Effects of nickel chloride on reproduction of the rat and possible antagonistic role of selenium

Käkelä, Reijo; Käkelä, Anne; Hyvärinen, Heikki

doi:10.1016/s0742-8413(99)00006-7

Cited by 41 publications

(45 citation statements)

References 51 publications

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“…Selenium also interacts with nickel, and experiments carried out with Wistar rats indicate that the deleterious effects of NiCl 2 on rat reproduction are antagonized by Na 2 SeO 3 (Se/Ni) [93]. Interactions between Cd, Cu and Pb in relation to the activities of soil urease and dehydrogenase have also been described [94].…”

Section: Other Interactionsmentioning

confidence: 99%

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

et al. 2012

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The fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number of them that provide very good performance. However, biological systems are exposed to a complex environment in which species of elements can interact in a synergistic/antagonistic fashion. Thus, the metabolism of trace elements cannot be considered in isolation. On the other hand, biological systems are dynamic, so it is necessary to study the trafficking of species of elements between organs, tissues or cell compartments in order to decipher the biochemical processes of the interactions in which they are involved. Although the application of liquid chromatography-inductively coupled plasma-based "metallomics" methods in combination with organic mass spectrometry can provide much-needed insight, new analytical strategies are required to really understand the role of species of elements in biological systems and the mechanisms of their interactions. In the present paper, the interactions of the most widely studied elements in this context (Se, Hg and As) are discussed, as well as other important interactions between different elements.

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Section: Other Interactionsmentioning

confidence: 99%

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

et al. 2012

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“…Kakela et al [26] investigated the effect of 10-100 ppm NiCl 2 in drinking water on the reproduction of Wistar rats. In nine experimental groups, females, males or both were exposed to nickel in drinking water.…”

Section: Testicular Effectsmentioning

confidence: 99%

Reproductive toxicology of nickel – Review

Forgács¹,

Massányi

Lukáč

et al. 2012

Journal of Environmental Science and Health, Part A

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The goal of this minireview is to summarize our current knowledge on the reproductive toxicity of soluble nickel salts. We made an attempt to present the most relevant data obtained from in vivo and in vitro experiments performed on mammals, mammalian primary cell cultures and cell lines. Nickel has been demonstrated to disturb the mammalian reproductive functions at several levels of regulation. The results of previous investigations indicate that the hormonal effects may play an important role in the reproductive toxicology of nickel both at the neuroendocrine and gonadal levels in the hypothalamic-pituitary-gonadal (HPG) axis. At the molecular level, it may be important that nickel may substitute certain other metals in metal dependent enzymes, leading to an altered protein function. It readily crosses the cell membrane via calcium channels and competes with calcium for specific receptors. Nickel can cross-link aminoacids to DNA, lead to formation of reactive oxygen species (ROS), moreover mimic hypoxia. These changes may lead to the activation of some signaling pathways, subsequent transcription factors and eventually to alterations in gene expression and cellular metabolism. These events are likely to be involved in the reproductive toxicity of nickel.

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“…From these, Cd, Ni and Pb, are nonessential and can impair various reproduction processes in both sexes [29,30] whereas an altered status of Ca, Cu, Mn, Mg and Zn has been associated with infertility and fetal loss [31]. We also aimed to investigate the relations between metal content in reproductive tissues and lifestyle, environmental and dietary variables.…”

Section: Introductionmentioning

confidence: 99%

Free-ranging domestic cats are characterized by increased metal content in reproductive tissues

Rzymski

Niedzielski

Poniedziałek

et al. 2015

Reproductive Toxicology

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Effects of nickel chloride on reproduction of the rat and possible antagonistic role of selenium

Cited by 41 publications

References 51 publications

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

Reproductive toxicology of nickel – Review

Free-ranging domestic cats are characterized by increased metal content in reproductive tissues

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