Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats

Yang, Seung-Ju; Lee, Woo Je; Kim, Eun-A; Nam, Kee Dal; Hahn, Hoh‐Gyu; Choi, Soo Young; Cho, Sung‐Woo

doi:10.1016/j.ejphar.2014.04.031

Cited by 29 publications

(15 citation statements)

References 62 publications

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“…There are many compounds bearing this fragment which are used in therapy, for treating inflammation [16], oxidative stress [17,18], bacterial infections [19][20][21], hyperglycemia, hyperlipidemia [22], cancer [23][24][25], schizophrenia, hypertension, HIV infection, hypnotics, allergy, etc.…”

Section: Open Accessmentioning

confidence: 99%

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

et al. 2015

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New series of hydrazones 5-18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (−) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14-16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules.

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Section: Open Accessmentioning

confidence: 99%

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

et al. 2015

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“…In fact, other studies have reported an increased NO concentration in serum and tissues (Yang et al, 2014;Sokolovska et al, 2015;Varsha et al, 2015) and inducible nitric oxide synthase (iNOS) overexpression in STZ-induced diabetic rats (AlRejaie et al, 2015). In this context, we observed an increase in NO levels not only in pancreas, but also in the liver and kidneys of DM and/or C. albicans-infected animals, which can be related to the fact that besides of the enhancement in interactions of superoxide with NO in the oxidative diabetic environment, NO is involved in pathogen killing mechanism and contributes to damage in other tissues (Shahani and Sawa, 2011;Samarghandian et al, 2013).…”

Section: Discussionmentioning

confidence: 98%

Anti-inflammatory action of seed extract and polymeric nanoparticles of Syzygium cumini in diabetic rats infected with Candida albicans

Bitencourt¹,

Cargnelutti²,

Stein³

et al. 2017

J App Pharm Sci

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The role of Syzygium cumini against chronic complications of Diabetes mellitus (DM), such as fungal infection and inflammation, has been poorly explored. Here, we evaluated the treatment with S. cumini aqueous seed extract (ASc, 100mg/Kg) and polymeric nanoparticles containing ASc (NPASc, 100mg/Kg) in diabetic rats infected or not by Candida albicans (CA). Male Wistar rats were divided in: control; DM; CA; CA+ASc; CA+NPASc; DM+CA; DM+CA+ASc; and DM+CA+NPASc. Rats were daily treated for 21 days, when glycemic profile, ectonucleotidase (NTPDase and 5'-NT), adenosine deaminase (ADA), acetylcholinesterase (AChE) and dipeptidyl peptidase IV (DPP-IV) activities and nitric oxide (NO) and cytokine levels were analyzed in serum, platelets, lymphocytes and tissues. The results showed that NTPDase, 5'-NT and ADA activities and NO, IL-1, IL-6, TNF-α and IFN-ɣ levels were increased in C. albicans, DM and DM+CA. The treatment with ASc and NPASc decreased ectonucleotidase and AChE activities and NO levels. Both treatments also prevented the increase in ADA activity and pro-inflammatory cytokines in cells and serum. In liver and pancreas, NPASc decreased NO levels more efficiently than ASc. The modulation of ectoenzyme activities can be one of the mechanisms by which S. cumini act on cytokines that affect the development of chronic complications in DM.

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“…ICR mice, a type of outbred rodent, have been frequently applied to produce animal models of diabetes mellitus, but comparative studies of outbred animals obtained from different sources have not been conducted. STZ has been used in the clinical oncology field for the treatment of insulinomas and pancreatic β cell carcinoma [161718], and it has been used in diabetes research as a tool to induce hyperglycemia in laboratory animals [151920]. STZ causes the dysfunction of islet β-cells, including the induction of pancreatic cell apoptosis and inhibition of insulin gene expression and insulin synthesis [2122].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the response using ICR mice derived from three different sources to multiple low-dose streptozotocin-induced diabetes mellitus

et al. 2017

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This study was conducted to compare the multiple low-dose streptozotocin (MLDS)-induced diabetic patterns of Korl:ICR, A:ICR, and B:ICR mice obtained from three different sources. Six-week-old male ICR mice were obtained from three difference sources. Korl:ICR mice were kindly provided by the National Institute of Food and Drug Safety Evaluation (NIFDS). The other two groups of ICR mice were purchased from different vendors located in the United States (A:ICR) and Japan (B:ICR). All ICR mice that received MLDS exhibited overt diabetic symptoms throughout the study, and the incidence and development of diabetes mellitus were similar among the three ICR groups. The diabetic mice exhibited hyperglycemia, loss of body weight gain, decreased plasma insulin levels, impaired glucose tolerance, decreased number of insulin-positive cells, and decreased size of β-cells in the pancreas. The diabetes symptoms increased as the blood glucose level increased in the three ICR groups. In particular, the level of blood glucose in the STZ-treated group was higher in Korl:ICR and A:ICR mice than in B:ICR mice. The plasma insulin levels, glucose tolerance, blood chemistry, and morphological appearance of the pancreas were very similar in the ICR groups obtained from the three different sources. In conclusion, our results suggest that Korl:ICR, A:ICR, and B:ICR mice from different sources had similar overall responses to multiple low-dose STZ to induce diabetes mellitus.

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Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats

Cited by 29 publications

References 62 publications

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

Anti-inflammatory action of seed extract and polymeric nanoparticles of Syzygium cumini in diabetic rats infected with Candida albicans

Comparison of the response using ICR mice derived from three different sources to multiple low-dose streptozotocin-induced diabetes mellitus

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