Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration

Abstract

In this study, chemical precipitation methods were used to obtain ceramic materials doped with magnesium ions in order to improve the regeneration properties of materials used for tissue engineering. Two different ratios of magnesium oxide were used to dope the ceramic powder, more precisely 5% and 10%. The synthesized materials were characterized to determine the calcination temperature of the precursor powder by means of thermal analysis; to determine the mineralogical composition, X-ray diffraction was employed and the scanning electron microscopy was used to determine the microstructure. To make use of these ceramics as biomaterials, viability and proliferation cell tests have been performed. Since synthetic materials have several limitations with regard to medical applications, the materials based on HAp substituted with Mg ions are a promising solution for the regeneration of bone defects because they have a similar bone structure. The presence of Mg in the material proves to be beneficial because this element plays an important role in bone cell regeneration, and more specifically, in stimulating osteoblast proliferation. The materials synthesized in this work present a suitable morphology for uses in bone regeneration because they offer to cells a friendly environment for growth and anchoring.

Application of bioactive metal ions in the treatment of bone defects

“…The degradation of these ceramics in the body produces Ca 2+ and phosphate ions, which can promote new bone formation through bone induction. 157 Some metal ions, such as Sr 2+ and Zn 2+ , can inhibit osteoclast activity and enhance osteogenic activity. Therefore, these ions could be used to treat bone defects with osteoporosis.…”

“…The degradation of these ceramics in the body produces Ca 2+ and phosphate ions, which can promote new bone formation through bone induction. 157…”

Potential Load-Bearing Bone Substitution Material: Carbon-Fiber-Reinforced Magnesium-Doped Hydroxyapatite Composites with Excellent Mechanical Performance and Tailored Biological Properties

“…14 Mg 2+ plays a vital role in bones by maintaining healthy bone growth and providing a suitable environment for cell development. 15 To date, Most studies have concentrated on the effects of Mg doping on crystal morphology, structure, composition, phase, crystallinity, thermal stability, and sintering properties. However, the effect of the crystal structure from Mg doping and the subsequent sintering process on the degradation and bioactivity of Mg-HA bioceramic Mg-doped HAs (Mg-HAs) is rarely reported.…”

“…In addition, Mg 2+ is related to the adhesion and growth of osteoblasts . Mg 2+ plays a vital role in bones by maintaining healthy bone growth and providing a suitable environment for cell development . To date, Most studies have concentrated on the effects of Mg doping on crystal morphology, structure, composition, phase, crystallinity, thermal stability, and sintering properties.…”

Enhancing the mechanical properties and cytocompatibility of magnesium potassium phosphate cement by incorporating oxygen-carboxymethyl chitosan

“…This reaction is a chemical dissolution reaction, where the entanglement of the crystals in the paste leads the self-setting of bone cement [ 12−14 ]. Moreover, recent studies have found that the proper release of magnesium ions during MPC degradation can enhance the bioactivity of osteoblasts [ 15 ]. Unfortunately, the ammonia emission during struvite preparation could restrict its clinical application range.…”