Effects of MgO whiskers on mechanical properties and crystallization behavior of PLLA/MgO composites

Zhao, Yun; Liu, Bei; Chen, You; Chen, Minfang

doi:10.1016/j.matdes.2015.09.157

Cited by 52 publications

(39 citation statements)

References 43 publications

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“…Besides, its alkaline degradation products may be in favor of constructing weakly alkaline microenvironments for cellular responses; the magnesium ion is widely involved in human metabolisms, playing an significant role in regulating cellular responses [15] . In addition, it has been previously used as a rigid filler for reinforcing polymer [16,17] . Haldorai and Shim [18] prepared chitosan/MgO composites by chemical precipitation method and found the composites showed a much higher killing rate against Escherichia coli (E. coli) compared with chitosan.…”

Section: Introductionmentioning

confidence: 99%

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Shuai

Guo

Gao

et al. 2024

IJB

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Bone repair failure caused by implant-related infections is a common and troublesome problem. In this study, an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide (nMgO) to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The results indicated the scaffold exerted high antibacterial activity. The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species (ROS) and direct contact action, respectively, which resulted in the damage of their structures and functions. Besides, nMgO significantly increased the compressive properties of the scaffold including strength and modulus, due to its excellent mechanical properties and uniform dispersion in the PHBV matrix. Moreover, the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold. The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation, as well as osteogenic differentiation. The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering. Keywords: Nano magnesium oxide; antibacterial scaffolds; degradation properties; cytocompatibility; mechanical properties

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Section: Introductionmentioning

confidence: 99%

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Shuai

Guo

Gao

et al. 2024

IJB

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“…It has been reported that the dissolution of MgO in vitro prominently influences the solution pH through alkaline degradation [ 19 ]. Recently, the researchers utilized the different shapes of MgO [ 9 , 19 , 20 , 21 , 22 , 23 , 24 ] as fillers and introduced them to PLLA for preparing composites. The results mostly showed that the mechanical properties and thermal behavior of PLLA improved significantly with the presence of MgO fillers, which was also proved in our works [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…In this work, the MgO whiskers were modified using stearic acid, and the chemical bondings were obtained through the interaction between them, as demonstrated by our previous work [ 24 ]. Because stearic acid is effective in modifying inorganic fillers like hydroxyapatite [ 30 ] and TiO 2 [ 31 ] through changing the polarities, it was greatly helpful in improving the distribution of MgO whiskers and enhancing the interface of the PLLA composites.…”

Section: Introductionmentioning

confidence: 99%

The Degradation Properties of MgO Whiskers/PLLA Composite In Vitro

Zhao

Liu

Bi³

et al. 2018

IJMS

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In this study, composite films of stearic acid–modified magnesium oxide whiskers (Sa–w-MgO)/poly-l-lactic acid (PLLA) were prepared through solution casting, and the in vitro degradation properties and cytocompatibility of the composites with different whisker contents were investigated. The results showed that the degradation behavior of the composite samples depended significantly on the whisker content, and the degradation rate increased with the addition of MgO content. Furthermore, the degradation of the composites with higher contents of whiskers was influenced more severely by the hydrophilicity and pH value, leading to more final weight loss, but the decomposition rate decreased gradually. Furthermore, the pH value of the phosphate buffer solution (PBS) was obviously regulated by the dissolution of MgO whiskers through neutralization of the acidic product of PLLA degradation. The cytocompatibility of the composites also increased remarkably, as determined from the cell viability results, and was higher than that of PLLA at the chosen whisker content. This was beneficial for the cell affinity of the material, as it notably led to an enhanced biocompatibility of the PLLA, in favor of promoting cell proliferation, which significantly improved its bioactivity, as well.

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“…To get implants that stimulate bone formation, studies have shown that the use of nanoparticles of magnesium oxide with hydroxyapatite is a subject of great interest. 15 Also, there are several important considerations that need to be taken into consideration in the process of rebuilding a bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration

Ghiţulică

Cucuruz

Voicu

et al. 2019

Int J Applied Ceramic Tech

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In this study, chemical precipitation methods were used to obtain ceramic materials doped with magnesium ions in order to improve the regeneration properties of materials used for tissue engineering. Two different ratios of magnesium oxide were used to dope the ceramic powder, more precisely 5% and 10%. The synthesized materials were characterized to determine the calcination temperature of the precursor powder by means of thermal analysis; to determine the mineralogical composition, X-ray diffraction was employed and the scanning electron microscopy was used to determine the microstructure. To make use of these ceramics as biomaterials, viability and proliferation cell tests have been performed. Since synthetic materials have several limitations with regard to medical applications, the materials based on HAp substituted with Mg ions are a promising solution for the regeneration of bone defects because they have a similar bone structure. The presence of Mg in the material proves to be beneficial because this element plays an important role in bone cell regeneration, and more specifically, in stimulating osteoblast proliferation. The materials synthesized in this work present a suitable morphology for uses in bone regeneration because they offer to cells a friendly environment for growth and anchoring.

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Effects of MgO whiskers on mechanical properties and crystallization behavior of PLLA/MgO composites

Cited by 52 publications

References 43 publications

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

The Degradation Properties of MgO Whiskers/PLLA Composite In Vitro

Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration

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