Effects of micronization on properties of Chaenomeles sinensis (Thouin) Koehne fruit powder

Zhang, Lihua; Xu, Huaide; Li, Shun-feng

doi:10.1016/j.ifset.2009.05.010

Cited by 72 publications

(43 citation statements)

References 13 publications

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“…In the present study, 10 µM Aβ (25-35) significantly increased the ROS level in cultured neurons, and this was inhibited by CSF. In addition, CSF contains flavonoids as one of the main phytochemical constituents, which are effective in preventing free radical-caused oxidative damage (Zhou et al, 2007;Zhang et al, 2009). Therefore, it is possible that the favorable effect of CSF on Aβ (25-35)-induced cognitive deficits can be attributed to the inhibition of ROS generation.…”

Section: +mentioning

confidence: 99%

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Jung¹,

Song²,

Seong³

2012

Korean Journal of Medicinal Crop Science

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Section: +mentioning

confidence: 99%

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Jung¹,

Song²,

Seong³

2012

Korean Journal of Medicinal Crop Science

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“…The percentage of growth inhibition was determined with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (12). Hepatocellular carcinoma H 22 cells (4,000 cells/well) were seeded into 96-well plates and treated with EEC.…”

Section: Methodsmentioning

confidence: 99%

Ethanol extract of Chaenomeles speciosa Nakai induces apoptosis in cancer cells and suppresses tumor growth in mice

et al. 2013

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Chaenomeles speciosa Nakai is commonly used in traditional Chinese medicine for a variety of health-promoting effects. The present study aimed to investigate the antitumor effects of Chaenomeles speciosa Nakai. The tumor-inhibitory activity of the ethanol extract of Chaenomeles speciosa Nakai (EEC) was evaluated by in vitro growth assays of tumor cells and in vivo H22 tumor formation assays in mice. Mitochondrial membrane potential and DNA ladder assays were used to detect tumor cell apoptosis in the presence of EEC. To investigate the cellular targets of EEC, the immunomodulatory genes PD-L1, Foxp3 and TGF-β were detected in the tumor tissue using reverse transcription polymerase chain reaction (RT-PCR). Immune responses were determined by hemolysis and lymphocyte proliferation assays. EEC markedly inhibited the proliferation of the H22 cells in a dose-dependent manner. Moreover, it induced DNA fragmentation and decreased the mitochondrial membrane potential. In vivo, EEC inhibited tumor growth and enhanced the immune responses in mice, while the expression of PD-L1, Foxp3 and TGF-β was inhibited in the tumor tissue. These results provide the first evidence that EEC may inhibit tumor growth by directly killing tumor cells and enhancing immune function. Thus, it is a natural source for safe anticancer medicine.

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“…As described in the study conducted on C. sinensis fruit, the author revealed that the nanotechnology process promotes the diminishing of the ferric reducing antioxidant power (FRAP), but at the same time, this technology was found to improve DPPH free radical inhibition activity (Zhang et al, 2009). Therefore they suggested that FRAP analysis may be adversely affected by particle size.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 98%

Exploring the Effect of Nanotechnology Process on Physical and Chemical Properties of Herbs: A Short Review.

Norhidayah¹,

Noriham²,

RusopM³

2017

IJAR

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Effects of micronization on properties of Chaenomeles sinensis (Thouin) Koehne fruit powder

Cited by 72 publications

References 13 publications

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

Ethanol extract of Chaenomeles speciosa Nakai induces apoptosis in cancer cells and suppresses tumor growth in mice

Exploring the Effect of Nanotechnology Process on Physical and Chemical Properties of Herbs: A Short Review.

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