Effects of obesity and hormone therapy on surgically-confirmed fibroids in postmenopausal women

Abstract

To examine the association between body mass index (BMI), use of menopausal hormone therapy (HT), and incidence of uterine fibroids in postmenopausal women, 610,604 postmenopausal women without prior hysterectomy or diagnosis of fibroids were followed as part of a large United Kingdom prospective cohort study. We used Cox regression models to calculate adjusted relative risks (RRs) of surgically-confirmed fibroids (defined as a hospital admission with uterine fibroids as a primary diagnosis with a related surgical procedure), in relation to BMI and use of HT. During an average of 11.4 years of follow-up, 3561 women were admitted to hospital with surgically-confirmed fibroids. Five-year incidence rates decreased with age, from 0.50 % (1 in 200 women) at age 50–54, to 0.11 % (1 in 1000 women) at age 75–79. The 5-year rate in postmenopausal women aged 50–54 was about a quarter that seen in premenopausal women of the same age (1 in 200 vs. 1 in 50). Compared with normal weight women, obese women had a RR of surgically-detected fibroids of 1.46 (95 % CI 1.33–1.59; p < 0.0001). HT use was associated with a RR of 2.33 (95 % CI 2.18–2.49; p < 0.0001) in ever versus never users. When we analysed HT use and BMI together, obese vs. normal weight never users had a RR of 2.00 (95 % CI 1.77–2.26): the highest risks were seen in women who were obese and had ever used HT, RR = 3.30 (95 % CI 2.88–3.79). Uterine fibroids continue to occur in postmenopausal women; obesity and hormone therapy use are important modifiable risk factors.

Recurrence factors and reproductive outcomes of laparoscopic myomectomy and minilaparotomic myomectomy for uterine leiomyomas

“…According to Sparic et al [16], obesity do not have consistent association with the risk of leiomyomas. However, some articles claim that obesity can increase the risk of leiomyomas [171819]. In this study, the mean BMI was higher in the MM group than that in the LM group.…”

Premenapozal Kadınlarda Myoma Uteri Gelişimi Üzerine Visseral/Trunkal Yağ Oranının ve İnsülin Direncinin Etkisinin Değerlendirilmesi

“…9 In a study investigating the relationship between myoma and obesity, it has been found that obesity increases the risk of myoma by 46% regardless of the hormone replacement therapy in patients receiving hormone replacement therapy. 17 These controversial results in the literature suggest the need for studies with larger series.…”

Body condition scoring system for greater one-horned rhino (Rhinoceros unicornis): Development and application

“…In humans, obesity is one among the many factors often mentioned to increase the risk for leiomyoma [Ross et al, 1986;Shikora et al, 1991;Sato et al, 1998;Faerstein et al, 2001;Wise et al, 2005;Takeda et al, 2008;Yang et al, 2014;Sommer et al, 2015]. Parous women appear to have a lower risk of uterine leiomyoma than nulliparous women [Ross et al, 1986;Parazzini et al, 1988Parazzini et al, , 1996Wise et al, 2004].…”