Effects of oat β-glucan on endurance exercise and its anti-fatigue properties in trained rats

Xu, Chao; Lv, Junli; Lo, Y. Martin; Cui, Steve W.; Hu, Xinzhong; Fan, Mingtao

doi:10.1016/j.carbpol.2012.10.023

Cited by 92 publications

(65 citation statements)

References 39 publications

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“…Physical fatigue, a complex condition, is described as a time-dependent, exercise-induced reduction in the maximal force-generating capacity of a muscle (8). Intense exercise results in the accumulation of reactive free radicals and leads to the consumption of adenosine triphosphate (ATP) and glycogen (9). Energy metabolism is involved in the pathophysiology of fatigue, and hypoxia, which occurs during acute and chronic vascular disease, cancer and stroke, is defined as a decrease in the normal level of tissue oxygen tension (10).…”

Section: Introductionmentioning

confidence: 99%

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Wang

Liu

et al. 2015

Molecular Medicine Reports

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Abstract. Paecilomyces hepiali, one of the most valuable and effective Chinese medicinal herbs, possesses potential antioxidant, immunomodulatory, antitumor and anti-inflammatory properties. The present study aimed to investigate the antifatigue and antihypoxic effects of Paecilomyces hepiali extract (PHC) in a mouse model. Using a rotating rod, forced swimming and running assessment, the antifatigue activity of PHC was determined. PHC administration for 7 days had no effect on mouse horizontal or vertical movement, indicating no neurotoxicity at the selected doses was observed. Using a normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia assessments, PHC was confirmed to possess antihypoxic effects. PHC treatment for 7 days significantly enhanced the serum and liver levels of adenosine triphosphate, superoxide dismutase and glutathione peroxidase, prior to and following 60 min of swimming. The levels of antioxidant-associated proteins in the livers of the mice were analyzed using western blotting. PHC effectively increased the expression levels of phosphorylated (p)-5'-monophosphate (AMP)-activated protein kinase (AMPK), p-protein kinase B (AKT) and p-mammalian target of rapamycin (mTOR). The results of the present study demonstrated that PHC efficiently enhanced endurance from fatigue and had antihypoxic effects through elevation of the antioxidant capacity in the serum and liver, at least in part through the AMPK and AKT/mTOR pathways. These results indicate the potential of this natural product as an antioxidant in the treatment of fatigue, hypoxia and their associated diseases.

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Section: Introductionmentioning

confidence: 99%

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Wang

Liu

et al. 2015

Molecular Medicine Reports

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“…An optimal application of β-glucan in individuals with heavy physical stress reduced respiratory illnesses, increased phagocytic and NK cell activity [22]. Several experiments demonstrated that glucan treatment after stress resulted in the decrease of lactate levels, lower activity of creatinine kinase as well as additional markers demonstrating stronger endurance during higher stress [23]. Effects of β-glucans on activation of macrophages and neutrophils together with their stimulation of phagocytosis, cytotoxicity and antimicrobial activity via activation of specific receptors (such as CR3, Dectin-1, lactosyl or TLR2-6) are well established (for review see [24]) and can be utilized in suppression of stress of our group of children.…”

Section: Discussionmentioning

confidence: 99%

Effects of Transfer Point Glucan #300 Supplementation on Children exposed to Passive Smoking - Placebo-driven Double-blind Clinical Trials

Richter¹,

Vlastimil²,

Svozil³

et al. 2014

Journal of Nutrition and Health Sciences

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“…Algunos cereales como la avena y la cebada, son capaces de producir -glucanos no ramificados de enlaces mixtos -1,3 y -1,4 (Fig. 3), los cuales han atraído gran interés en investigación debido a su capacidad de interactuar con el sistema inmune de vertebrados (Xia et al 1999, Tada et al 2009), potenciar la acción probiótica de bacterias benéficas (MetzlerZebeli & Zebeli 2013, Arena et al 2014, inducir posibles efectos positivos contra el colesterol y la obesidad (Lin et al 2013), así como mejorar el rendimiento al realizar actividad física (Xu et al 2013). Otro tipo de -glucano que está presente en plantas es la callosa, que presenta 1,3--glucano lineal no ramificado formando parte de tejidos de plantas embriofitas en paredes celulares especializadas o en estructuras asociadas a pared en etapas particulares de diferenciación (Stone 2009).…”

Section: -Glucanos: Potencial Como Nutracéuticos Y Organismos Producunclassified

B-glucans, production and properties in microalgae with emphasis on Nannochloropsis genus (Ochrophyta, Eustigmatales)

Espinoza-Gallardo

Contreras–Porcia

Ehrenfeld

2019

Rev. biol. mar. oceanogr.

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Las microalgas son microorganismos eucariontes fotosintéticos capaces de producir una amplia gama de compuestos de interés comercial, tales como vitaminas, antioxidantes, ácidos grasos omega-3 e inmunoestimulantes como los B-glucanos. Los B-glucanos son polímeros de D-glucosa unidos por enlaces B-1,3 o B-1,4 los cuales pueden presentar ramificaciones de enlaces B-1,6. Los más conocidos en microalgas son el paramilón (presente en euglenoides) y la crisolaminarina (presente en diatomeas). En el género Nannochloropsis, (Ochrophyta), la secuenciación de los genomas y los transcriptomas de algunas de sus especies ha evidenciado que también serían capaces de sintetizar B-glucanos de enlaces B-1,3 con ramificaciones B-1,6. Si bien, existen pocos estudios con respecto a dichos compuestos en estas especies, se sugiere que corresponderían a moléculas de reserva energética de carbono, que reemplazan el almidón y que presentan un comportamiento similar al de los lípidos de reserva como el triacilglicerol (TAG). Por lo que, pueden competir por las mismas moléculas precursoras derivadas de la fijación de carbono. La presencia de los B-glucanos junto con su caracterización y la validación de sus propiedades beneficiosas para la salud humana, pueden otorgar un potencial interés económico al cultivo de Nannochloropsis. Estos cultivos, han adquirido un enorme interés debido a su alto contenido de TAG para la producción de biodiesel o ácido eicosapentanoico (EPA) para la alimentación de rotíferos, peces y humanos con fines nutracéuticos. Esta revisión tiene como finalidad evidenciar las propiedades de los B-glucanos en microalgas y el uso potencial de Nannochloropsis en la producción de esas moléculas.

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Effects of oat β-glucan on endurance exercise and its anti-fatigue properties in trained rats

Cited by 92 publications

References 39 publications

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Effects of Transfer Point Glucan #300 Supplementation on Children exposed to Passive Smoking - Placebo-driven Double-blind Clinical Trials

B-glucans, production and properties in microalgae with emphasis on Nannochloropsis genus (Ochrophyta, Eustigmatales)

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