Effects of one minute and ten minutes of walking activity in rats with arthritis induced by complete Freund's adjuvant on pain and edema symptoms

Gomes, Raquel Pinheiro; Bressan, Elisângela; Silva, Tatiane Morgana da; Gevaerd, Monique da Silva; Tonussi, Carlos Rogério; Domenech, Susana Cristina

doi:10.1016/j.rbre.2014.03.001

Cited by 8 publications

(10 citation statements)

References 15 publications

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“…[41][42][43] CFA initially induces edema and soft tissue thickening at the injection site, followed by a late phase flare, with activation of the immune system, and the development of overt RA and other systemic inflammatory events. 42,44 The development of nodules in different organs such as the ears, nose, and tail is a characteristic clinical manifestation of RA associated with disease severity, [41][42] which was evident in the current study. In addition, a reduction in the arthritic score is a direct function of a compound's anti-inflammatory activity.…”

Section: Discussionsupporting

confidence: 62%

Functional Role of Novel Anthranilic Acid Derivatives as Anti-inflammatory Agents

Morsy¹,

Patel²,

Parmar³

et al. 2022

Ind. J. Pharm. Edu. Res

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Background:The discovery of new cyclooxygenase (COX) inhibitors with high efficacy and safety would greatly aid in developing anti-inflammatory drugs. This study evaluated the anti-inflammatory activity and the expected side effect of two synthesized anthranilic acid derivatives (JS-3 and JS-4). Materials and Methods: The COX selectivity of compounds was assessed in a whole blood assay. The results were confirmed by molecular docking studies. In vivo anti-inflammatory activity was tested in complete Freund's adjuvant (CFA)-induced rheumatoid arthritis (RA) in rats. The safety profile was determined by administering a dose three times the therapeutic dose. Results: In vitro COX-2 selectivity of JS-4 was higher than JS-3 (13.70 vs. 5.56). Docking studies supported the higher selectivity of both derivatives against COX-2 than mefenamic acid. Treatment of CFA-arthritic rats with both compounds showed significant (P < 0.01) decreases in paw volume, paw thickness, arthritic index, and inflammatory parameters such as rheumatoid factor, interleukin (IL)-1β, IL-6, prostaglandin (PG) E 2 , PGI 2 , and TXB 2 compared to untreated RA animals. JS-3 and JS-4 improved knee joint histopathology and protected against RA-induced pathological changes: splenomegaly, thymomegaly, and cardiomyopathy. Both derivatives produced minimal effects on liver and renal functions, without any ulcerogenic effects. Conclusion: These results suggest that JS-4 is a potential and safe candidate for managing RA without renal, liver, gastrointestinal, or cardiovascular toxicity.

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Section: Discussionsupporting

confidence: 62%

Functional Role of Novel Anthranilic Acid Derivatives as Anti-inflammatory Agents

Morsy¹,

Patel²,

Parmar³

et al. 2022

Ind. J. Pharm. Edu. Res

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show abstract

“…It has been modified to limit the inflammatory process to a single joint (monoarthritis) in an attempt to cause a less intense arthritis, thus avoiding the severe discomfort, stress on the animals, altered weight gain and systemic disease. Most modifications have involved the local injection of CFA either into Butler et al [32] or around the tibiotarsal joint Donaldson et al [33]; Gomes [19]. We chose the last route of administration as the most appropriate in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Paw diameter (oedema) and withdrawal threshold (inflammatory pain) were evaluated every hour during the next 6 hours after booster injection on D(0) and once on D(1) (acute phase); D(3), D(5) and D(7)(sub-acute phase); D(10) and D(14) (chronic phase). The measurements of each arthritic rat parameters were blindly carried out on triplicate by a skilled observer, according to Gomes [19] with modifications.…”

Section: Induction and Evaluationmentioning

confidence: 99%

Antinociceptive and Anti-inflammatory Effects of the Hydroalcoholic Fraction from Leaves of Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae) in Rodents

Cavalcanti¹

2017

OROAJ

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Introduction: Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae) is locally known as "caneleiro" and its barks, leaves and flowers are used in folk medicine against stomach disorders and abdominal pain. HPLC analysis of hydroalcoholic fraction from leaves (Cm-HAF) indicated two biflavones as main constituents: agathisflavone and amentoflavone.Purpose: To investigate antinociceptive and anti-inflammatory/antiarthritic effects of Cm-HAF in animal models. Materials and Methods:We used male Swiss mice (25-30 g) and female Wistar rats (150-210 g). Acute antinociception was evaluated using formalin, capsaicin and glutamate tests. Complete Freund´s adjuvant (CFA)-induced monoathritic rats were treated with Cm-HAF (50, 100 and 200 mg/kg p.o.) for 15 days and evaluated for acute D (0-1), sub-acute D (3-7) and chronic D (10-14) anti-inflammatory (paw edema) and antinociceptive effects (mechanical nociception). Histological evaluation of paws, blood urea nitrogen (BUN), creatinine and alanine-amino transferase (ALT) dosage, total body weight variation, wet weight of kidneys and liver and macroscopical evaluation of gastric mucosae were performed on D (14).Results: Cm-HAF produced significant antinociceptive effect in capsaicin, glutamate tests and in the late phase of formalin test. CFA-induced monoarthritic rats treated with Cm-HAF (50, 100 and 200 mg/kg p.o.) showed no significant differences on paw diameter or histological evaluation, but showed a significant antinociception (Cm-HAF 100 and 200 mg/kg p.o.) similar to indomethacin (IND -3 mg/kg p.o.). Conclusion:Cm-HAF has antinociceptive but not antiedematogenic/antiarthritic effects in rodents. These results contribute to the pharmacological knowledge of this species and support its ethnomedical use.

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“…Within sources which used CFA models, the dose administered also varied significantly. CFA models injected either 0.025 mg in 25 μl saline (single intra-articular injection in the knee) ( Pitcher et al, 2017 ) or 1 mg in 100 μl saline (this study used two injections; one injection of 0.5 mg in 50 μl saline intradermally in the tail tip and then the second injection administered to the femorotibial or tibiotarsal joint 21 days later) ( Gomes et al, 2014 ). Apart from the study by Gomes et al ( Gomes et al, 2014 ), all other sources in this review used intraarticular injection of a chemical agent to stimulate a model of arthritis in rats.…”

Section: Intra-articular Models Of Arthritismentioning

confidence: 99%

Therapeutic exercise interventions in rat models of arthritis

Derue¹,

Ribeiro‐da‐Silva²

2023

Neurobiology of Pain

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Effects of one minute and ten minutes of walking activity in rats with arthritis induced by complete Freund's adjuvant on pain and edema symptoms

Cited by 8 publications

References 15 publications

Functional Role of Novel Anthranilic Acid Derivatives as Anti-inflammatory Agents

Functional Role of Novel Anthranilic Acid Derivatives as Anti-inflammatory Agents

Antinociceptive and Anti-inflammatory Effects of the Hydroalcoholic Fraction from Leaves of Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae) in Rodents

Therapeutic exercise interventions in rat models of arthritis

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