Anti-inflammatory action of seed extract and polymeric nanoparticles of Syzygium cumini in diabetic rats infected with Candida albicans

Bitencourt, Paula Eliete Rodrigues; Cargnelutti, Lariane Oliveira; Stein, Carolina dos Santos; Lautenchleger, Raquel; Ferreira, Luana Mota; Sangoi, Manuela B.; Boligon, Alexandra Augusti; Duarte, Marta Mmf; Moresco, Rafael Noal; Cruz, Letícia; Zanette, Régis A.; Alves, Sydney Hartz; Moretto, Maria Beatriz

doi:10.7324/japs.2017.70102

Cited by 4 publications

(3 citation statements)

References 36 publications

(23 reference statements)

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“…In a recent study, the water extract of S. cumini seeds alleviated inflammation by causing the suppression of ectonucleotidase, acetylcholinesterase, adenosine deaminase, and dipeptidyl peptidase IV, and inhibited NO activities [74]. Similarly, methanol seed extract of S. cumini displayed greater anti-inflammatory potential compared to fruit juice in hemagglutination inhibition and membrane stabilization assays; this is attributed to the high polyphenolic content present in the methanolic fraction [75].…”

Section: Anti-inflammatory Potentialmentioning

confidence: 99%

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Qamar

Akhtar

Ismail

et al. 2022

Foods

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Syzygium cumini, locally known as Jamun in Asia, is a fruit-bearing crop belonging to the Myrtaceae family. This study aims to summarize the most recent literature related to botany, traditional applications, phytochemical ingredients, pharmacological activities, nutrition, and potential food applications of S. cumini. Traditionally, S. cumini has been utilized to combat diabetes and dysentery, and it is given to females with a history of abortions. Anatomical parts of S. cumini exhibit therapeutic potentials including antioxidant, anti-inflammatory, analgesic, antipyretic, antimalarial, anticancer, and antidiabetic activities attributed to the presence of various primary and secondary metabolites such as carbohydrates, proteins, amino acids, alkaloids, flavonoids (i.e., quercetin, myricetin, kaempferol), phenolic acids (gallic acid, caffeic acid, ellagic acid) and anthocyanins (delphinidin-3,5-O-diglucoside, petunidin-3,5-O-diglucoside, malvidin-3,5-O-diglucoside). Different fruit parts of S. cumini have been employed to enhance the nutritional and overall quality of jams, jellies, wines, and fermented products. Today, S. cumini is also used in edible films. So, we believe that S. cumini’s anatomical parts, extracts, and isolated compounds can be used in the food industry with applications in food packaging and as food additives. Future research should focus on the isolation and purification of compounds from S. cumini to treat various disorders. More importantly, clinical trials are required to develop low-cost medications with a low therapeutic index.

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Section: Anti-inflammatory Potentialmentioning

confidence: 99%

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Qamar

Akhtar

Ismail

et al. 2022

Foods

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show abstract

“…S. cumini is from the Myrtaceae family and is an evergreen tropical tree with possesses hypoglycemic, antiinflammatory, and antioxidant properties (Bitencourt et al 2017;Bitencourt et al 2016). All parts of the S. cumini have been widely applied for different medicinal purposes such as antidiabetic, astringent, carminative, stomachic, anti-scorbutic, and diuretic (Mittal et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…From literature, polyphenols and flavonoids are present in high levels in S. cumini. These phyto-molecules are expected to act as reducing agents and cap the formed nanoparticles (Bajpai et al 2005;Bitencourt et al 2017;Prasad and Swamy 2013).…”

Section: Introductionmentioning

confidence: 99%

Rapid and efficient colorimetric sensing of clindamycin and Fe3+ using controllable phyto-synthesized silver/silver chloride nanoparticles by Syzygium cumini fruit extract

et al. 2022

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The first evidence of a green, single-step, and additive-free process for the fabrication of silver/silver chloride nanoparticles (Ag/AgCl NPs) by fruit extract of Syzygium cumini (S. cumini) without the usage of any stabilizer and halide source was provided. The formation of nanoparticles was optimized to control the shape, size, and stability via various pHs of the reaction mixture, the quantity of fruit extract, temperature, concentrations of silver ion, and reaction time. The optimal conditions were determined: pH = 7.0, the quantity of the leaf extract = 3.0 mL, silver ion concentration = 1.0 mM, temperature = 60 °C, and incubation time = 40 min. As an application in colorimetric sensing, the ability of the prepared Ag/AgCl NPs to sense clindamycin and Fe3+ ion in an aqueous medium was investigated. The SPR band and color of the solution of Ag/AgCl NPs undergo dramatic changes in exposure to clindamycin with new SPR peaks appearing at 500 nm, accompanied by a color change from yellow to pink due to the aggregation of NPs. Under the optimized pH of 3.0, this sensor was shown a linear dynamic range from 10.0 to 100.0 µM with a LOD of 1.2 µM and good linear relationships (R2 = 0.99) for clindamycin. On the other hand, the quenching of the SPR peak at 412 nm was used to monitor the Fe3+ ions with wide linear ranges of 10.0–350.0 µM under the optimized pH (pH = 9) with a LOD of 5.6 µM. In addition, the proposed sensor displayed applicability in the real sample containing clindamycin (in capsules and injection ampoules) and Fe3+ ions (in water samples) detection. Graphical Abstract

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Nanoparticle formulation of Syzygium cumini, antioxidants, and diabetes

Bitencourt

2020

Diabetes

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Anti-inflammatory action of seed extract and polymeric nanoparticles of Syzygium cumini in diabetic rats infected with Candida albicans

Cited by 4 publications

References 36 publications

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Rapid and efficient colorimetric sensing of clindamycin and Fe3+ using controllable phyto-synthesized silver/silver chloride nanoparticles by Syzygium cumini fruit extract

Nanoparticle formulation of Syzygium cumini, antioxidants, and diabetes

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