Effects of natural polysaccharides on the growth and peritoneal carcinomatosis of human gastric adenocarcinoma in a nude mouse model

Antitumor activity of polysaccharide extracted from Pleurotus ostreatus mycelia against gastric cancer in vitro and in vivo

“…Gastric cancer is a major global public health problem, particularly in Asian and Eastern European countries, where the rate of incidence is 6-8 times greater than in Western countries (28). Even in patients with operable tumors, the proportion of long-term survivors is ~25% worldwide (29).…”

The role of edible mushrooms in health: Evaluation of the evidence

“…Natural polysaccharides isolated from Phellinus gilvus (PG) have been shown to decrease cell proliferation and increase cell apoptosis in a dose-dependent manner in vitro in a model of human gastric adenocarcinoma and also to lead to a marked inhibition of tumor growth and a significant decrease in the incidence of peritoneal carcinomatosis (Bae, Jang, & Jin, 2006). Anti-proliferative (Chen, Zhao, Chen, & Li, 2008) and pro-apoptotic effects (Shomori, Yamamoto, Arifuku, Teramachi, & Ito, 2009) in human gastric cell lines also were reported for several mushroom extracts with both caspase-3 -dependent (Shomori et al, 2009) and independent signaling cascades being implicated (Shomori et al, 2009).…”

Evaluation of water soluble β-d-glucan from Auricularia auricular-judae as potential anti-tumor agent

“…Polysaccharides have attracted more attention recently in the biochemical and medical fields because of their anti-tumor and immunomodulating properties (Zhang, Cui, Cheung, & Wang, 2007). Numerous bioactive polysaccharides are considered as immunomodulators affecting on proliferation and differentiation of immune cells and cytokines, interleukins and receptors production due to recognition these compounds by the certain receptors located on the leukocytes and other immune cells that lead to enhance the innate and cellmediate immune responses (Baea, Janga, & Jinb, 2006;Khalikovaa, Zhanaevaa, Korolenkoa, Kaledinb, & Koganc, 2005;Lavia, Friesemb, Gereshc, Hadarb, & Schwartza, 2006;Moradali, Mostafavi, Ghods, & Hedjaroude, 2007). Some polysaccharides extracted from Chinese herbal medicines have been reported to possess anticancer activities (Chen et al, 2008;Lia et al, 2004).…”