The effects of P-chlorophenylalinine (PCPA) administration or of selective REM sleep deprivation (REMD) on open-field behavior and rotorod performance in rats were examined. Baseline performance and behavior were obtained over 10 days, then treatments were administered for 12 days, and recovery was measured over 5 days. Both PCPA and REMD produced shorter emergence latencies in the open field and increased locomotor activity and rearing. The effects of PCP A occurred during the first 6 days after injection, whereas the effects of REMD occurred during the last 6 days of the 12-day treatment period. Although PCPA and REMD produced similar changes in behavior, different mechanisms may have been involved.
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