effects of REMD occurred during the last 6 days of the 12-day treatment period. Although PCPA and REMD produced similar changes in behavior, different mechanisms may have been involved.

PtNPt/MWCNT-PEDOT:PSS-Modified Microelectrode Arrays for the Synchronous Dopamine and Neural Spike Detection in Rat Models of Sleep Deprivation

“…Sleep deprivation model in rats was induced by the chemical reagent method. p -Chlorophenylalanine (PCPA) was used in this study, which is the inhibitor of serotonin (5-HT) synthesis and could induce a long-lasting sleep loss on the animals. , PCPA was suspended evenly in a gum acacia (wt, 0.5%)/physiological saline solution (pH 7.5). The rats were given an intraperitoneal injection of PCPA suspension (300 mg/kg) daily for two consecutive days.…”