Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

García-Barrera, Tamara; Gómez-Ariza, José Luis; González-Fernández, M.; Moreno, Fernando de la Peña; García-Sevillano, M. A.; Gómez-Jacinto, Veronica

doi:10.1007/s00216-012-5776-2

Cited by 63 publications

(36 citation statements)

References 258 publications

(205 reference statements)

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“…The protective effect of selenium on mercury toxicity has been issued in several papers [1][2][3][4][5][6] as well as the antagonist action of selenium against carcinogenic and/or neurotoxic chemicals. [7][8][9] Simultaneous injection of sodium selenite with mercury chloride (at different sites to avoid precipitation) completely protects rats from the characteristic histological changes associated with mercury chloride toxicity. 10 Further studies have demonstrated this protective effect of selenium in mice, 11 pigs, 12 chicken, 13 fishes 2 and rabbits.…”

Section: Introductionmentioning

confidence: 99%

Antagonistic interaction of selenomethionine enantiomers on methylmercury toxicity in the microalgae Chlorella sorokiniana

Moreno¹,

García-Barrera²,

Gómez-Jacinto³

et al. 2014

Metallomics

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The protective effect of selenium against mercury toxicity is well known especially between selenomethionine and methylmercury and it has been studied in several living organisms, however information is lacking about the interaction of these species in Chlorella. Investigation into which chiral form of selenomethionine effectively acts against the toxic effects of methylmercury has not previously been carried out. In the present work, two control cultures and two cultures of C. sorokiniana were grown in standard medium with D,L-SeMet, L-SeMet or D-SeMet. After the experiment was started up MeHg(+) was added periodically to the cultures containing D,L-SeMet, L-SeMet, D-SeMet and to one of the control batches. The results show that both SeMet enantiomers counteract the toxicity of MeHg(+), by markedly increasing the total content of chlorophyll, carotenoids, as well as the dry weight and light dependent oxygen production, compared to the culture which is non pre-treated with SeMet and is only exposed to MeHg(+). The levels of MeHg(+) measured in cells are lower in the cultures pre-treated with SeMet indicating that the passage of MeHg(+) into the cells is negligible when carried out in the presence of SeMet, or that SeMet enhances the release of MeHg(+). On the other hand, L-SeMet is directly involved in the detoxification of MeHg(+), but the involvement of D-SeMet occurs only indirectly since it has been neither identified in the medium nor in C. sorokiniana after supplementation with this enantiomer. It may be that D-SeMet is transformed into SeMeSec and L-SeMet. Moreover, SeMeSec is almost totally released from the cells after 72 hours. No mercury-selenium complex was detected but, since the summation of the different species identified accounted only for 77% of the total selenium and mercury measured directly after sample digestion, it is possible that they are present in the form of an undetected Se-Hg complex. This hypothesis is supported by the decrease of inorganic selenium during the experiment. The present paper reports new data about the relationship between the mechanism of detoxification of methylmercury and selenomethionine enantiomers through the study of the metabolic intermediates by means of speciation analysis.

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Section: Introductionmentioning

confidence: 99%

Antagonistic interaction of selenomethionine enantiomers on methylmercury toxicity in the microalgae Chlorella sorokiniana

Moreno¹,

García-Barrera²,

Gómez-Jacinto³

et al. 2014

Metallomics

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“…Interactions between elements depend on the chemical species and organism type [85]. In rodents, Se prevents As-induced cytotoxicity when arsenite and selenite are simultaneously administered to mice and hamster [86][87][88].…”

Section: Metals Interactions Under Environmental Metal Stressmentioning

confidence: 99%

“…Hg-induced apoptosis [99], represents a defence against methylmercury (MeHg + ) toxicity [100] and causes Hg detoxification [101], between others. The study of species interactions of elements in biological organisms requires experts from various fields such as biology, chemistry, medicine, biochemistry, molecular biology and genetics [85]. In addition, in real environments, animals are exposed to multiple elements that interact among them, so that the assessment of biological response has to be oriented to the toxicological effects caused by the combination of metal/metalloids and their species.…”

Section: Metals Interactions Under Environmental Metal Stressmentioning

confidence: 99%

Omics technologies and their applications to evaluate metal toxicity in mice M. spretus as a bioindicator

García-Sevillano

García-Barrera

Abril

et al. 2014

Journal of Proteomics

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This work presents new contributions in the study of environmental metal pollution in terrestrial ecosystems using Mus spretus mice as bioindicator in Doñana National Park (SW Spain) and surroundings. In addition, it has been demonstrated that the integration of omics multi-analytical approaches provides a very suitable approach for the study of the biological response and metal interactions in exposed and free-living mice (Mus musculus and Mus spretus, respectively) under metal pollution.

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“…Data from such analysis are used to compute mobility and bioavailability of metals [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Speciation of Metals and Risk Assessment in Selected Food Crop Samples Grown in Ohaji/Egbema LGA, Imo State, Nigeria

Wirnkor¹,

Ngozi²,

Obinna³

et al. 2017

J Environ Anal Chem

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Ohaji Egbema is known for its oil production and exploration activities and so crops grown in this area could be contaminated. Chemical speciation was carried out on four commonly grown food crops in the area so as to determine the level of metal contamination. The samples were analyzed sequentially and the metal species in the extract determined by ASS. Results revealed that mean concentrations of all studied metals to fall within the WHO/FAO permissible limits. Significant bioavailability was observed for Pb in Okoro (0.67) and Orange (0.7). Zn showed the highest concentration and its bioavailability was highest for Okoro (12.6)>Pawpaw (7.9)>Orange (5.5)>Cassava (0.28). The sum of EDI for both adult and children exhibited similar trend with Cassava having the least value in both adult and children. Though metals showed low values of EDI, excessive consumption can have adverse effect in humans due to bioaccumulation in living system. Hazard Quotient (HQ) was highest for Pb (3.524) in Pawpaw for children while Fe (0.705) was highest in Pawpaw for adult. Generally, HQ was found to be highest in children for all the metals indicating great health risk for children. Risk associated with consuming these four fruit crops in terms of summation of RAC revealed the order of decrease to be: Okoro (1620)>Pawpaw (1021)>Orange (861)>Cassava (178). This study has shown that the consumption of these fruit crops could be a great health risk for children.

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Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

Cited by 63 publications

References 258 publications

Antagonistic interaction of selenomethionine enantiomers on methylmercury toxicity in the microalgae Chlorella sorokiniana

Antagonistic interaction of selenomethionine enantiomers on methylmercury toxicity in the microalgae Chlorella sorokiniana

Omics technologies and their applications to evaluate metal toxicity in mice M. spretus as a bioindicator

Speciation of Metals and Risk Assessment in Selected Food Crop Samples Grown in Ohaji/Egbema LGA, Imo State, Nigeria

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