Effects of N-Acetylcysteine on Auditory Brainstem Response Threshold Shift in Rabbits Exposed to Noise and Carbon Monoxide

Mortazavi, Seyedbagher; Kashani, Masoud Motalebi; Khavanin, Ali; Alameh, Abdolamir; Mirzaee, R; Akbari, Mehdi

doi:10.3844/ajassp.2010.201.207

Cited by 9 publications

(12 citation statements)

References 23 publications

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“…Although noise could cause more temporary hearing changes at higher frequencies, NAC and CoQ 10 was more effective on temporary hearing changes at lower frequencies. These findings are consistent with previous research results indicating more effects of antioxidant agents at the frequencies away from the frequencies with greater hearing changes (5). The greatest improvement occurred with NAC rather than CoQ 10 as demonstrated by functional data.…”

Section: Discussionsupporting

confidence: 92%

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Protective Effects of Coadministration of NAC and CoQ10 Against Noise Induced Hearing Loss

Habybabady

Mortazavi

Khavanin

et al. 2016

Iran Red Crescent Med J

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Background: Previous studies demonstrated partial attenuation of noise induced hearing loss (NIHL) by N-acetyl-L-cysteine (NAC) or CoQ10 (ubiquinone). Objectives: The present study investigates the protection effect of coadministration of NAC and CoQ10 against NIHL. Methods: In an experimental study in Iran in 2015, a total of 36 male Wistar rats (275 ± 25 g) were divided randomly based on the permuted block design into 6 experimental groups: (I) noise controls, (II) noise and NAC, (III) noise and CoQ10, (IV) noise and CoQ10 and NAC, (V) noise and saline (as vehicle of NAC) and (VI) noise and olive oil (as vehicle of CoQ10). Antioxidants and vehicles were intraperitoneally injected once a day for two days prior to and 1 hour before 102 ± 0.5 dB white noise exposure 8 h/day in 10 executive days and two days after the noise exposure daily. Distortion product otoacoustic emissions were measured one day before and 1, 7 and 21 days after the exposure. Results: The temporary hearing changes that occurred 1-day post exposure were not significantly different in all groups (P > 0.05). The total recovery (between 1-21 days after noise exposure) varied by a frequency increase between 1.08-19.10 in the noise group compared to 1.75-24.5 and 0.62-22.08 in animals treated with NAC and the combination of NAC and CoQ10 respectively. The less permanent hearing impairment was observed in noise exposed animals treated with either NAC or both NAC and CoQ10. Conclusions: The effect of coadministration of NAC and CoQ10 was neither additive nor synergic in protecting against NIHL.

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Section: Discussionsupporting

confidence: 92%

“…The effect of NAC on acoustic trauma has not been consistent in the literature. Administration of NAC before or within 24 hours of noise exposure has provided partial protection from NIHL in most animal studies (4)(5)(6)(7)(8). In contrast, some studies revealed no protective effect of NAC on NIHL (9, 10).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Coadministration of NAC and CoQ10 Against Noise Induced Hearing Loss

Habybabady

Mortazavi

Khavanin

et al. 2016

Iran Red Crescent Med J

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“…As executive functions are mainly managed by the frontal lobe of the brain, these findings support the hypothesis that states "smokers may have defects in their cognitive-executive functions" (Elwood et al, 1999). In this regard, the studies conducted on executive functions and cognitive performances of substance abusers, especially cigarette smokers, showed that nicotine-containing products such as cigarettes can disrupt executive tasks at workplace, where absolute concentration is required (Kalmijn, Van Boxtel, Verschuren, Jolles, & Launer, 2002;Mortazavi et al, 2010).…”

Section: Introductionsupporting

confidence: 67%

“…Brain function and mental performance are affected by psychomotor speed and mental flexibility following damage or injury in the cerebral cortex capillaries; therefore, cigarette smoking can cause some changes in the vascular mechanism for blood flow and some physiological changes in the organs like brain (Mortazavi et al, 2010;Newhouse, Potter, & Singh, 2004). Thus, the smoking mechanism in patients with stroke and dementia has been well-defined through the effect of smoking on the vascular system (Cees De Groot et al, 2000;Raininko & Tilvis, 1993;Rogers, Meyer, Judd, & Mortel, 1985;Terborg, Bramer, Weiller, & Röther, 2002).…”

Section: Discussionmentioning

confidence: 99%

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Alimohammadi

Kanrash

Abolaghasemi

et al. 2019

Basic Clin. Neurosci. J.

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Introduction:Noise is an environmental stressor and can cause or exacerbate mental disorders, and affect the individual performance in certain conditions. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance of the workers in the automotive industry. Methods:This research is a descriptive-analytical study with a cross-sectional design conducted on 300 workers randomly assigned into two groups of noise-exposed and nonexposed. They were examined using computerized tests, including the Tower of London test (TOL), Continuous Performance test (CPT), and Stroop test. The sound pressure levels were measured based on an 8-hour equal-loudness contour in each group according to ISO 9612 standard, using the Testo CEL-815 sound level meter. Results:The study of combined effects of noise and smoking on 12 CPT indicators using the 2-way Analysis of Variance (ANOVA) indicate that noise and smoking factors had a significant impact on the mean number of errors and correct responses in the third 50-stimuli stage, the mean number of errors and correct responses in the second 50-stimuli stage with P<0.001, P<0.001, P=0.012 and P<0.001 for smoking respectively, but only noise affected the other 7 indicators (P<0.001). Conclusion:Smoking and noise have negative impacts on concentration, attention, and cognitive processing speed, which can lead to an individual's mistakes and delayed decision making at the workplace. Highlights• Brain function, cognitive processing speed, and individual performance are significantly lower in smokers compared to non-smokers.• Noise and smoking have significant effects on cognitive performance indicators.• High noise exposure is associated with the risk of an increased number of errors in responding to the test stimuli.• Addiction to cigarettes and other nicotine-containing products harms cognitive performance, including executive functions. Plain Language SummaryExcessive noise in industrial environments can cause hearing impairment, speech problems, sleep disorders, noise annoyance, and decreased efficiency of the workers. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance and psychological flexibility of workers in the automotive industry in Iran. The workers were assessed by proper tools to examine their mental performance and responses to low-or high-frequency noises. We found that long-time exposure to noise significantly affects the individual's performance and psychomotor speed, which resulted in impaired concentration, poor working performance, and increased mistakes at work. This study revealed the relationship between smoking and brain functions in terms of response type and decision-making.

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“…Previous studies have established the significant role of antioxidants (e.g., N-acetylcysteine and α-Tocopherol) in the prevention and treatment of NIHL caused by the combined exposure to noise and CO (12)(13)(14). Hydrogen gas (H 2 ) has shown to have healing effects in the treatment of several disorders (15).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to Noise and Carbon Monoxide in Guinea Pigs

et al. 2018

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Background: People might simultaneously be exposed to noise and carbon monoxide in occupational settings. The previous studies revealed that the inhalation of molecular hydrogen (H2) exerts some healing effects on multiple diseases including hearing loss. Objectives: The levels of free radicals have been shown to increase due to the exposure to noise plus carbon monoxide. This study examined the possible protective effects of hydrogen inhalation following simultaneous exposure to noise and carbon monoxide in Guinea pigs. Methods: Twelve Guinea pigs were randomly divided into two different groups: (1) Exposed to noise plus carbon monoxide and (2) exposed to noise plus carbon monoxide along with the inhalation of hydrogen. Auditory brainstem responses (ABRs) at different frequencies of 2, 4, 8, and 16 kHz were measured before and immediately after the exposure. Results: The ABR thresholds measured immediately after the simultaneous exposure to noise and carbon monoxide significantly increased at all frequencies in group 1 while in group 2, the ABR thresholds measured immediately after the inhalation of hydrogen significantly reduced at 4, 8, and 16 kHz (P values < 0.05). Conclusions: This finding indicates that there is a protective effect associated with the inhalation of 2% hydrogen on the development of hearing loss after the simultaneous exposure to noise and carbon monoxide and this effect was fairly significant at higher frequencies.

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Effects of N-Acetylcysteine on Auditory Brainstem Response Threshold Shift in Rabbits Exposed to Noise and Carbon Monoxide

Cited by 9 publications

References 23 publications

Protective Effects of Coadministration of NAC and CoQ10 Against Noise Induced Hearing Loss

Protective Effects of Coadministration of NAC and CoQ10 Against Noise Induced Hearing Loss

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to Noise and Carbon Monoxide in Guinea Pigs

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