Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: II. Corynebacterium parvum

Abstract

The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). The host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.018), resulting in 44% protection. The "in vivo" leukocyte response in both prophylactic and curative groups was higher as compared to the infected/non treated group (p = 0.009 and p = 0.003, respectively). Tissue reactions were described in the experimental and control groups, but there were not remarkable differences among them. The possible biological implications and relevance of the findings for the defensive response of the host and control of schistosomiasis are discussed.

Adjuvant effect of LPS and killedPropionibacterium acneson the development of experimental gastrointestinal nematode infestation in sheep

“…It is well known that the treatment of animals with killed P. acnes increases lymphocyte population such as B lymphocytes, TCD4 + , TCD8 + and NKT cells, and potentiates their functions (13,24,26). The increase on animal resistance to several infections was also observed after killed P. acnes animal treatment (27–31).…”

“…On the other hand, several clinical and experimental studies in vivo and in vitro reported the effects of killed Propionibacterium acnes suspension on innate and adaptive immune response modulation. Among these, it was observed increase on the phagocytic and tumoricidal macrophages activities (21–24), adjuvant effect in the antibody response (25,26) and augmentation of the animal resistance to different types of pathogens (27–31).…”

Modulatory Effect of Killed Propionibacterium acnes and Its Purified Soluble Polysaccharide on Peritoneal Exudate Cells from C57Bl/6 Mice: Major NKT Cell Recruitment and Increased Cytotoxicity

“…When such bacterial suspension is administered to human and experimental animals, it induces biological effects that modulate the innate and acquired immune responses. One of the most important P. acnes adjuvant effects is the increase in macrophage phagocytic activity [1,2], which can explain, in part, the bacterium ability to enhance animal resistance to several pathogens [3][4][5][6][7][8][9]. It also enhances a tumoricidal macrophage activity, as demonstrated in several experimental and clinical studies [10][11][12][13][14][15].…”

In vivo and in vitro effect of killed Propionibacterium acnes and its purified soluble polysaccharide on mouse bone marrow stem cells and dendritic cell differentiation

“…It has been extensively studied for its immunomodulatory effects when administered as killed bacteria in experimental models. Killed P. acnes increases lipopolysaccharide (LPS)-induced endotoxic shock (Green et al, 1977), activates the mononuclear phagocytic system (Halpern et al, 1963), induces tumoricidal activity Halpern et al, 1966;Woodruff et al, 1974), acts as adjuvant for antibody response Warr and James, 1975) and enhances resistance to infections (Abath et al, 1988;Brener and Cardoso, 1976;Ha et al, 1986;Hill, 1987;Nussenzweig, 1967;Squaiella et al, 2001;Teixeira et al, 1996).…”