Effects of Oophorectomy and Hormone Replacement Therapy on the Pulsatility Indices of Hepatic and Renal Arteries

Mihmanlı, İsmail; Mihmanlı, Veli; Kantarcı, Fatih; Albayram, Mehmet Sait; Atakir, Kadir; Cantasdemir, Murat; Akman, Canan

doi:10.7863/jum.2002.21.4.367

Cited by 3 publications

(1 citation statement)

References 21 publications

(19 reference statements)

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“…Studies have reported that estrogen increases the contraction caused by α2-adrenoceptor activation in the presence of clonidine, an α2-adrenoceptor agonist (Tejera et al, 1999). Moreover, Mihmanli et al (2002) reported that in the human renal artery, vascular tone is dependent on estrogen levels. We hypothesize that the effects of 17β-estradiol on renal arterial tone may regulate contraction through Ca 2+ pump activity as shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of contractile activity in the renal artery of ovariectomized rats

Enkhjargal

Hashimoto

Kinoshita

et al. 2008

J. Smooth Muscle Res.

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The incidence of cardiovascular disease is markedly lower in cycling, pre-menopausal women and post-menopausal women receiving estrogen than in men or untreated postmenopausal women. Clinical studies demonstrate a protective role of estrogen in hormone replacement therapy in terms of reducing cardiovascular risk. However, the benefits of hormone replacement therapy in cardiovascular disease remain unclear. We investigated the effects of estrogen on the contractile responses of the renal artery of ovariectomized Wistar rats (OVX) compared to both ovariectomized 17β-estradiol-treated rats (OVXE) and sham-operated (control) rats. Isometric contraction of renal artery was recorded with a strain gauge transducer. The maximum contractile response of the renal artery smooth muscle to KCl (80 mM) in the OVXE group was significantly higher than that in both the control and OVX groups. The phenylephrine (PE) concentration-response curves in all three groups indicated a greater sensitivity at lower concentrations of PE following treatment with 100 µM L-arginine methyl ester (L-NAME). The EC50 values for PE in the three groups were 2 times lower in the presence of L-NAME than those lacking exposure to L-NAME. The EC50 value for PE in the OVX group was ~3 times lower in the presence of L-NAME than in those lacking exposure to L-NAME and 100 nM BMY 7378, an α1D-adrenoceptor antagonist. The rate of relaxation of the PE-induced contraction (T1/2) was significantly reduced in the OVX group relative to both the control and OVXE groups.T1/2 values after treatment with 100 µM L-NAME were slower than those lacking exposure to L-NAME in all groups. Further, the T1/2 value of the OVX group was 2 times greater than that of the control; this change was reversed in the OVXE group. In conclusion, our results suggest that estrogen regulates contraction and relaxation in the renal artery via NO synthase activity and alteration of the Ca 2+ transport systems.

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Section: Discussionmentioning

confidence: 99%

Characteristics of contractile activity in the renal artery of ovariectomized rats

Enkhjargal

Hashimoto

Kinoshita

et al. 2008

J. Smooth Muscle Res.

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Carotid intima-media thickness in surgical menopause: women who received HRT versus who did not

Mihmanlı

Atakir

et al. 2002

Maturitas

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Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen–progestin therapy in hypertensive postmenopausal women

Posadzy-Małaczyńska

Rajpold

Woźnicka-Leśkiewicz

et al. 2019

Current Medical Research and Opinion

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Effects of Oophorectomy and Hormone Replacement Therapy on the Pulsatility Indices of Hepatic and Renal Arteries

Abstract: Hepatic arterial pulsatility indices are not affected in postmenopausal women, but renal artery pulsatility indices rise to some extent in women not receiving hormone replacement therapy.

Cited by 3 publications

References 21 publications

Characteristics of contractile activity in the renal artery of ovariectomized rats

Characteristics of contractile activity in the renal artery of ovariectomized rats

Carotid intima-media thickness in surgical menopause: women who received HRT versus who did not

Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen–progestin therapy in hypertensive postmenopausal women

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