Effects of non‐invasive, 1,210 nm laser exposure on adipose tissue: Results of a human pilot study

Wanner, Molly; Avram, Mathew M.; Gagnon, Denise; Mihm, Martín C.; Zurakowski, David; Watanabe, Katsueki; Tannous, Zeina; Anderson, R. R.; Manstein, Dieter

doi:10.1002/lsm.20785

Cited by 48 publications

(19 citation statements)

References 30 publications

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“…Numerous delivery mechanisms have been developed to achieve body slimming without surgery. Subcutaneous adipocyte destruction has been investigated with numerous technologies including: ultrasound, infrared, radio frequency and cryolipolysis 1–6. High‐intensity focused ultrasound (HIFU) is currently considered an adjunct to, rather than a replacement for liposuction.…”

Section: Background and Objectivesmentioning

confidence: 99%

Efficacy of a multiple diode laser system for body contouring

Elm¹,

Wallander²,

Endrizzi

et al. 2011

Lasers Surg Med

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Section: Background and Objectivesmentioning

confidence: 99%

Efficacy of a multiple diode laser system for body contouring

Elm¹,

Wallander²,

Endrizzi

et al. 2011

Lasers Surg Med

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“…The method is based on the combined photochemical and photothermal effect [2,207] induced in the fat tissue cells. The selective photothermal action on the fat tissue can be implemented by the laser radiation wavelength choice using the absorption by the endogenous (own) tissue chromophores, in the present case the lipids contained in the fat drop of adipocytes, under the exposure to light with the wavelength 1210 nm [208]. However, with exogenous chromophores, e.g., the indocyanine green (ICG), the efficiency of light interaction with tissue may be essentially higher and more selective [209][210][211][212][213].…”

Section: Photochemical and Photothermal Clearingmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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Abstract.A review of specific features and methods of optical clearing and related interaction of light with tissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular tissues are discussed. The possibility of efficient control of the tissue optical properties, particularly, the reduction of light scattering in tissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposes. © 2015 Samara State Aerospace University (SSAU).Keywords: tissue, optical clearing, optical diagnostics, imaging. 1, 404-413 (1997). 5. C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, "Penetration depth limits of in vivo confocal reflectance imaging," Appl. Opt. 37, 2749Opt. 37, -2754Opt. 37, (1998. 6. V. V. Tuchin, L. V. Wang, and D. A. Zimnyakov, Optical Polarization in Biomedical Applications, SpringerVerlag, New York, NY, USA (2006). 7. R. Drezek, A. Dunn, and R. Richards-Kortum, "Light scattering from cells: finite-difference time-domain simulations and goniometric measurements," Appl. Opt. 38(16), 3651-3661 (1999). 8. K. Sokolov, R. Drezek, K. Gossagee, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light:is it sensitive to cellular and nuclear morphology," Opt. Express 5, 302-317 (1999). 9. D. W. Leonard, and K. M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," Biophysical J. 72, 1382-1387 (1997). 10. A. G. Borovoi, E. I. Naats, and U. G. Oppel, "Scattering of light by a red blood cell," J. Biomed. Opt. 3, 364-372 (1998). 11. A. N. Yaroslavsky, A. V. Priezzhev, J. Rodriguez, I. V. Yaroslavsky, and H. Battarbee, "Optics of blood,"Chap. 2 in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, Ed., pp. 169-216, PM107 SPIE Press, Bellingham, WA, USA (2002). 12. G. Mazarevica, T. Freivalds, and A. Jurka, "Properties of erythrocyte light refraction in diabetic patients," J.Biomed. Opt. 7, 244-247 (2002). 13. M. Friebel, and M. Meinke, "Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration," Appl. Opt. 45(12), 2838-2842 (2006). Appl. Opt. 35(19), 3413-3420 (1996). 34. D. Zhu, J. Wang, Z. Zhi, X. Wen, and Q. Luo, "Imaging dermal blood flow through the intact rat skin with an optical clearing method," J. Biomed. Opt. 15, 026008 (2010 241. K. König, G. Flemming, and R. Hibst, "Laser-induced autofluorescence spectroscopy of dental caries lesion," Cell. Mol. Biol. 44, 1293-1300. 242. E. G. Borisova, T. T. Uzunov, and L. A. Avramov, "Early differentiation between caries and tooth demineralization using laser-induced autofluorescence spectroscopy," Lasers Surg. Med. 34, 249-253 (2004 -20(12), 1512-1516 (1984). 245. K. Konig, H. Schneckenburger, and R. Hibst, "Time-gated in vivo autofluorescence imaging of dental caries,"Cell. Mol. Biol. 45, 233-239 (1999). 246. E. Borisova, P. Tr...

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“…Such an approach is of particular interest during irradiation of biological objects relatively low-lightvisible range, often used in low-intensity laser (light) therapy, for example, in treating venous ulcers, long-term nonhealing wounds, [10][11][12] and photodynamic therapy, 2, 3, 13-15 for selective photothermolysis and photodynamic therapy with the use of indocyanine green as the photosensitizer in oncology. [16][17][18] Various aspects of light on the cells of human adipose tissue are considered in [19][20][21][22][23] . Questions light degradation of adipose tissue, including in combination with selective thermal effect are considered in the papers 8,22,[24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Inhomogeneity of photo-induced fat cell lipolysis

2010

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The effect of optical properties changes of adipose tissue cells in vitro as a result of photoaction was found and investigated. The experimental study of photo-induced post action upon the cells of fat tissue by means of digital microscopy was fulfilled. The computer processing of digital photos obtained gave an opportunity to estimate quantitatively the level of photoaction upon tissue. Optical interpretation of photos obtained proves that the phenomenon observed corresponds to the lipolysis of adipose tissue cells, but without their complete destruction.

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Effects of non‐invasive, 1,210 nm laser exposure on adipose tissue: Results of a human pilot study

Abstract: This in vivo study shows histologic evidence of laser-induced damage of fat. With further development, this might become a useful treatment for disorders involving the fat and/or lower dermis.

Cited by 48 publications

References 30 publications

Efficacy of a multiple diode laser system for body contouring

Efficacy of a multiple diode laser system for body contouring

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Inhomogeneity of photo-induced fat cell lipolysis

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