Effects of mercury and selenite on δ-aminolevulinate dehydratase activity and on selected oxidative stress parameters in rats

Perottoni, Juliano; Lobato, Luciana Pereira; Silveira, A. L. R. Damaso da; Rocha, João Batista Teixeira da; Emanuelli, Tatiana

doi:10.1016/j.envres.2003.08.007

Cited by 46 publications

(16 citation statements)

References 43 publications

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“…Many studies have reported that, when selenium in the form of sodium selenite is given in combination with mercury administration, it significantly alleviates the mercury-induced toxic effects (Kalender et al 2013;Agha et al 2014). Selenium possesses an affinity for mercury higher than that of sulfhydryl compounds and the protection offered by sodium selenite in mercury intoxication has been based on to the formation of Hg-Se-S complex to form a non-toxic complex (Perottoni et al 2004). In the present study, treatment of vitamin E and / or sodium selenite to the mercuric chloride-treated rats enhanced SOD, CAT, GPx and GST activities and reduced malondialdehyde level in the lung tissue.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Çelikoğlu

Aslantürk

Kalender

2015

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 99%

“…Mercury exposure encourages formation of reactive oxygen species (ROS) (Perottoni et al 2004). Excessive production of ROS due to mercuric chloride treatment causes oxidative stress (Haibo et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Çelikoğlu

Aslantürk

Kalender

2015

Braz. arch. biol. technol.

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“…Moreover, d-aminolevulinic acid dehydratase activity (ALAD) has been used as a biomarker of Pb contamination or oxidative stress in haematological systems. Despite that, few studies report ALAD activity in fish (Martin and Black 1998;Perottoni et al 2004;Alves Costa et al 2007). Santos Bay is located in Brazil on the central coast of southeastern São Paulo State (24°00 0 S; 46°21 0 W).…”

Section: Introductionmentioning

confidence: 94%

Biomarkers of exposure to metal contamination and lipid peroxidation in the benthic fish Cathorops spixii from two estuaries in South America, Brazil

et al. 2009

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Biomarkers as lipid peroxidation, metallothionein and delta-aminolevulinic acid dehydratase were determined in Cathorops spixii to compare the biological responses of this fish from estuaries with distinct anthropogenic influence. Three areas were selected in two estuaries in accordance with the levels of contamination for the polluted (Santos/São Vicente) and with the hydrodynamic characteristics for the non-polluted (Cananéia) estuary. Water characteristics and mercury levels in C. spixii confirmed a high human influence in the polluted system. In general, the biomarkers showed differences between the estuaries, suggesting disturbances in the specific cell mechanisms due to the presence of multiple xenobiotics in the contaminated system. Therefore, these biomarkers are recommended to promote more accurate information about the exposure to pollutants. Additionally, the study of the effect of the multiple xenobiotics on resident species such as the benthic fish C. spixii can favor a better assessment of the environmental quality of these systems.

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“…Perottoni et al (2004b) reported that organic Se in vitro prevented I-Hg-induced lipid peroxidation, while in acute in vivo experiment there was no such effect. Inorganic Se was reported to diminish I-Hg-induced lipid peroxidation in serum of subchronically (Agha et al 2014) and in kidneys of acutely exposed rats, but failed to exert the same effects in vitro (Perottoni et al 2004a), in acutely exposed mice (Farina et al 2003), or in subchronically exposed rats (Agarwal and Behari 2007). In the acute study performed by Agarwal et al (2010), pretreatment and posttreatment with inorganic Se restored lipid peroxidation in the kidneys and brain of adult rats exposed to I-Hg.…”

Section: Nmol Tbars/g Wet Tissue Weightmentioning

confidence: 94%

Metallothionein, essential elements and lipid peroxidation in mercury-exposed suckling rats pretreated with selenium

et al. 2015

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Detoxification of mercury (Hg) with selenium (Se) in the early postnatal period with regard to the expression of metallothionein protein (MT), essential element status, and lipid peroxidation level in tissues has not been studied. Seven-day-old Wistar pups were orally pretreated with Se [6 μmol Na2SeO3/kg body weight (b.w.)] for 3 days and then cotreated with Hg (6 μmol HgCl2/kg b.w.) for the following 4 days. This group (Se + Hg) was compared to the groups treated with Hg, Se, or vehicle (control). Compared to the Hg-group, Se + Hg-group exhibited lower renal MT expression, reduced accumulation of Hg, Cu and Zn, and reduced excretion of Se, Hg and Zn in urine. In the liver, MT was stimulated by Se treatment in both, Se and Se + Hg-group. Hepatic and brain levels of the endogenous essential elements Cu, Fe, Mg, and Zn remained unchanged in all of the studied groups. Brain Hg levels and oxidation of lipids measured as thiobarbituric acid reactive substances were diminished in Se + Hg-group of pups compared to the Hg-group. This study suggests that Se pretreatment can help reduce Hg in the tissues of suckling rats, simultaneously preventing impairment of essential element levels in the kidneys and their excessive excretion via urine. Also, Se was shown to prevent oxidative damage of lipids in the brain, which is particularly susceptible to Hg during the early postnatal period.

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Effects of mercury and selenite on δ-aminolevulinate dehydratase activity and on selected oxidative stress parameters in rats

Cited by 46 publications

References 43 publications

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Biomarkers of exposure to metal contamination and lipid peroxidation in the benthic fish Cathorops spixii from two estuaries in South America, Brazil

Metallothionein, essential elements and lipid peroxidation in mercury-exposed suckling rats pretreated with selenium

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