Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen–progestin therapy in hypertensive postmenopausal women

Posadzy-Małaczyńska, Anna; Rajpold, Katarzyna; Woźnicka-Leśkiewicz, Lucyna; Justyna, M

doi:10.1080/03007995.2019.1612656

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…In addition, SUA has been identified as an important determinant of different outcomes in cardiovascular diseases [22]. Menopause may also lead to problems in SUA excretion and thus increased SUA levels [23]. In our study, we found that age was positively correlated with SUA and HUA (r = 0.068, p < 0.001).…”

Section: Association Between Sua and Cvd In Postmenopausal Womensupporting

confidence: 55%

Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women

Guo¹,

Liu²,

Feng³

et al. 2022

Rev. Cardiovasc. Med.

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Background: Serum uric acid (SUA) levels has been considered a possible risk factor for coronary artery disease (CAD) for many years. Since SUA levels are greatly affected by medications, diet, and metabolism, the association between SUA and CAD has been controversial for centuries. While, the state of hyperuricemia (HUA) has been proven to have a negative impact on CAD in previous studies, there are still few clinical and epidemiological studies of HUA in CAD. In particular, evidence of this association is limited in postmenopausal women. This study explored the influence of SUA levels and HUA on CAD in this demographic group. Methods: In total, 5435 postmenopausal women were allocated to either a non-CAD group (n = 2021) or a CAD group (n = 3414). Regression analyses, including generalized linear models (GLM), correlation analysis, comparison between stratified groups, and analysis by use of diuretics were carried out on data obtained in this study. Results: SUA and HUA were found to associate significantly with CAD by univariate logistic regression analysis. In addition, GLM showed nonlinear response of CAD probability with increasing level of SUA. In multivariate analysis, we found that SUA and HUA were independently related to CAD. Correlation analysis showed that SUA and HUA both correlated positively with CAD (p < 0.001). By comparing the stratified age groups, we found that the differences among the age groups were significant (p < 0.05). Conclusions: SUA and HUA were shown to be independently associated with CAD among postmenopausal women.

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Section: Association Between Sua and Cvd In Postmenopausal Womensupporting

confidence: 55%

Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women

Guo¹,

Liu²,

Feng³

et al. 2022

Rev. Cardiovasc. Med.

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“…Previous research that explored the relationship between sleep duration and hyperuricemia also produced inconsistent findings between men and women ( 20 , 51 ). Men and women have varied sex hormone levels and types, and their bodies react differently to them ( 52 ). These factors may lead to gender variations in serum urate excretion.…”

Section: Discussionmentioning

confidence: 99%

Association between nocturnal sleep duration and the risk of hyperuricemia among Chinese government employees: A cross-sectional study

Ouyang

et al. 2022

Front. Public Health

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ObjectivesEvidence has shown that nocturnal sleep duration is associated with the risk of hyperuricemia, yet the findings are inconsistent. Thus, we aimed at exploring the association between nocturnal sleep duration and the risk of hyperuricemia in Chinese government employees.MethodsA total of 10,321 government employees aged 20–60 years were collected from the Cohort Study on Chronic Diseases among Government Employees in Hunan Province, China. Sleep duration was self-reported. And serum uric acid levels >420 μmol/L in men and >360 μmol/L in women were considered hyperuricemia. The association between nocturnal sleep duration and hyperuricemia risk was examined utilizing multivariate logistic regression models. To further examine the connection between nocturnal sleep duration and serum uric acid levels, multiple linear regression analyses were utilized.ResultsThe prevalence of hyperuricemia was 17.2%. The results of logistic regression demonstrated that, in contrast to participants whose sleep duration was 7–8 h, those who slept for <7 h had an elevated risk of hyperuricemia (OR = 1.343, 95%CI: 1.126, 1.601). Further stratified analysis revealed that this association was still observed in those without obesity (OR = 1.365; 95%CI: 1.127, 1.655), hypertension (OR = 1.290, 95%CI: 1.054, 1.578), or diabetes mellitus (OR = 1.361, 95%CI: 1.136, 1.631). Multiple linear regression showed that shorter sleep duration (< 7 h) was positively correlated with serum uric acid levels. In comparison to individuals who slept for 7–8 h, those with sleep duration of fewer than 7 h had serum uric acid levels that were 7.231 μmol/L (95% CI: 2.875, 11.588) higher.ConclusionShort nocturnal sleep duration (< 7 h) was associated with a higher risk of hyperuricemia, especially in participants without obesity, hypertension, or diabetes mellitus. Besides, short nocturnal sleep duration was related to greater uric acid levels.

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“…We deduced that the high HUA prevalence in young men was mainly correlated to a high purine diet, while in elderly women it was primarily associated with metabolism and hormone levels. Moreover, the prevalence of HUA was significantly increased in women over 50 years of age, highly likely due to declining oestrogen levels and resultant decreased uric acid excretion 34…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hyperuricaemia among adults from Ningxia Hui Autonomous Region, China: a cross-sectional study

Shi,

Liu,

Wang

et al. 2023

BMJ Open

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ObjectiveThis study aimed to estimate the prevalence of hyperuricaemia (HUA) and investigate its risk factors in the general adult population of Ningxia Hui Autonomous Region (NHAR), China.DesignCross-sectional study.SettingSurvey of cardiovascular disorders and their related risk factors in NHAR, China.Participants10 803 permanent residents aged 18 and older.Main outcome measuresHUA was defined as serum uric acid levels >420 µmol/L for men and >360 µmol/L for women.ResultsThe overall prevalence of HUA in NHAR adults was 19.81% (95% CI 19.06 to 20.57), with prevalence values of 24.91% (95% CI 23.70 to 26.14) in men and 15.58% (95% CI 14.66 to 16.53, p<0.001) in women. The prevalence of HUA was higher in urban residents than in rural residents (23.26% vs 17.02%, p<0.001). HUA prevalence was relatively high in individuals younger than 30 years for both men and women, then decreased with age, and began to increase at the age of 40 for women and 60 for men. Higher level of education, being overweight or obese, alcohol consumption, hypertension, diabetes, higher triglycerides, higher total cholesterol and poorer renal function were associated with an increased risk of HUA.ConclusionsHUA prevalence is high among adults in NHAR. Young adults under 30 years and women over 50 years were identified as populations at high risk for HUA. Further attention ought to be placed to promoting healthy diets and implementing early interventions to manage dyslipidaemia, obesity and blood glucose level, as well as advocating for moderation of alcohol consumption.

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Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen–progestin therapy in hypertensive postmenopausal women

Cited by 6 publications

References 37 publications

Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women

Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women

Association between nocturnal sleep duration and the risk of hyperuricemia among Chinese government employees: A cross-sectional study

Prevalence of hyperuricaemia among adults from Ningxia Hui Autonomous Region, China: a cross-sectional study

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