Effects of non‐surgical periodontal therapy on inflammatory markers of psoriasis: A randomized controlled trial

Yarkaç, Fatma Uçan; Oğrum, Atiye; Göktürk, Özge

doi:10.1111/jcpe.13205

Cited by 9 publications

(10 citation statements)

References 64 publications

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“…This finding is in line Fadel et al, 15 although both groups of their study showed a suboptimal oral hygiene level. Although Skudutyte-Rysstad et al 12 and Yarkac et al 24 observed significantly higher mean values of BOP in the psoriasis group, Kathariya and Pradeep 23 observed that PI and gingival index were significantly higher in the psoriasis group. In our study, 80% of the patients in the case group were using a systematic immunosuppressive medication.…”

Section: Discussionmentioning

confidence: 88%

Higher Prevalence of Periodontitis and Decayed, Missing and Filled Teeth in Patients with Psoriasis

et al. 2020

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Objective The aim of this study is to describe the prevalence and severity of periodontitis and decayed, missing and filled teeth (DMFT) index in patients with psoriasis. As a secondary aim, verify if periodontitis was a risk indicator for psoriasis. Materials and Methods A total of 69 patients diagnosed with psoriasis (48.7 ± 14.6 years) and 74 healthy controls (40.3 ± 12.9 years) participated in the study. Probing pocket depth, clinical attachment loss (CAL), bleeding on probing, plaque index, and DMFT index were measured in all subjects. Periodontitis was defined as the presence of at least three interproximal sites with CAL ≥3 mm in different teeth and severe periodontitis should involve at least two interproximal sites in different teeth with CAL ≥5 mm. Statistical Analysis The Mann–Whitney test was used to analyze the demographics and the clinical data. The significance level was 5%. A multivariate logistic regression was conducted, and the odds ratio were calculated to express the risk to develop psoriasis. Results Patients with psoriasis had significantly more sites with CAL ≥3 mm (p < 0.03) and CAL ≥5 mm (p < 0.0001), less sites with plaque (p < 0.0001), fewer teeth (p < 0.0001), and a high DMFT index (p < 0.02) as compared with controls. Severe periodontitis was significantly more frequent (87.1% × 58.1%) and was a risk indicator for psoriasis after adjusting for sex, age, race, and smoking habits (odds ratio: 3.7, 95% confidence interval: 1.5–9.0, p < 0.003). Conclusion Patients with psoriasis have higher prevalence of severe periodontitis and higher DMFT than control patients. Severe periodontitis may be a risk indicator for psoriasis.

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Section: Discussionmentioning

confidence: 88%

Higher Prevalence of Periodontitis and Decayed, Missing and Filled Teeth in Patients with Psoriasis

et al. 2020

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“…In addition, effective periodontal therapy in psoriatic patients may improve the skin condition, which Ucan Yarkac et al . showed in their study 22 . The co‐occurrence of psoriasis and periodontitis affects the quality of life and the negative impact increases with the severity of both diseases 23 .…”

Section: Discussionmentioning

confidence: 93%

“…The elimination of inflammation foci in the oral cavity is essential in order to avoid psoriasis exacerbation and harmful side effects of systemic and biological agents 3,12 . Only nine subjects (7.1%) required periodontal therapy compared to the findings of Szpak (19.8%), which seems to be a good outcome according to Ucan Yarkac 22,26 …”

Section: Discussionmentioning

confidence: 98%

Oral health status and dental treatment needs of psoriatic patients with different therapy regimes

Olejnik

Adamski

Osmola‐Mańkowska

et al. 2021

Australian Dental Journal

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The aim of the study was to investigate the dental treatment requirements and oral health status of psoriatic patients with different severities of the disease, managed by different methods, including biological therapies. Methods One hundred and twenty‐seven patients diagnosed with psoriasis were enrolled in this study. All subjects completed a general medical history and a Dermatology Life Quality Index (DLQI) questionnaire. The severity of the disease was assessed using the Psoriasis Area and Severity Index (PASI) scale and a DLQI questionnaire. In order to evaluate the oral health status, the following techniques were used: Approximal Plaque Index (API), the Community Periodontal Index (CPI) and the Decayed, Missing and Filled Teeth (DMFT) index. Results Patients treated with biologicals presented a significantly lower mean CPI index and required no surgical interventions. Subjects managed with topical therapy had significantly more decayed teeth and higher treatment needs. Only 11.3% of patients did not require dental intervention. Conclusions The study revealed a high need for dental interventions in patients with psoriasis. The type of treatment used may affect the oral health status of patients. However, further investigations are required to explain the significantly lower CPI value in the group treated with biologicals.

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“…proposed that periodontitis may play a direct or indirect role in the occurrence or exacerbation of PsO through the immunomodulatory effect of oral microbiota, and may affect the efficacy of anti-PsO treatment ( 94 ). Periodontal basic treatment can reduce the severity of PsO while improving periodontal status and reducing the expression level of inflammatory factors in saliva ( 95 ). Treatment of PsO with TNF-α inhibitors can also slow down the progression of periodontitis ( 96 ).…”

Section: Role Of Il-17a In the Relationship Between Periodontitis And...mentioning

confidence: 99%

Role of Interleukin-17A in the Pathomechanisms of Periodontitis and Related Systemic Chronic Inflammatory Diseases

Feng

Chen

et al. 2022

Front. Immunol.

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Periodontitis is a chronic inflammatory and destructive disease caused by periodontal microbial infection and mediated by host immune response. As the main cause of loosening and loss of teeth in adults, it is considered to be one of the most common and serious oral diseases in the world. The co-existence of periodontitis and systemic chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, inflammatory bowel disease, diabetes and so on is very common. It has been found that interleukin-17A (IL-17A) secreted by various innate and adaptive immune cells can activate a series of inflammatory cascade reactions, which mediates the occurrence and development of periodontitis and related systemic chronic inflammatory diseases. In this work, we review the role of IL-17A in the pathomechanisms of periodontitis and related systemic chronic inflammatory diseases, and briefly discuss the therapeutic potential of cytokine targeted agents that modulate the IL-17A signaling. A deep understanding of the possible molecular mechanisms in the relationship between periodontitis and systemic diseases will help dentists and physicians update their clinical diagnosis and treatment ideas.

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Effects of non‐surgical periodontal therapy on inflammatory markers of psoriasis: A randomized controlled trial

Cited by 9 publications

References 64 publications

Higher Prevalence of Periodontitis and Decayed, Missing and Filled Teeth in Patients with Psoriasis

Higher Prevalence of Periodontitis and Decayed, Missing and Filled Teeth in Patients with Psoriasis

Oral health status and dental treatment needs of psoriatic patients with different therapy regimes

Role of Interleukin-17A in the Pathomechanisms of Periodontitis and Related Systemic Chronic Inflammatory Diseases

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