Therapeutic exercise interventions in rat models of arthritis

Derue, Hannah; Ribeiro‐da‐Silva, Alfredo

doi:10.1016/j.ynpai.2023.100130

Cited by 3 publications

(10 citation statements)

References 55 publications

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“…Arthritic mice treated with exercise showed slower disease progression, thicker knee cartilage, and lower TNF-α levels compared to a control group [94]. The benefits of physical exercise on joint pathophysiology were reviewed by Derue and Ribero-da-Silva [93]. Running wheels, treadmills, or Improving drug efficacy in animal models of arthritis can be achieved by testing compounds in the presence of EE (Figure 4).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…Running wheels, treadmills, or Improving drug efficacy in animal models of arthritis can be achieved by testing compounds in the presence of EE (Figure 4). A number of preclinical studies in animal model of arthritis evaluated the effects of physical exercise [93][94][95][96]. Arthritic mice treated with exercise showed slower disease progression, thicker knee cartilage, and lower TNF-α levels compared to a control group [94].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…Arthritic mice treated with exercise showed slower disease progression, thicker knee cartilage, and lower TNF-α levels compared to a control group [94]. The benefits of physical exercise on joint pathophysiology were reviewed by Derue and Ribero-da-Silva [93]. Running wheels, treadmills, or other exercise-based interventions in animal models improved preserved bone structure, downregulation of inflammatory signaling, improvement in weight asymmetry, and reduced pain compared to sedentary mice [93].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…The benefits of physical exercise on joint pathophysiology were reviewed by Derue and Ribero-da-Silva [93]. Running wheels, treadmills, or other exercise-based interventions in animal models improved preserved bone structure, downregulation of inflammatory signaling, improvement in weight asymmetry, and reduced pain compared to sedentary mice [93]. EE in the form of larger cages, running wheels, toys, and other enrichments ameliorated inflammatory changes, reduced acute edema, and increased expression of BDNF in the hippocampus among arthritic mice [97].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

See 3 more Smart Citations

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Biskupiak,

Ha,

Rohaj

et al. 2024

JCM

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Limitations of pharmaceutical drugs and biologics for chronic diseases (e.g., medication non-adherence, adverse effects, toxicity, or inadequate efficacy) can be mitigated by mobile medical apps, known as digital therapeutics (DTx). Authorization of adjunct DTx by the US Food and Drug Administration and draft guidelines on “prescription drug use-related software” illustrate opportunities to create drug + digital combination therapies, ultimately leading towards drug–device combination products (DTx has a status of medical devices). Digital interventions (mobile, web-based, virtual reality, and video game applications) demonstrate clinically meaningful benefits for people living with Alzheimer’s disease, dementia, rheumatoid arthritis, cancer, chronic pain, epilepsy, depression, and anxiety. In the respective animal disease models, preclinical studies on environmental enrichment and other non-pharmacological modalities (physical activity, social interactions, learning, and music) as surrogates for DTx “active ingredients” also show improved outcomes. In this narrative review, we discuss how drug + digital combination therapies can impact translational research, drug discovery and development, generic drug repurposing, and gene therapies. Market-driven incentives to create drug–device combination products are illustrated by Humira® (adalimumab) facing a “patent-cliff” competition with cheaper and more effective biosimilars seamlessly integrated with DTx. In conclusion, pharma and biotech companies, patients, and healthcare professionals will benefit from accelerating integration of digital interventions with pharmacotherapies.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…Arthritic mice treated with exercise showed slower disease progression, thicker knee cartilage, and lower TNF-α levels compared to a control group [94]. The benefits of physical exercise on joint pathophysiology were reviewed by Derue and Ribero-da-Silva [93]. Running wheels, treadmills, or other exercise-based interventions in animal models improved preserved bone structure, downregulation of inflammatory signaling, improvement in weight asymmetry, and reduced pain compared to sedentary mice [93].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Rheumatoid Arthritismentioning

confidence: 99%

See 2 more Smart Citations

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Biskupiak,

Ha,

Rohaj

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…It has been shown that regular physical activity, specifically wheel running, can produce analgesia through central inhibitory control involving opioidergic and serotoninergic systems in a mouse model of chronic muscle hyperalgesia [24]. A recent narrative review highlighted that many studies investigating the role of exercise in rodent models of arthritis, including OA, focused on molecular and pathophysiological joint changes as indicators of successful intervention without investigating pain behavior [25].…”

Section: Introductionmentioning

confidence: 99%

Face and Predictive Validity of MI-RAT (Montreal Induction of Rat Arthritis Testing), a Surgical Model of Osteoarthritis Pain in Rodents Combined with Calibrated Exercise

Otis,

Bouet,

Keita-Alassane

et al. 2023

IJMS

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Validating animal pain models is crucial to enhancing translational research and response to pharmacological treatment. This study investigated the effects of a calibrated slight exercise protocol alone or combined with multimodal analgesia on sensory sensitivity, neuroproteomics, and joint structural components in the MI-RAT model. Joint instability was induced surgically on day (D) 0 in female rats (N = 48) distributed into sedentary–placebo, exercise–placebo, sedentary–positive analgesic (PA), and exercise–PA groups. Daily analgesic treatment (D3–D56) included pregabalin and carprofen. Quantitative sensory testing was achieved temporally (D–1, D7, D21, D56), while cartilage alteration (modified Mankin’s score (mMs)) and targeted spinal pain neuropeptide were quantified upon sacrifice. Compared with the sedentary–placebo (presenting allodynia from D7), the exercise–placebo group showed an increase in sensitivity threshold (p < 0.04 on D7, D21, and D56). PA treatment was efficient on D56 (p = 0.001) and presented a synergic anti-allodynic effect with exercise from D21 to D56 (p < 0.0001). Histological assessment demonstrated a detrimental influence of exercise (mMs = 33.3%) compared with sedentary counterparts (mMs = 12.0%; p < 0.001), with more mature transformations. Spinal neuropeptide concentration was correlated with sensory sensitization and modulation sites (inflammation and endogenous inhibitory control) of the forced mobility effect. The surgical MI-RAT OA model coupled with calibrated slight exercise demonstrated face and predictive validity, an assurance of higher clinical translatability.

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A Comparative Study of CFA and MIA Induction Models in Rat Knee Arthritis

Normasari,

Purwanto,

Tinduh

2024

Pharmacogn J.

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This study presents another comparative review of knee joint arthritis induction in rats using two distinct methods: Complete Freund's Adjuvant (CFA) and monosodium iodoacetate (MIA). Different variables are assessed, including bodyweight changes, knee bend scores, and knee diameter measurements, as well as the quantification of interleukin-1β (IL-1β) and C-telopeptide of type II collagen (CTX-II) levels. CFA or MIA induction was used on rats, and 14 days were observed. Our data show that the impact of arthritis induction varies significantly across the two models. Both the CFA and MIA groups showed different changes in terms of bodyweight changes, knee bend scores, and knee diameter variations. Furthermore, the levels of IL-1β and CTX-II, both known indicators of inflammation and cartilage degeneration, were measured. Notably, IL-1β levels in the CFA group were considerably higher than in the MIA-induced rats, although CTX-II concentrations showed a contrary pattern. These findings highlight the need to carefully consider the induction approach when performing arthritis investigations in rats since the model used has a major impact on the reported physiological alterations. This study's comparative analysis provides useful information for researchers looking to use rat knee joint arthritis models, laying the groundwork for a better-informed selection of the best induction strategy depending on desired outcome metrics.

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Therapeutic exercise interventions in rat models of arthritis

Cited by 3 publications

References 55 publications

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Face and Predictive Validity of MI-RAT (Montreal Induction of Rat Arthritis Testing), a Surgical Model of Osteoarthritis Pain in Rodents Combined with Calibrated Exercise

A Comparative Study of CFA and MIA Induction Models in Rat Knee Arthritis

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