Effects of Na Pentobarbital Anesthesia on Serum Secretin and Exocrine Pancreatic Secretions

Boden, Günther; Ls, Shore; Rm, Wilson; Essa-Koumar, Noorjehan; Jh, Landor

doi:10.1055/s-0028-1093559

Cited by 8 publications

(5 citation statements)

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“…This argument, however, can be discarded. We have shown that a given increase in IRS concentration results in a PBS response which is the same regardless of whether it is achieved by infusion of exogenous secretin or through release of endogenous secretin by acidification (Boden et al, 1977). These observations provide direct evidence that HCI induced PBS is secretin mediated and exclude the release of an inhibitor for PBS.…”

Section: Discussionmentioning

confidence: 53%

Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion.

Boden¹,

Wilson²,

Essa-Koumar³

et al. 1978

Gut

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SUMMARYWe have studied the effect of a protein meal on secretin (IRS) concentration in dogs and humans using a radioimmunoassay of improved sensitivity (8 pg/ml). After a meal, pancreatic bicarbonate secretion (PBS) increased markedly and proximal duodenal pH decreased from 6-2 to 4-3. Portal and peripheral IRS concentrations, however, remained unchanged in eight dogs and five patients with cirrhosis of the liver. Similarly, an alkaline solution of sodium oleate (pH 9-2) stimulated PBS but not IRS. Intraduodenal administration of various amounts of HCl in dogs demonstrated that acid-stimulated PBS was invariably accompanied by rises in peripheral venous IRS concentration. We conclude that the postprandial stimulation of PBS involves mechanisms more complex than acid-stimulated secretin release.

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Section: Discussionmentioning

confidence: 53%

Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion.

Boden¹,

Wilson²,

Essa-Koumar³

et al. 1978

Gut

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“…Additionally, although some reports support its existence (12,21), others do not, as values of 14C-erythritol B/P very close to unity have been observed in some studies (22,23). It is possible that distal bile water reabsorption occurs only under specific experimental conditions, e.g., under pentobarbital anesthesia (21,24), and, therefore, until these are defined, the physiological significance of our finding is uncertain. Nevertheless, it is worth mentioning that preliminary studies in our laboratory (25) suggest that the immaturity of this reabsorptive process is associated with the failure of secretin to stimulate bile flow in the first seven days after birth.…”

Section: Discussionmentioning

confidence: 59%

Postnatal Development of Bile Secretory Physiology in the Dog

Tavoloni,

T. Jones,

Berk

1985

J. pediatr. gastroenterol. nutr.

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To determine whether bile formation in the dog is an immature process at birth, several determinants of bile secretion were studied in anesthetized, bile duct‐cannulated puppies of 0–42 days of age and adult dogs. Basal canalicular bile flow rate, estimated by 14C‐erythritol biliary clearance, averaged 0.182 μl/min/g liver in 0–3 day‐old puppies and increased to 0.324 and 0.461 μl/min/g in puppies 7–21 and 28–42 days of age, respectively. The latter two values were not significantly different from that observed in adult dogs (0.348 μl/min/g). This age‐related increase in canalicular bile flow could be accounted for primarily by an increase in bile acid independent bile flow (0.103, 0.277, 0.375, and 0.252 μl/min/g in 0–3, 7–21, and 28–42 day‐old puppies and adult dogs, respectively). Calculated ductular bile water reabsorption (14C‐erythritol biliary clearance‐bile flow) was virtually absent in 0–3 day‐old puppies (0.005 μl/min/g), and averaged 0.017 and 0.092 μl/min/g in puppies of 7–21 and 28–42 days of age, respectively. In adult dogs, ductular bile water reabsorption was 0.132 μl/min/g. These functional deficiencies of the newborn dog were associated with an increased biliary permeability to 3H‐inulin which could not be accounted for solely by an increased solute diffusion due to the lower rate of canalicular bile flow. Administration of taurocholate up to 2000 nmol/min/kg produced in all animals a similar increase in canalicular bile flow and bile acid excretion, and was not associated with changes in ductular bile water reabsorption rate. These findings are interpreted to indicate that, in the dog, bile secretory function is immature at birth and develops during postnatal life.

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“…This may be related to an inhibitory effect that has been described as a consequence of duodenal perfusion [30]; it may be that this effect is due to the removal of an intraluminal CCK.-releasing peptide [31]. On the other hand, this de crease in protein secretion is a common re sult, even without duodenal perfusion, that has long been described for anesthetized ani mals [32,33].…”

Section: Discussionmentioning

confidence: 99%

Duodenal Alkalinization Releases Secretin and Vasoactive Intestinal Polypeptide and Stimulates Exocrine Pancreatic Secretion in the Anesthetized Rat

García¹,

Minguela²,

Montero³

et al. 1990

Digestion

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The effect of various intraduodenal alkaline solutions (0.1 M NaHCO₃ 0.1 M Na₂CO₃ and 0.025 M NaOH) on exocrine pancreatic secretion and the release of two peptides, secretin and vasoactive intestinal polypeptide, was studied in anesthetized rats. The flow rate of the pancreatic juice was stimulated up to a maximum of 179, 158 and 180 % and the protein output up to 181, 131 and 162% (compared with basal) after duodenal perfusion of, respectively, 0.1 M NaHCO3, 0.1 M Na₂CO₃ and 0.025 M NaOH. Maximum increases in portal plasma secretin concentrations of 143, 146 and 190% and maximum increases in VIP of 116,155 and 147% after, respectively, intraduodenal 0.1 M NaHCO₃, 0.1 M Na₂CO₃, and 0.025 M NaOH were found. In conclusion duodenal alkalinization in the rat produces a pancreatic exocrine secretory response that may be partially ascribed to the effect of secretin and VIP.

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Effects of Na Pentobarbital Anesthesia on Serum Secretin and Exocrine Pancreatic Secretions

Cited by 8 publications

References 0 publications

Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion.

Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion.

Postnatal Development of Bile Secretory Physiology in the Dog

Duodenal Alkalinization Releases Secretin and Vasoactive Intestinal Polypeptide and Stimulates Exocrine Pancreatic Secretion in the Anesthetized Rat

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